Dihydropyridine derivatives as useful as protein kinase inhibitors
View Patent ↗This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
1. A compound having the formula
wherein
R 3 is a cyano group;
R 4 is C 1-3 alkyl or haloalkyl;
R 5 is hydrogen;
R 6 is C 1-3 alkyl;
R 11 is C 1-3 alkyl;
and
R 12 is hydrogen,
or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein R 4 is C 1-3 alkyl.
3. A compound according to claim 1 , wherein R 4 is methyl.
4. A compound according to claim 1 , wherein R 6 is methyl.
5. A compound according to claim 1 , wherein R 11 is methyl.
6. A compound according to claim 1 , wherein R 4 and R 6 are C 1-3 alkyl.
7. A compound according to claim 1 , wherein R 4 and R 6 are methyl.
8. A compound according to claim 1 , wherein R 6 and R 11 are methyl.
9. A compound according to claim 1 , which is 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1H-indazol-5-yl)-3,5-pyridinedicarbonitrile, or a pharmaceutically acceptable salt thereof.
10. A compound having the formula