Diagnostic technique for determining oncogenic signature indicative of tumorous growth
A priori knowledge is obtained from known tumor samples, indicative of cellular pathways associated with those known tumor samples. Multiple pathways are found for each tumor. This becomes a priori knowledge. Later unknown tumor samples are then analyzed against the a priori knowledge to find the pathways etc within the unknown tumor samples. Multiple pathways are collected to form an oncogenic signature. The oncogenic signature is used to find a cocktail of multiple treatments that treats each of the multiple pathways.
1 . A method, comprising:
accessing information indicative of plural different cellular pathways, each of which plural different cellular pathways are responsible for at least one aspect of a tumor;
analyzing a specific tumor sample, to identify which of said plural different cellular pathways are active therein;
finding multiple of said different cellular pathways associated with said specific tumor sample, and forming an oncogenic signature indicative of said multiple different cellular pathways; and
using said oncogenic signature to determine treatments, where said treatments include multiple different treatments which collectively treat each of said multiple different cellular pathways.
2 . A method as in claim 1 , further comprising obtaining information about said cellular pathways from a gene array.
3 . A method as in claim 1 , wherein said analyzing comprises deducing said cellular pathways using known information.
4 . A method as in claim 1 , wherein said using comprises using a rule-based technique to look up a treatment based on which of said pathways are active, by determining at least multiple pathways which are active, and using said multiple pathways to access a rule in the form of if said multiple pathways are active, then use treatment A.
5 . A method as in claim 1 , further comprising identifying a specific tumor sample which has none of said cellular pathways being active, and further analyzing said specific tumor sample to determine new cellular pathways therein.
6 . A method as in claim 1 , wherein said obtaining comprises obtaining information associated with a first number of analyses, and said analyzing comprises obtaining information from a second number of analyses less than said first number now.
7 . A method, comprising:
first analyzing plural known tumor samples to determine cellular pathways associated with said known tumor samples as a priori knowledge; and
second analyzing at least one unknown tumor sample, to determine plural different cellular pathways are responsible for at least one aspect of a tumor based on said a priori knowledge,
wherein a number of tests on said known tumor samples is at least ten times greater than a number of tests on said unknown tumor samples; and
using said plural different cellular pathways to find plural different treatments for said unknown tumor sample, each of which treatments is directed to a specific single one of said cellular pathways; and
providing said plural treatments to treat said unknown tumor sample.
8 . A method as in claim 7 , wherein said first and second analyzing comprises obtaining information about said cellular pathways from a gene array.
9 . A method as in claim 7 , wherein said using comprises using a rule-based technique to look up a treatment based on which of said pathways are active, by determining at least multiple pathways which are active, and using said multiple pathways to access a rule set in the form of if multiple pathways A and B are active, then use treatment C and D.
10 . A method as in claim 7 , further comprising identifying a specific tumor sample which has none of said cellular pathways being active, and further analyzing said specific tumor sample to determine new cellular pathways therein.
11 . A method as in claim 1 , wherein said obtaining comprises obtaining information associated with a first number of analyses, and said analyzing comprises obtaining information from a second number of analyses less than said first number now.
12 . A testing apparatus, comprising:
a computer, having stored therein, information indicative of plural different cellular pathways, each of which plural different cellular pathways are responsible for at least one aspect of a tumor;
a gene analysis part, analyzing a specific tumor sample, to identify which of said plural different cellular pathways are active therein;
said computer finding multiple of said different cellular pathways associated with said specific tumor sample, and forming an oncogenic signature indicative of said multiple different cellular pathways, and using said oncogenic signature to determine treatments, where said treatments include multiple different treatments which collectively treat each of said multiple different cellular pathways.