Cyclosporin compositions
View Patent ↗Cyclosporin A compositions are disclosed herein comprising an oil and a surfactant. These are useful in the treatment of dry eye disease.
1. A method of treating dry eye disease comprising administering to an eye of a mammal in need of such treatment an ophthalmically acceptable emulsion comprising from about 0.001% to about 0.1% cyclosporin A, a combination of castor oil and olive oil, a surfactant, and carboxymethylcellulose, wherein the surfactant is selected from the group consisting of Polysorbate 80, Polysorbate 60, Polysorbate 40, Polysorbate 20, a stearate surfactant, glyceryl stearate, isopropyl stearate, polyoxyl stearate, propylene glycol stearate, sucrose stearate, polyethylene glycol, polyethylene oxide, polypropylene oxide, a polyethylene oxide-polypropylene oxide copolymer, an alcohol ethoxylate, an alkylphenol ethoxylate, an alkyl glycoside, an alkyl polyglycoside, a fatty alcohol, a cellulose derivative, hydroxypropylmethyl cellulose, carboxymethyl cellulose, a polyacrylic acid, a Carbomer, a phosphalipid, phosphatidyl chloline, and a phosphatidyl serine.
2. The method of claim 1 , wherein the ophthalmically acceptable emulsion further comprises cassia oil.
3. The method of claim 1 , wherein the ophthalmically acceptable emulsion further comprises Polyoxyethylene (20) Stearyl Ether.