Biochemical analyzer and method of controlling internal temperature of the biochemical analyzer
View Patent ↗Provided is a biochemical analyzer in which a microfluidic biochemical assay may be performed. The analyzer includes: a microfluidic device loading space including a microfluidic device supporting unit detachably supporting a microfluidic device including an energy application region in which an energy is applied; an energy source loading space including an energy source applying the energy to the radiation application region; and an isolation wall isolating the microfluidic device loading space and the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space and including a window through which the energy can be transmitted. A method of controlling an internal temperature of the biochemical analyzer is also provided.
1. A biochemical analyzer comprising:
a microfluidic device loading space which receives a microfluidic device, the microfluidic device loading space comprising a microfluidic device supporting unit detachably supporting the microfluidic device;
an energy source loading space which receives an energy source, the energy source applying the energy to the microfluidic device
an isolation wall isolating the microfluidic device loading space from the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space, the isolation wall comprises a window through which the energy can be transmitted; and
an optical detector which optically detects a reaction in the microfluidic device.
2. The biochemical analyzer of claim 1 , wherein the microfluidic device supporting unit comprises a motor which rotates the microfluidic device.
3. The biochemical analyzer of claim 1 , wherein the energy source comprises a laser diode (LD).
4. The biochemical analyzer of claim 3 , further comprising an energy source movement unit which horizontally moves the energy source.
5. The biochemical analyzer of claim 1 , wherein the microfluidic device loading space further comprises a heater for heating the microfluidic device.
6. The biochemical analyzer of claim 5 , wherein the microfluidic device loading space further comprises a first temperature sensor for measuring a temperature of the microfluidic device loading space, and
wherein the heater is operated, if a temperature measured by the first temperature sensor is lower than a first reference temperature.
7. The biochemical analyzer of claim 6 , wherein the first reference temperature is about from 36° C. to about 38° C.
8. The biochemical analyzer of claim 6 , further comprising a first cooler for lowering the temperature of the microfluidic device loading space,
wherein the first cooler is operated, if the temperature measured by the first temperature sensor is higher than the first reference temperature.
9. The biochemical analyzer of claim 8 , wherein the first cooler comprises an inlet fan for inducing external air to flow into the microfluidic device loading space.
10. The biochemical analyzer of claim 9 , wherein the first cooler further comprises a filter for filtering particles contained in the external air entering into the microfluidic device loading space.
11. The biochemical analyzer of claim 1 , further comprising a second cooler for lowering the temperature of the energy source loading space.
12. The biochemical analyzer of claim 11 , wherein the energy source loading space further comprises a second temperature sensor for measuring the temperature of the energy source loading space, and
wherein the second cooler is operated, if a temperature measured by the second temperature sensor is higher than a second reference temperature.
13. The biochemical analyzer of claim 12 , wherein the second cooler comprises an energy source cooling fan for lowering the temperature of the energy source by inducing external air to flow into the energy source loading space.
14. The biochemical analyzer of claim 13 , wherein the second cooler comprises an energy source cooling duct for guiding the external air into the energy source.
15. The biochemical analyzer of claim 12 , wherein the second reference temperature is about 25° C.
16. The biochemical analyzer of claim 1 , wherein the isolation wall except at least the window is formed of a plastic material.
17. The biochemical analyzer of claim 1 , wherein the window is formed of a glass, crystal, or plastic.
18. The biochemical analyzer of claim 17 , wherein anti-reflect coating is applied to a surface of the window.
19. A biochemical analyzer comprising:
a microfluidic device loading space which receives a microfluidic device, the microfluidic device loading space comprising a microfluidic device supporting unit detachably supporting the microfluidic device;
an energy source loading space which receives an energy source, the energy source applying the energy to the microfluidic device
a wall isolating the microfluidic device loading space from the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space, the wall comprises a window through which the energy can be transmitted; and
an optical detector which optically detects a reaction in the microfluidic device.