Crystalline forms of MC4R agonist and process for synthesis
View Patent ↗The present invention relates to a process for producing N-{(1S)-1-[2-(1-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}piperidin-4-yl)-5-chlorophenyl]ethyl}acetamide, and novel crystalline salts, hydrates, solvates, and polymorphic forms thereof.
1. A crystalline mono hydrochloride salt of Compound I
which is a hydrate comprising from about 0.1 mole percent to about 6 mole percent of water.
2. The crystalline hydrate mono hydrochloride salt of Compound I of claim 1 having an x-ray powder diffraction pattern obtained using Cu radiation containing an angle 2 theta value of 14.1°.
3. The crystalline hydrate mono hydrochloride salt of Compound I of claim 1 having an x-ray powder diffraction pattern obtained using Cu radiation containing the following angle 2 theta values: 14.1° and 15.0°, and at least one angle theta value selected from the group consisting of: 19.5°, 17.9°, 10.5°, 15.4°, 28.1°, 18.4°, 18.2°, and 13.6°.
4. The crystalline hydrate mono hydrochloride salt of Compound I of claim 1 characterized by the X-ray powder diffraction pattern of FIG. 1 .
5. The crystalline hydrate mono hydrochloride salt of Compound I of claim 1 having an x-ray powder diffraction pattern obtained using Cu radiation characterized by a reflection at a d-spacing of about 5.0 angstroms.
6. The crystalline mono hydrochloride salt of Compound I of claim 1 having an x-ray powder diffraction pattern obtained using Cu radiation characterized by a reflection at a d-spacing of about 5.0 angstroms, and at least one additional reflection at a d-spacing determined by X-ray powder diffraction using Cu radiation of about 6.3, 5.9, 4.6, 10.0, 5.8, 3.4, 8.4, and 4.3 angstroms.
7. The crystalline mono hydrochloride salt of Compound I of claim 1 having an x-ray powder diffraction pattern obtained using Cu radiation characterized by reflections at a d-spacing of about 6.3, 5.9, and 4.6 angstroms.
8. The crystalline monohydrochloride salt of Compound I of claim 7 further comprising an x-ray powder diffraction pattern obtained using Cu radiation characterized by reflections at a d-spacing of about 10.0, 5.8, and 3.4 angstroms.
9. The crystalline monohydrochloride salt of Compound I of claim 8 further comprising an x-ray powder diffraction pattern obtained using Cu radiation characterized by reflections at a d-spacing of about 8.4, 5.0, and 4.3 angstroms.
10. The crystalline hydrate mono hydrochloride salt of Compound I of claim 1 having a differential scanning calorimetry (DSC) peak melting temperature of about 221° C.
11. A pharmaceutical composition comprising a therapeutically or prophylactically effective amount of the crystalline hydrate mono hydrochloride salt of Compound I of claim 1 , and a pharmaceutically acceptable carrier.