IP Library Granted Patent US 7,803,310
Granted Patent B2
US 7,803,310 · App. 11/917,603 · Granted Sep 28, 2010

Crosslinked polyethylene article

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Quick Facts
Patent No.
US 7,803,310
App. No.
11/917,603
Granted
Sep 28, 2010
Kind
B2
Abstract

A method of manufacturing an article may include crosslinking a UHMWPE preform, shaping the crosslinked preform, heat-treating the shape in a temperature-controlled oven and low-oxygen environment, and inspecting the heat-treated shape for conformance to article specifications.

Claims (43)

1. A method of manufacturing an article formed at least in part by ultra-high molecular weight polyethylene (UHMWPE), comprising:

irradiating a UHMWPE preform; then

machining the article from the preform such that material in excess of a final geometry of the article remains; then

heat-treating the machined irradiated preform in a low-oxygen or oxygen-free environment, at a temperature below the UHMWPE melt temperature, to form an irradiated, machined, and stabilized article;

further machining the article to remove the excess material; and then

inspecting the irradiated, machined, and stabilized article for conformance to article specifications.

2. The method of claim 1 , wherein irradiating comprises delivering a radiation dose in the range of about 5 Mrad to about 10 Mrad.

3. The method of claim 2 , wherein the radiation dose is about 8 Mrad.

4. The method of claim 1 , further comprising maintaining the preform in a low-oxygen or oxygen-free environment during irradiation.

5. The method of claim 1 , further comprising storing the irradiated preform prior to machining.

6. The method of claim 5 , further comprising maintaining the preform in a low-oxygen or oxygen-free environment during storage.

7. The method of claim 6 , further comprising maintaining the preform in a low-oxygen or oxygen-free environment during irradiation.

8. The method of claim 1 , further comprising minimizing the amount of time during which the irradiated preform is exposed to air.

9. The method of claim 1 , further comprising maintaining the preform or article in a non-oxidizing environment.

10. The method of claim 9 , wherein the preform or article is maintained in a non-oxidizing environment during at least one of irradiating, machining, heat-treating, and inspecting.

11. The method of claim 9 , wherein the preform or article is maintained in a non-oxidizing environment for at least some of the time period between two consecutive steps.

12. The method of claim 11 , wherein the preform or article is maintained in a non-oxidizing environment during at least one of irradiating, machining, heat-treating, and inspecting.

13. The method of claim 1 , further comprising completing all steps following irradiation of the preform and just before commencement of heat treatment such that the total exposure time to room air or equivalent is no more than 24 hours.

14. The method of claim 1 , further comprising packaging the inspected article.

15. The method of claim 14 , further comprising completing all steps following irradiation of the preform and just before commencement of heat treatment such that the total exposure time to room air or equivalent is no more than 24 hours.

16. The method of claim 1 , wherein heat-treating has a duration of about 18 hours to about 36 hours.

17. The method of claim 1 , wherein the heat-treating has a duration of about 24 hours at an average temperature in the range of about 85 to about 90 degrees Celsius.

18. The method of claim 1 , wherein heat-treating is performed in a vacuum oven or a nitrogen oven.

19. A method of manufacturing an article formed at least in part by ultra-high molecular weight polyethylene (UHMWPE), comprising in the following order:

irradiating a UHMWPE preform; then

machining the article from the preform such that material in excess of a final geometry of the article remains; then

heat-treating the article in a low-oxygen or oxygen-free environment at an average temperature in the range of about 80 to about 100 degrees Celsius; then

further machining the article to remove the excess material; and then

inspecting the article for conformance to a specification.

20. The method of claim 19 , further comprising packaging the article after inspection.

21. The method of claim 19 , further comprising storing the preform in a low-oxygen environment at least during the period after irradiating and before machining the article from the preform.

22. The method of claim 19 , wherein the excess material comprises a layer of about 0.02 inches on at least one surface of the article.

23. The method of claim 19 , wherein heat-treating is performed for up to about 24 hours at a temperature in the range of about 85 to about 90 degrees Celsius.

24. The method of claim 19 , wherein the preform is irradiated with about 8 Mrad of gamma radiation.

25. A method of manufacturing an article formed at least in part by ultra-high molecular weight polyethylene (UHMWPE), comprising in the following order:

irradiating a UHMWPE preform with about 8 Mrad of gamma radiation; then

machining the article from the preform such that about 0.02 inches of material in excess of a final geometry of the article remains on at least one surface of the article; then

heat-treating the article in a low-oxygen or oxygen-free environment for up to about 24 hours at a temperature in the range of about 85 to about 90 degrees Celsius; then

further machining the article to remove the excess material; then

inspecting the article for conformance to a specification; then

packaging the article; and then

sterilizing the article.

26. The method of claim 20 , further comprising sterilizing the article after packaging.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2019
From: DEERFIELD MANAGEMENT COMPANY, L.P., AS COLLATERAL AGENT
To: OMNI LIFE SCIENCE, INC.
Reel/Frame 048908/0510 →
RELEASE OF SECURITY INTEREST Recorded Mar 1, 2019
From: PARTNERS FOR GROWTH III, L.P.
To: OMNI LIFE SCIENCE, INC.
Reel/Frame 048482/0702 →
RELEASE OF SECURITY INTEREST Recorded Feb 25, 2019
From: SILICON VALLEY BANK
To: OMNI LIFE SCIENCE, INC.
Reel/Frame 048427/0210 →
SECURITY INTEREST Recorded Jun 5, 2018
From: OMNI LIFE SCIENCE, INC.
To: DEERFIELD MANAGEMENT COMPANY, L.P.
Reel/Frame 045990/0674 →
SECURITY INTEREST Recorded Apr 16, 2014
From: OMNI LIFE SCIENCE, INC.
To: DEERFIELD PRIVATE DESIGN FUND II, L.P.; DEERFIELD PRIVATE DESIGN INTERNATIONAL II, L.P.
Reel/Frame 032684/0599 →
ADDENDUM TO IP SECURITY AGREEMENT Recorded Oct 18, 2011
From: OMNI LIFE SCIENCE, INC.
To: SILICON VALLEY BANK
Reel/Frame 027076/0980 →
SECURITY AGREEMENT Recorded Oct 17, 2011
From: OMNI LFE SCIENCE, INC.
To: PARTNERS FOR GROWTH III, L.P.
Reel/Frame 027074/0770 →
SECURITY AGREEMENT Recorded Aug 30, 2010
From: OMNI LIFE SCIENCE, INC.
To: SILICON VALLEY BANK
Reel/Frame 024906/0797 →
SECURITY AGREEMENT Recorded Aug 20, 2010
From: OMNI LIFE SCIENCE, INC.
To: PARTNERS FOR GROWTH III, L.P.
Reel/Frame 024864/0254 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2007
From: CHEAL, EDWARD J.
To: OMNI LIFE SCIENCE, INC.
Reel/Frame 020249/0405 →