Method for operating a reservoir-based sensor device
View Patent ↗Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.
1. A method for operating a sensor device comprising;
providing at a site a device which comprises
at least a first reservoir and a second reservoir,
a first sensor and corresponding first reference sensor, which are located within the first reservoir,
a second sensor and corresponding second reference sensor, which are located within the second reservoir,
a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and
a power source, control circuitry, and electrodes for selectively disintegrating each of the first and second reservoir caps;
disintegrating the first reservoir cap and operating the first sensor and the corresponding first reference sensor; and
using the first reference sensor to determine whether the first sensor is operating properly.
2. The method of claim 1 , wherein upon determining that the first sensor is not operating properly, the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and the corresponding second reference sensor.
3. The method of claim 1 , wherein the step of disintegrating the first reservoir cap comprises the reservoir cap undergoing a phase change or chemical reaction.
4. The method of claim 3 , wherein the first and second reservoir caps each comprises a metal film.
5. The method of claim 1 , wherein the device is implanted in a patient.
6. The method of claim 1 , wherein the first and second sensors each comprise an electrode and a bioactive layer on said electrode.
7. The method of claim 6 , wherein the bioactive layer comprises an enzyme selected from the group consisting of glucose oxidase, glucose dehydrogenase, NADH oxidase, uricase, urease, creatininase, sarcosine oxidase, creatinase, creatine kinase, creatine amidohydrolase, cholesterol esterase, cholesterol oxidase, glycerol kinase, hexokinase, glycerol-3-phosphate oxidase, lactate dehydrogenase, alkaline phosphatase, alanine transaminase, aspartate transaminase, amylase, lipase, esterase, gamma-glutamyl transpeptidase, L-glutamate oxidase, pyruvate oxidase, diaphorase, bilirubin oxidase, and mixtures thereof.