Registration of optical images of turbid media
View Patent ↗A co-registration system provides a means for spatially warping an optical image of an object with another images of a similar object. The optical image may be a scatter image, and the second image may be the same type of image modality, or may be different. The co-registration may use landmarks selected by a user, or may make use of contour information derived from the images. The system may also include processing of three-dimensional volume data in the form of sets of two-dimensional slices for co-registration.
1. A system for providing co-registration between a first digital image of an object derived by means of diffuse photon propagation through the object and a second digital image of the object, the second digital image of the object having a configuration similar to a configuration of the first digital image of the object, the system comprising:
a database for storing the first and second digital images of the object, wherein the first and second digital images of the object represent a same part of the object;
a graphical user interface for allowing a user to:
view the first and second digital images of the object,
select N first data points of the object in the first digital image of the object for identifying N features of the object, and
select in the second digital image of the object N second data points of the object, corresponding to the N first data points of the object, for identifying the N features of the object; and
a co-registration module for enabling a spatial warping of one of the first and second digital images of the object with respect to the other one of the first and second digital images of the object by a compression or an extension of the first digital image of the object, along at least one axis defined by two or more of the N first data points, or by a compression or an extension of the second digital image of the object, along at least one axis defined by two or more of the N second data points, so that at least M of the N features of the object on the one of the first and second digital images of the object are mapped to corresponding at least M of the N features of the object on the other one of the first and second digital images of the object.
2. The system of claim 1 , wherein the same part of the object correspond to slices of 3D images of the object.
3. The system of claim 1 , wherein the graphical user interface further allows the user to select points along a contour of the object of the first and second images.
4. The system of claim 1 , wherein the second image is a digital X-ray mammography image.
5. The system of claim 1 , wherein the object is a human breast.
6. The system of claim 1 , wherein the co-registration module is for defining a transform function for deriving data point coordinates of one of the first and second images from data point coordinates from another one of the first and second images.
7. The system of claim 6 , wherein the co-registration module is for defining an inverse of the transform function for deriving data point coordinates of the first image from data point coordinates of the second image.
8. The system of claim 6 , wherein the co-registration module is for applying the transform function to a plurality of image pairs, wherein each image pair comprises a third image derived from another diffuse photon propagation of the object in a plane parallel to the first image and a fourth image with a configuration similar to a configuration of the third image.
9. The system of claim 1 , wherein the database is further for storing a spatially warped image.
10. The system of claim 1 , comprising a display for showing a spatially warped image.
11. A method for providing co-registration between a first digital image of an object derived by means of diffuse photon propagation through the object and a second digital image of the object having a configuration similar to a configuration of the first image of the object, comprising:
storing the first and second digital images of the object in a database, wherein the first and second digital images of the object represent a same part of the object;
allowing a user to view the first and second digital images of the object, to select N first data points for identifying N features of the object, and to select in the second digital image of the object N second data points of the object, corresponding to the N first data points of the object, for identifying the N features of the object; and
spatially warping one of the first and second images with respect to the other one of the first and second images by compressing or extending the first digital image of the object, along at least one axis defined by two or more of the N first data points, or by compressing or extending the second digital image of the object, along at least one axis defined by two or more of the N second data points, so that at least M of the N features of the object on the one of the first and second digital images of the object are mapped to corresponding at least M of the N features of the object on the other one of the first and second digital images of the object.
12. The system of claim 1 , wherein the N first data points of the object and the N second data points of the object comprise landmark points of the object of the first and second images.
13. The system of claim 1 , wherein the N first data points of the object and the N second data points of the object comprise contour data of the object of the first and second images.
14. The system of claim 1 , wherein the co-registration module is configured to:
define a first reference axis based on two of the N first data points identifying two of the N features of the object,
define a second reference axis based on two of the N second data points identifying the two of the N features of the object,
compute a ratio of a distance between the two first data points and a distance between the two second data points, and
compress or extend the first digital image, along the first reference axis, or compress or extend the second digital images of the object, along the second reference axis, as a function of the ratio.
15. The system of claim 14 , wherein:
the graphical user interface is configured to allow the user to select third and fourth first data points in the first digital image of the object and corresponding third and fourth second data points in the second digital image of the object for identifying third and fourth features of the object; and
the co-registration module is configured to define a third reference axis, perpendicular to the first reference axis, based on the third and on the fourth first data points and to define a fourth reference axis, perpendicular to the second reference axis, based on the third and on the fourth second data points.
16. The system of claim 15 , wherein the co-registration module is configured to:
compute a first coordinate of the third feature of the object in the first image of the object as a fraction of a distance between the third first data point and a meeting point of the first and third reference axes over a distance between the fourth first data point and the meeting point of the first and third reference axes;
compute a second coordinate of the third feature of the object in the first image of the object as a fraction of a distance between one of the first data points and the meeting point of the first and third reference axes over the distance between the two first data points;
compute a first coordinate of the third feature of the object in the second image of the object as a fraction of a distance between the third first data point and a meeting point of the second and fourth reference axes over a distance between the fourth second data point and the meeting point of the second and fourth reference axes; and
compute a second coordinate of the third feature of the object in the second image of the object as a fraction of a distance between one of the second data points and the meeting point of the second and fourth reference axes over the distance between the two second data points.