Influenza vaccine formulation
View Patent ↗Peptide-based anti-influenza formulations against influenza are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formulations can be used to prepare vaccines for preventing influenza, particularly avian influenza.
1. A peptide-based immunogenic composition comprising a peptide which is SEQ ID NO: 1.
2. The composition of claim 1 further comprising at least one peptide selected from the group consisting of SEQ ID NOs: 2 to 24.
3. The composition of claim 1 further comprising a pharmaceutically-acceptable diluent or carrier.
4. The composition of claim 3 further comprising an adjuvant.
5. The composition of claim 4 wherein the adjuvant is alum.
6. An immunogenic composition comprising a mixture of isolated peptides selected from the group consisting of SEQ ID NOs: 1 to 24, said peptides representing variants of at least one variable region of an avian influenza virus HA or HA1 protein, wherein each of said variable regions comprises one or more variable amino acid residues, at least one of said variable amino acid residues is represented by two or more amino acids.
7. The immunogenic composition of claim 6 , wherein said one or more variable amino acid residues is represented by three or more amino acids.
8. The immunogenic composition of claim 6 , further comprising a peptide selected from the group consisting of SEQ ID NOs: 25 to 40.
9. The composition of claim 1 , further comprising a peptide selected from the group consisting of SEQ ID NOs: 25 to 40.
10. The composition of claim 1 , comprising peptides of SEQ ID NOs: 1 to 24.
11. The composition of claim 1 , comprising peptides of SEQ ID NOs: 1 to 40.