Method of making demineralized bone particles

1. A method of making demineralized bone particles for use as or in an osteoimplant, which comprises demineralizing whole bone and thereafter subdividing the demineralized bone into demineralized bone particles, wherein subdividing of the demineralized bone is carried out by providing a pressing motion to the whole bone by application of at least one rolling pin, and wherein the subdivided demineralized bone comprises substantially intact natural bone collagen fibers having lengths that are nearly as great as lengths of natural fibers of the whole bone.

2. The method of claim 1 , wherein the whole bone is cortical allogenic bone.

3. The method of claim 1 , wherein the whole bone is partially demineralized.

4. The method of claim 1 , wherein the whole bone is partially demineralized to contain less than about 10% by weight residual calcium.

5. The method of claim 1 , wherein the whole bone is partially demineralized to contain less than about 5% by weight residual calcium.

6. The method of claim 1 ,wherein the whole bone is partially demineralized to contain less than about 1% by weight residual calcium.

7. The method of claim 1 , wherein the bone is subjected to pressing while unconstrained.

8. A method of making demineralized bone particles for use as or in an osteoimplant, which comprises demineralizing whole bone and thereafter subdividing the demineralized bone into demineralized bone particles, wherein subdividing of the demineralized bone is carried out by providing a pressing motion to the whole bone by application of at least one roller, and wherein the subdivided demineralized bone comprises substantially intact natural bone collagen fibers having lengths that are nearly as great as lengths of natural fibers of the whole bone.

9. The method of claim 8 , wherein the whole bone is cortical allogenic bone.

10. The method of claim 8 , wherein the whole bone is partially demineralized.

11. The method of claim 8 , wherein the whole bone is partially demineralized to contain less than about 10% by weight residual calcium.

12. The method of claim 8 , wherein the whole bone is partially demineralized to contain less than about 5% by weight residual calcium.

13. The method of claim 8 ,wherein the whole bone is partially demineralized to contain less than about 1% by weight residual calcium.

14. The method of claim 8 , wherein the bone is subjected to pressing while unconstrained.

15. A method of making demineralized bone particles for use as or in an osteoimplant, which comprises demineralizing whole bone and thereafter subdividing the demineralized bone into demineralized bone particles, wherein subdividing of the demineralized bone is carried out by pressing the whole bone between curved plates, and wherein the subdivided demineralized bone comprises substantially intact natural bone collagen fibers having lengths that are nearly as great as lengths of natural fibers of the whole bone.

16. The method of claim 15 , wherein the whole bone is cortical allogenic bone.

17. The method of claim 15 , wherein the whole bone is partially demineralized.

18. The method of claim 15 , wherein the whole bone is partially demineralized to contain less than about 10% by weight residual calcium.

19. The method of claim 15 , wherein the whole bone is partially demineralized to contain less than about 5% by weight residual calcium.

20. The method of claim 15 ,wherein the whole bone is partially demineralized to contain less than about 1% by weight residual calcium.

21. The method of claim 15 , wherein the bone is subjected to pressing while unconstrained.