Milk fat globule epidermal growth factor—factor VIII and sepsis
View Patent ↗Provided are methods of treating a mammal undergoing sepsis or at risk for sepsis. Also provided are methods of preventing or treating a physiologic effect of sepsis in a mammal. Additionally provided is the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the treatment of a mammal having sepsis or at risk for sepsis.
1. A method of reducing thymocyte apoptosis in sepsis in a human, the method comprising administering to the human at least 20 μg/kg body weight (BW) an amount of a milk fat globule epidermal growth factor-factor VIII (MFG-E8), wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:1, and wherein the MFG-E8 is administered by intravenous administration.
2. The method of claim 1 , wherein the human is administered MFG-E8-rich exosomes derived from mammalian cells.
3. The method of claim 1 , wherein the MFG-E8 is recombinant MFG-E8.
4. The method of claim 1 , wherein the MFG-E8 has an amino acid sequence as set forth in SEQ ID NO:1.
5. The method of claim 1 , wherein the sepsis is surgical sepsis.