PRO1550 polypeptides
View Patent ↗The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
1. An isolated polypeptide comprising an amino acid sequence having at least 95% amino acid sequence identity to (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide, (c) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, or (d) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, lacking its associated signal peptide; wherein said isolated polypeptide can be used to generate an antibody which can be used to specifically detect the polypeptide of SEQ ID NO: 2 in esophageal, stomach, lung, or rectal tissue samples.
2. A chimeric molecule comprising a polypeptide according to claim 1 fused to a heterologous amino acid sequence.
3. The chimeric molecule of claim 2 , wherein said heterologous amino acid sequence is an epitope tag sequence.
4. The chimeric molecule of claim 2 , wherein said heterologous amino acid sequence is a Fc region of an immunoglobulin.
5. An isolated polypeptide of claim 1 comprising an amino acid sequence having at least 99% amino acid sequence identity to (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide, (c) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, or (d) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, lacking its associated signal peptide; wherein said isolated polypeptide can be used to generate an antibody which can be used to specifically detect the polypeptide of SEQ ID NO: 2 in esophageal, stomach, lung, or rectal tissue samples.
6. The isolated polypeptide of claim 1 comprising (a) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), (b) the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide, (c) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, or (d) the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, lacking its associated signal peptide.
7. The isolated polypeptide of claim 6 comprising the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2).
8. The isolated polypeptide of claim 6 comprising the amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO:2), lacking its associated signal peptide.
9. The isolated polypeptide of claim 6 comprising the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323.
10. The isolated polypeptide of claim 6 comprising the amino acid sequence of the full-length polypeptide encoded by the cDNA deposited under ATCC Accession No. 203323, lacking its associated signal peptide.