Tweak binding antibodies
View Patent ↗Anti-Tweak antibodies are described.
1. A humanized antibody that binds to human TWEAK or an antigen binding fragment thereof comprising:
a) heavy chain variable domain complementarity determining regions (CDRs), wherein
CDR1 comprises the amino acid sequence set forth in SEQ ID NO:4;
CDR2 comprises the amino acid sequence set forth in SEQ ID NO:5; and
CDR3 comprises an amino acid sequence set forth in SEQ ID NO:6, or SEQ ID NO:7; and
b) light chain variable domain CDRs, wherein
CDR1 comprises an amino acid sequence set forth in SEQ ID NO:11;
CDR2 comprises an amino acid sequence set forth in SEQ ID NO:13; and
CDR3 comprises an amino acid sequence set forth in SEQ ID NO:15.
2. The humanized antibody or antigen binding fragment of claim 1 , wherein the heavy chain CDRS1-3 have the amino acid sequences set forth in SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3, respectively.
3. The humanized antibody or antigen binding fragment of claim 1 , wherein the light chain CDRS1-3 have the amino acid sequences set forth in SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10, respectively.
4. A humanized antibody that binds to human TWEAK or an antigen binding fragment thereof comprising heavy chain CDRS1-3 that have the amino acid sequences set forth in SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3, respectively and light chain CDRS1-3 that have the amino acid sequences set forth in SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:10, respectively.