Inhibitors of checkpoint kinases

1 . A compound of the Formula A:

wherein:

a is 0 or 1; b is 0 or 1; m is 0, 1, or 2; n is 0, 1, 2, 3, 4 or 5; p is 0, 1, 2, 3, 4 or 5;

Ring A is selected from: (C 3 -C 8 )cycloalkyl, aryl and heterocyclyl;

R 1 is selected from: H, (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, (C═O) a O b C 2 -C 10 alkenyl, (C═O) a O b C 2 -C 10 alkynyl, CO 2 H, halo, OH, O b C 1 -C 6 perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b C 3 -C 8 cycloalkyl, S(O) m NR 7 R 8 , S(O) m —(C 1 -C 10 )alkyl, SH and (C═O) a O b heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 2 is selected from: H, (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, (C═O) a O b C 2 -C 10 alkenyl, (C═O) a O b C 2 -C 10 alkynyl, CO 2 H, Br, I, OH, O b C 1 -C 6 perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b C 3 -C 8 cycloalkyl, S(O) m NR 7 R 8 , S(O) m —(C 1 -C 10 )alkyl, SH and (C═O) a O b heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 6 is: (C═O) a O b C 1 -C 10 alkyl, (C═O) a O b aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b C 1 -C 6 perfluoroalkyl, O a (C═O) b NR 7 R 8 , oxo, CHO, (N═O)R 7 R 8 , S(O) m NR 7 R 8 , S(O) m —(C 1 -C 10 )alkyl, SH or (C═O) a O b C 3 -C 8 cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6a ;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C 6 )alkylene-aryl, (C═O)heterocyclyl, (C═O)—N(R b ) 2 , (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(R b ) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 -C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 -C 6 alkyl, oxo, and N(R b ) 2 ;

R 7 and R 8 are independently selected from: H, (C═O)O b C 1 -C 10 alkyl, (C═O)O b C 3 -C 8 cycloalkyl, (C═O)O b aryl, (C═O)O b heterocyclyl, C 1 -C 10 alkyl, aryl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, heterocyclyl, C 3 -C 8 cycloalkyl, S(O) m R a , and (C═O)NR b 2 , said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 6a , or R 7 and R 8 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R 6a ;

R a is H, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is independently H, (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, (C═O)OC 1 -C 6 alkyl, (C═O)C 1 -C 6 alkyl or S(O) m R a ;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

2 . The compound according to claim 1 of the Formula B:

wherein:

X is Nor CH; and

all other substituents are as defined in claim 1 ;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

3 . A compound which is selected from:

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

4-[4-(2-morpholin-4-yl-2-oxoethyl)piperazin-1-yl]-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

(4-{2-[(5-pyridin-3-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl}morpholin-2-yl)methanol;

2-({2-[(5-pyrimidin-5-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl}amino)ethanol;

N 4 -propyl-N 2 -(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridine-2,4-diamine;

4-[4-(methylsulfonyl)piperazin-1-yl]-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

N5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-amine;

4-(4-acetylpiperazin-1-yl)-N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]pyridin-2-amine;

N[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

N,N-dimethyl-4-{2-[(5-pyrimidin-5-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl}piperazine-1-sulfonamide;

4-piperazin-1-yl-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

4-(4-acetylpiperazin-1-yl)-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

4-morpholin-4-yl-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

(4-{2-[(5-pyrimidin-5-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl}morpholin-2-yl)methanol;

N 4 -(4-aminobutyl)-N 2 -(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridine-2,4-diamine;

N-[5-(2-methylpyrimidin-5-yl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

N-[5-(2-methylpyrimidin-5-yl)-1,3-thiazol-2-yl]-4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-amine;

N-[5-(2-methylpyrimidin-5-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-6-piperazin-1-ylpyridin-2-amine;

6-[4-(aminomethyl)cyclohexyl]-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

6-(4-acetylpiperazin-1-yl)-N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]pyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-6-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-6-morpholin-4-ylpyridin-2-amine;

N-(3-aminopropyl)-N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]pyridine-2,6-diamine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-N-(2-pyrrolidin-1-ylethyl)pyridine-2,6-diamine;

6-piperazin-1-yl-N-(5-pyrimidin-5-yl-1,3-thiazol-2-yl)pyridin-2-amine;

N-[5-(2-methylpyrimidin-5-yl)-1,3-thiazol-2-yl]-6-piperazin-1-ylpyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-4-(morpholin-4-ylmethyl)pyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-5-(morpholin-4-ylmethyl)pyridin-2-amine;

N-[5-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-amine;

N-{5-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-morpholin-4-ylpyridin-2-amine;

N-[5-(5-bromopyridin-3-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

4-(2-{[5-(5-bromopyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)-N,N-dimethylpiperazine-1-carboxamide;

4-morpholin-4-yl-N-{5-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

N-{5-[5-(3,5-dimethylisoxazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-morpholin-4-ylpyridin-2-amine;

N-[5-(3,3′-bipyridin-5-yl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

4-morpholin-4-yl-N-[5-(5-pyrimidin-5-ylpyridin-3-yl)-1,3-thiazol-2-yl]pyridin-2-amine;

N-[5-(2′-methoxy-3,3′-bipyridin-5-yl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

N-[5-(6′-methoxy-3,3′-bipyridin-5-yl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

N-{5-[5-(2-methoxypyrimidin-5-yl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-morpholin-4-ylpyridin-2-amine;

4-piperazin-1-yl-N-{5-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

N-{5-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-piperazin-1-ylpyridin-2-amine;

N-[5-(3,3′-bipyridin-5-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

N-[5-(5-isothiazol-4-ylpyridin-3-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

N-[5-(6′-fluoro-3,3′-bipyridin-5-yl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

N-methyl-5′-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-3,3′-bipyridin-6-amine;

N-ethyl-5′-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-3,3′-bipyridin-6-amine;

N-{5-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-piperidin-1-ylpyridin-2-amine;

N-[2-(3-aminopropoxy)-5-chlorophenyl]-5-pyrimidin-5-yl-1,3-thiazol-2-amine;

N-[2-(3-aminopropoxy)-5-chlorophenyl]-5-(5-bromopyridin-3-yl)-1,3-thiazol-2-amine;

N-[5-(3-bromophenyl)-1,3-thiazol-2-yl]-4-morpholin-4-ylpyridin-2-amine;

N-[5-(3-bromophenyl)-1,3-thiazol-2-yl]-4-piperazin-1-ylpyridin-2-amine;

5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinonitrile;

5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinic acid;

N-(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)ethane-1,2-diamine;

N-(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)propane-1,3-diamine;

2-[(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)amino]ethanol;

4-morpholin-4-yl-N-{5-[5-(1H-1,2,3-triazol-1-yl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

4-morpholin-4-yl-N-{5-[5-(2H-1,2,3-triazol-2-yl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

N-(3-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}phenyl)ethane-1,2-diamine;

N-(3-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}phenyl)propane-1,3-diamine;

N,N-dimethyl-N′-(3-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}phenyl)ethane-1,2-diamine;

5-(2-{[4-(4-acetylpiperazin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2-aminoethyl)nicotinamide;

5-[2-({4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]nicotinic acid;

5-(2-{[4-(4-acetylpiperazin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-methylnicotinamide;

N-methyl-5-[2-({4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]nicotinamide;

N-(2-aminoethyl)-5-[2-({4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]nicotinamide;

N-methyl-5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-(2-{[4-(4-fluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinic acid;

5-(2-{[4-(4-fluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-methylnicotinamide;

N-(2-aminoethyl)-5-(2-{[4-(4-fluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

5-{2-[(4-piperidin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinic acid;

N-methyl-5-{2-[(4-piperidin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-[5-(3-bromophenyl)-1,3-thiazol-2-yl]-4-chloropyridin-2-amine;

5-{2-[(4-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

5-(2-{[4-(4-hydroxypiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

1-(2-{[5-(5-{[(2,2,2-trifluoroethyl)amino]carbonyl}pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperidin-4-ylmethanesulfonate;

3-{2-[(4-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}benzoic acid;

3-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)benzoic acid;

N-(2-aminoethyl)-3-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)benzamide;

5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

N-methyl-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(5-methyl-1,3-thiazol-2-yl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-1,3,4-thiadiazol-2-ylnicotinamide;

N-ethyl-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-acetamidyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N(3-aminopropyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-cyclopropyl-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-hydroxyethyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-[2-(methylamino)ethyl]-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-(2-{[4-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinic acid;

N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

5-(2-{[4-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-prop-2-yn-1-ylnicotinamide;

5-(2-{[4-(4-glycoloylpiperazin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

5-(2-{[4-(3,3-difluoroazetidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-(2-{[4-(3,3-difluoroazetidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

3-carboxy-5-(2-{[4-(3,3-difluoroazetidin-1-yl)pyridinium-2-yl]amino}-1,3-thiazol-5-yl)pyridinium;

5-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinic acid;

5-[2-({4-[4-(methylsulfonyl)piperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

tert-butyl [(2E)-3-(5-{2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)prop-2-en-1-yl]carbamate;

N-{5-[5-(3-aminopropyl)pyridin-3-yl]-1,3-thiazol-2-yl}-4-morpholin-4-ylpyridin-2-amine;

tert-butyl [(2E)-3-(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)prop-2-en-1-yl]carbamate;

5-(2-{[4-(1,1-dioxidothiomorpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(5-{5-[(1E)-3-aminoprop-1-en-1-yl]pyridin-3-yl}-1,3-thiazol-2-yl)-4-morpholin-4-ylpyridin-2-amine;

4-(2-{[5-(5-{[(2,2,2-trifluoroethyl)amino]carbonyl}pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazine-1-carboxamide;

N-methyl-4-(2-{[5-(5-{[(2,2,2-trifluoroethyl)amino]carbonyl}pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazine-1-carboxamide;

butyl 5-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinate;

N-(2-fluoroethyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoro-1-methylethyl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridine-2-carboxamide;

methyl 5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridine-2-carboxylate;

5-(2-{[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

4-morpholin-4-yl-N-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridine-2-carboxylic acid;

N-(2-aminoethyl)-5-{2-[(4-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridine-2-carboxamide;

5-(2-{[4-(4-fluoropiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(3-aminopropyl)-5-{2-[(4-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridine-2-carboxamide;

5-{2-[(4-piperidin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

4-morpholin-4-yl-N-{5-[5-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1,3-thiazol-2-yl}pyridin-2-amine;

tert-butyl (3-{[(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)carbonyl]amino}propyl)carbamate;

N-(2-aminoethyl)-5-{2-[(3-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(3-methylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinic acid;

N-(2-aminoethyl)-5-{2-[(3-methylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(3-methylpyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

5-{2-[(3-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(4-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(4,6-dimethylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinic acid;

5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinic acid;

5-{2-[(3-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinic acid;

N-(2-aminoethyl)-5-{2-[(4,6-dimethylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(3-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(2-chlorophenyl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]nicotinamide;

N-(2-aminoethyl)-5-{2-[(4-methylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(4,6-dichloropyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-(2-{[6-chloro-4-(trifluoromethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(3-bromopyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-(2-{[4-(dimethylamino)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

N-(2-aminoethyl)-5-[2-(quinolin-2-ylamino)-1,3-thiazol-5-yl]nicotinamide;

N-(2-aminoethyl)-5-[2-(isoquinolin-3-ylamino)-1,3-thiazol-5-yl]nicotinamide;

N-(2-aminoethyl)-5-[2-(isoquinolin-1-ylamino)-1,3-thiazol-5-yl]nicotinamide;

5-{2-[(3-methylquinolin-2-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(6-morpholin-4-ylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-{2-[(6-morpholin-4-ylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(6-chloropyrimidin-4-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-(2-{[6-(4,4-difluoropiperidin-1-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

5-{2-[(6-chloropyrimidin-4-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(5-methyl-6-morpholin-4-ylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-(2-{[6-(4,4-difluoropiperidin-1-yl)-5-methylpyrimidin-4-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

N-(2-aminoethyl)-5-{2-[(6-chloro-5-methylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-(2-{[6-(dimethylamino)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-methyl-4-(6-{[5-(5-{[(2,2,2-trifluoroethyl)amino]carbonyl}pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyrimidin-4-yl)piperazine-1-carboxamide;

5-[2-({6-[4-(methylsulfonyl)piperazin-1-yl]pyrimidin-4-yl}amino)-1,3-thiazol-5-yl]-N-(2,2,2-trifluoroethyl)nicotinamide;

5-{2-[(5-methyl-6-morpholin-4-ylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

5-{2-[(6-chloro-5-methylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl}-N-(2,2,2-trifluoroethyl)nicotinamide;

5-(2-{[6-(4,4-difluoropiperidin-1-yl)-5-methylpyrimidin-4-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-[2-(pyrazin-2-ylamino)-1,3-thiazol-5-yl]nicotinamide;

N-(2-aminoethyl)-5-{2-[(3,5-dimethylpyrazin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

N-(2-aminoethyl)-5-{2-[(3-chloropyrazin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamide;

5-(2-{[3-methyl-4-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

5-(2-{[4-(hydroxymethyl)-3-methylpyridin-2-yl]amino}-1,3-thiazol-5-yl)-N-(2,2,2-trifluoroethyl)nicotinamide;

N-(2-aminoethyl)-5-(2-{[3-(trifluoromethyl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)nicotinamide;

5-{2-[(3-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}-N-methoxy-N-methylnicotinamide;

1-(5-{2-[(3-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)ethanone; and

3-(5-{2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}pyridin-3-yl)propan-1-ol;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

4 . A pharmaceutical composition comprising a pharmaceutical carrier, and dispersed therein, a therapeutically effective amount of a compound of claim 1 .

5 . A method of treating cancer comprising the step of administering a therapeutically effective amount of the compound of claim 1 to a subject.

6 . (canceled)