Canine lyme disease vaccine
The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective agents.
1. A vaccine composition comprising an immunologically effective amount of B. burgdorferi ss 50772 (ATCC No. PTA-439) and B. burgdorferi ss S-1-10 (ATCC No. PTA-1680).
2. The vaccine of claim 1 , wherein the immunologically effective amount of B. burgdorferi ss 50772 (ATCC No. PTA-439) and B. burgdorferi ss S-1-10 (ATCC No. PTA-1680) have been inactivated.
3. The vaccine composition of claim 2 comprising from about 1×10 4 to about 1×10 10 organisms per milliliter of B. burgdorferi ss 50772 and from about 1×10 4 to about 1×10 10 organisms per milliliter of B. burgdorferi ss S-1-10.
4. The vaccine composition of claim 3 comprising from about 5.0×10 8 to about 5×10 9 organisms per milliliter of B. burgdorferi as 50772 and from about 1.0×10 8 to about 5×10 8 organisms per milliliter of B. burgdorferi ss S-1-10.
5. The vaccine composition of claim 2 further comprising a pharmaceutically acceptable adjuvant.
6. The vaccine composition of claim 2 further comprising a pharmaceutically acceptable immune stimulant.