IP Library › Granted Patent US 7,919,579
Granted Patent B2
US 7,919,579 · App. 11/923,388 · Granted Apr 5, 2011

Imaging and therapeutic targeting of prostate and bladder tissues

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Quick Facts
Patent No.
US 7,919,579
App. No.
11/923,388
Granted
Apr 5, 2011
Kind
B2
Abstract

The present invention provides methods for imaging and the treatment of cancer. In certain embodiments, a polyarginine (e.g., R11) may be used to selectively image prostate or bladder cells (e.g., a metastatic prostate cancer). In other embodiments, a DOC-2/DAB2 peptide, optionally conjugated to a cell permeable peptide (e.g., R11) may be used to treat a cancer, such as prostate cancer.

Claims (3)

1. A pharmaceutical composition comprising R11 (SEQ ID NO: 6) conjugated to a Disabled Homolog 2 (DOC/DAB2) peptide.

2. The composition of claim 1 , wherein the DOC/DAB2 peptide comprises the sequence of SEQ ID NO:5.

3. The composition of claim 2 , wherein the DOC/DAB2 peptide consists essentially of the sequence of SEQ ID NO:5.

Assignments (2)
CONFIRMATORY LICENSE Recorded May 5, 2011
From: THE UNIVERSITY OF TEXAS SYSTEM
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 026223/0371 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 18, 2007
From: HSIEH, JER-TSONG; ZHOU, JIAN; SUN, XIANKAI
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 020260/0405 →