Kallikrein-inhibitor therapies
View Patent ↗Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient.
1. A method for reducing blood loss in a patient, the method comprising administering to the patient a composition comprising an effective amount of a kallikrein inhibitor, wherein the inhibitor comprises a polypeptide that comprises the amino acid sequence of SEQ ID NO:57.
2. The method of claim 1 , wherein the blood loss is perioperative blood loss due to a surgical procedure performed on the patient.
3. The method of claim 2 , wherein the surgical procedure is a cardiothoracic surgery.
4. The method of claim 3 , wherein the cardiothoracic surgery is cardiopulmonary bypass or coronary artery bypass grafting.
5. The method of claim 1 , wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:2.
6. The method of claim 1 , wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:57.
7. The method of claim 1 , wherein the polypeptide consists of the amino acid sequence of SEQ ID NO:2.
8. The method of claim 3 , wherein the cardiothoracic surgery is pediatric cardiothoracic surgery.
9. The method of claim 2 , wherein the surgical procedure is hip replacement surgery.
10. The method of claim 2 , wherein the surgical procedure is lung transplantation.
11. The method of claim 2 , wherein the surgical procedure is an orthopic liver transplant.
12. The method of claim 2 , wherein the surgical procedure is a procedure utilizing extracorporeal circulation.
13. The method of claim 2 , wherein the polypeptide is administered prior to the surgical procedure.
14. The method of claim 2 , wherein the polypeptide is administered during the surgical procedure.
15. The method of claim 2 , wherein the polypeptide is administered after the surgical procedure.