Biologic artificial bone
View Patent ↗A biologic artificial bone includes an artificial fiber material formed from a synthetic polymer with mechanical properties similar to type I collagen. A biocompatible liquid substance is impregnated in the fiber material that hardens and stiffens the fiber material. A bone substitute is impregnated in the hardened and stiffened fiber material forming an artificial bone composite. Vascular channels are formed in the artificial bone composite to facilitate in-growth of vessels and bone forming cells. The construction and methods achieve an artificial composite structure that is similar to natural bone with comparable properties.
1. A biologic artificial bone comprising:
an artificial fiber material formed from a synthetic polymer with mechanical properties similar to type I collagen, wherein the artificial fiber material is formed into a cast shaped corresponding to a human bone or a bone implant, and wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in multiple orientations in a single sheet, wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in horizontal, vertical and oblique orientations;
a biocompatible liquid substance impregnated in the fiber material, the biocompatible liquid substance hardening and stiffening the fiber material;
a bone substitute impregnated in the hardened and stiffened fiber material forming an artificial bone composite, wherein the artificial bone composite has structural characteristics by virtue of the artificial fiber cast, biocompatible liquid substance and the bone substitute such that the artificial bone composite retains its shape after installation; and
vascular channels formed in the artificial bone composite prior to installation to facilitate in-growth of vessels and bone forming cells.
2. A biologic artificial bone according to claim 1 , wherein the bone substitute comprises ceramics.
3. A biologic artificial bone according to claim 1 , wherein the channels are coated with angiogenic factors.
4. A biologic artificial bone according to claim 1 , wherein the artificial bone composite is wrapped with a porous sheet of absorbable material having dissolvable spikes of variable density on one side thereof, the porous sheet being wrapped on the artificial bone composite with the spikes facing inward to penetrate the artificial bone composite, thereby creating the vascular channels for vascular in-growth after implantation of the biologic artificial bone.
5. A biologic artificial bone according to claim 1 , further comprising a single or multiple stumps of the artificial fiber material in continuity with the artificial bone composite for attachment of tendons after implantation of the biologic artificial bone.
6. A biologic artificial bone according to claim 1 , further comprising a trabecular network of ceramic plates augmented with a polymer network that confer compressive strength to ends of the artificial bone.
7. A biologic artificial bone comprising:
an artificial fiber material formed from a synthetic polymer with mechanical properties similar to type I collagen, wherein the artificial fiber material is formed into a cast shaped corresponding to a human bone or a bone implant, and wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in multiple orientations in a single sheet, wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in vertical, horizontal and spiral orientations defining a concentric cylindrical arrangement of fibers;
a biocompatible liquid substance impregnated in the fiber material, the biocompatible liquid substance hardening and stiffening the fiber material;
a bone substitute impregnated in the hardened and stiffened fiber material forming an artificial bone composite, wherein the artificial bone composite has structural characteristics by virtue of the artificial fiber cast, biocompatible liquid substance and the bone substitute such that the artificial bone composite retains its shape after installation; and
vascular channels formed in the artificial bone composite prior to installation to facilitate in-growth of vessels and bone forming cells.
8. A biologic artificial bone according to claim 7 , wherein the bone substitute comprises ceramics.
9. A biologic artificial bone according to claim 7 , wherein the channels are coated with angiogenic factors.
10. A biologic artificial bone according to claim 7 , wherein the artificial bone composite is wrapped with a porous sheet of absorbable material having dissolvable spikes of variable density on one side thereof, the porous sheet being wrapped on the artificial bone composite with the spikes facing inward to penetrate the artificial bone composite, thereby creating the vascular channels for vascular in-growth after implantation of the biologic artificial bone.
11. A biologic artificial bone according to claim 7 , further comprising a single or multiple stumps of the artificial fiber material in continuity with the artificial bone composite for attachment of tendons after implantation of the biologic artificial bone.
12. A biologic artificial bone according to claim 7 , further comprising a trabecular network of ceramic plates augmented with a polymer network that confer compressive strength to ends of the artificial bone.
13. A biologic artificial bone comprising:
an artificial fiber material formed from a synthetic polymer with mechanical properties similar to type I collagen, wherein the artificial fiber material is formed into a cast shaped corresponding to a human bone or a bone implant, and wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in multiple orientations in a single sheet, wherein the artificial fiber material comprises fibers formed in a fiber network with fibers arranged in vertical, horizontal and spiral orientations defining a fibrous sheet rolled into a multilayer cylinder;
a biocompatible liquid substance impregnated in the fiber material, the biocompatible liquid substance hardening and stiffening the fiber material;
a bone substitute impregnated in the hardened and stiffened fiber material forming an artificial bone composite, wherein the artificial bone composite has structural characteristics by virtue of the artificial fiber cast, biocompatible liquid substance and the bone substitute such that the artificial bone composite retains its shape after installation; and
vascular channels formed in the artificial bone composite prior to installation to facilitate in-growth of vessels and bone forming cells.
14. A biologic artificial bone according to claim 13 , wherein the bone substitute comprises ceramics.
15. A biologic artificial bone according to claim 13 , wherein the channels are coated with angiogenic factors.
16. A biologic artificial bone according to claim 13 , wherein the artificial bone composite is wrapped with a porous sheet of absorbable material having dissolvable spikes of variable density on one side thereof, the porous sheet being wrapped on the artificial bone composite with the spikes facing inward to penetrate the artificial bone composite, thereby creating the vascular channels for vascular in-growth after implantation of the biologic artificial bone.
17. A biologic artificial bone according to claim 13 , further comprising a single or multiple stumps of the artificial fiber material in continuity with the artificial bone composite for attachment of tendons after implantation of the biologic artificial bone.
18. A biologic artificial bone according to claim 13 , further comprising a trabecular network of ceramic plates augmented with a polymer network that confer compressive strength to ends of the artificial bone.