Opioid receptor subtype-selective agents
View Patent ↗Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.
1. A compound of Formula I:
wherein
X 1 is a bond or a saturated or unsaturated alkylene group;
X 2 and X 3 are bonds;
R 6 is CH 2 N(CH 3 ) 2 ; and
R 7 and R 8 are independently selected from the group consisting of m-tert-butyl phenyl, p-tert-butyl phenyl, 3,4-dimethyl phenyl, phenol, and methoxy phenyl; or a pharmaceutically acceptable salt of said compound.
2. The compound of claim 1 , wherein the compound comprises 0 to 2 chiral centers.
3. The compound of claim 1 , wherein the compound is achiral.
4. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 1 and a pharmaceutically acceptable carrier.
5. The composition of claim 4 further comprising a μ-agonist.
6. The composition of claim 5 , wherein the μ-agonist comprises morphine or fentanyl.
7. A method for diagnosing or treating a condition mediated by an opioid receptor, said method comprising administering an effective amount of the compound of claim 1 to a patient in need thereof.
8. The method of claim 7 , wherein said condition is selected from the group consisting of pain, inflammation, and depression.