Devices and methods for treating defects in the tissue of a living being
View Patent ↗An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
1. A flowable implant for the repair or regeneration of tissue, said implant comprising an osteoconductive matrix and a depot of material, at least a portion of said matrix comprising native insoluble collagen fibers, said matrix possessing elastic recovery, said matrix further being compressed prior to the implant procedure, and said implant being arranged for implantation into said tissue of a body of a living being,
wherein said elastic recovery from said compression occurs following release into defect site, and wherein said elastic recovery causes said implant to conform to the shape of the defect being treated.
2. The implant of claim 1 , wherein said depot of material comprises at least one calcium salt.
3. The implant of claim 2 , further comprising a slurry of soluble collagen.
4. The implant of claim 3 , wherein said slurry of soluble collagen is arranged to suspend said native insoluble collagen fibers and said at least one calcium salt.
5. The implant of claim 4 , wherein said at least one calcium salt is in the form of particulate, and further wherein said depot of material assists in ingrowth of cells.
6. A flowable implant for the repair or regeneration of tissue, said implant comprising an osteoconductive matrix, wherein at least a portion of said matrix comprises native insoluble collagen, soluble collagen, and a calcium salt, wherein said calcium salt is at least one of calcium phosphate and calcium sulfate, said matrix possessing elastic recovery, wherein said implant is arranged to be implanted into a body of a living being, and further wherein said matrix is compressed prior to the implant procedure,
wherein said elastic recovery from said compression occurs following release into defect site, and wherein said elastic recovery causes said implant to conform to the shape of the defect being treated.
7. The implant of claim 6 , wherein in hydrated form said soluble collagen comprises a slurry, said slurry suspending said native insoluble collagen fibers and said calcium salt.
8. The implant of claim 7 , further comprising a depot of material that acts as a carrier for at least one other constituent.
9. The implant of claim 7 , wherein said depot of material comprises at least one of (i) said calcium salt, (ii) collagens, (iii) cytokines, and (iv) drugs.
10. A flowable implant for the repair or regeneration of tissue, said implant comprising an osteoconductive matrix, wherein at least a first portion of said matrix comprises a porous ceramic granule, wherein said porous ceramic is at least one of calcium phosphate and calcium sulfate, and at least a second portion of said matrix comprises a non-porous material, and at least a third portion of said matrix comprises native insoluble collagen, said matrix possessing elastic recovery, and further wherein said implant is arranged to be implanted into a body of a living being, and still further wherein said matrix is arranged to be compressed prior to the implant procedure,
wherein said elastic recovery from said compression occurs following release into defect site, and wherein said elastic recovery causes said implant to conform to the shape of the defect being treated.
11. A flowable multi-phasic implant for the repair and regeneration of tissue, said implant comprising an osteoconductive matrix composed of native insoluble collagen and components that resorb in stages wherein:
at least a first component is an insoluble ceramic granule; and
at least a second component is a non-porous collagen gel;
wherein the non-porous collagen gel suspends the granules, providing a level of structural integrity to the implant, said implant being arranged to be implanted into a body of a living being and further wherein the implant initially comprises ceramic granules which are in the form of a depot surrounded by lyophilized soluble collagen prior to implantation, said implant possesses a putty or paste consistency at a point of implantation, and still further wherein the lyophilized soluble collagen collapses into said non-porous gel upon hydration following implantation,
wherein said matrix possess elastic recovery, and wherein said matrix is arranged to be compressed prior to the implant procedure.