Optimized Fc variants and methods for their generation
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
1. An antibody or immunoadhesin, wherein said antibody or immunoadhesin comprises an Fc variant of a human parent Fc polypeptide, said Fc variant comprising an amino acid substitution at position 299 in the Fc region and wherein numbering is according to the EU index.
2. A protein comprising an Fc variant of a human parent Fc polypeptide, said Fc variant comprising an amino acid substitution at position 299 in the Fc region and wherein numbering is according to the EU index.
3. The antibody or immunoadhesin of claim 1 , wherein said amino acid substitution is 299A.
4. The protein of claim 2 , wherein said amino acid substitution is 299A.