Treatment of infected tissues with hypochlorous acid
View Patent ↗Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.
1. A method for disinfecting a mammalian tissue comprising dermal fibroblasts, the method comprising:
administering a hypochlorous acid formulation to said tissue in an amount effective to act as a microbiocide without inhibiting growth of said dermal fibroblasts;
wherein the formulation is obtained by (i) electrolysis of an aqueous saline solution to provide an output hypochlorous acid solution having an available free chlorine concentration of 144 mg/L to 400 mg/L and a redox potential of >950 mV, and (ii) diluting said output solution and adjusting its pH such that the pH is within 5 to 7.
2. The method of claim 1 , wherein the mammalian tissue comprises a surface or open wound.
3. The method of claim 2 , wherein the mammalian tissue comprises a leg ulcer.
4. The method of claim 1 , wherein the mammalian tissue comprises a burn.
5. The method of claim 3 or 4 , wherein the formulation has a pH of about 5.4 or about 6.2.
6. The method of claim 1 , wherein the formulation is formulated as a gel.
7. The method of claim 1 , wherein the output hypochlorous acid solution is produced in an electrochemical cell having electrodes separated by a semi-permeable membrane.
8. The method of claim 1 , wherein the mammalian tissue further comprises keratinocytes.