Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption
View Patent ↗The invention relates generally to digestive disorders, and in particular to methods for treating irritable bowel syndrome by increasing carbohydrate absorption by administering a composition containing a Bacillus coagulans bacterium.
1. A method of reducing a symptom of irritable bowel syndrome, comprising the steps of: identifying a subject having a symptom of irritable bowel syndrome; and providing a composition comprising an effective amount of viable Bacillus coagulans bacterial spores to said subject, wherein said bacterial spores are from Bacillus coagulans selected from the group consisting of GBI-20 (ATCC Designation Number PTA-6085), GBI-30 (ATCC Designation Number PTA-6086), and GBI-40 (ATCC Designation Number PTA-6087), wherein said composition comprising Bacillus coagulans is administered orally, and wherein a symptom of irritable bowel syndrome in said subject is reduced following said administration.
2. The method of claim 1 , wherein said composition further comprises a supplementary enzyme, wherein said enzyme is selected from the group consisting of a lactase, a fructase, a lipase, an amylase and a protease.
3. The method of claim 1 , wherein said symptom is gas or bloating.
4. The method of claim 1 , wherein said composition further comprises an anti-gas agent.
5. The method of claim 4 , wherein said anti-gas agent is selected from the group of α-galactosidase enzyme, simethicone, calcium carbonate, aluminum hydroxide and magnesium hydroxide.
6. The method of claim 1 , wherein said composition comprises about 1×10 8 to about 1×10 10 Bacillus coagulans bacterial spores.
7. A method of reducing a symptom of irritable bowel syndrome (IBS), comprising identifying a subject suffering from irritable bowel syndrome, and orally administering to said subject a composition comprising an effective IBS-inhibiting amount of Bacillus coagulans bacterial spores prior to or concomitant with the onset of one or more IBS symptoms, wherein said bacterial spores are from Bacillus coagulans selected from the group consisting of GBI-20 (ATCC Designation Number PTA-6085), GBI-30 (ATCC Designation Number PTA-6086), and GBI-40 (ATCC Designation Number PTA-6087), wherein said composition comprising Bacillus coagulans is administered orally, and wherein a symptom of irritable bowel syndrome in said subject is reduced following said administration.
8. The method of claim 7 , wherein said composition further comprises a supplementary enzyme, wherein said enzyme is selected from the group consisting of a lactase, a fructase, a lipase, an amylase, and a protease.
9. The method of claim 7 , wherein said composition comprises about 1×10 8 to about 1×10 10 Bacillus coagulans spores.
10. The method of claim 1 , wherein the subject is a human.
11. The method of claim 7 , wherein the subject is a human.
12. The method of claim 1 , wherein said Bacillus coagulans is GBI-30 strain (ATCC Designation Number PTA-6086).
13. The method of claim 7 , wherein said Bacillus coagulans is GBI-30 strain (ATCC Designation Number PTA-6086).
14. A method of claim 1 , wherein said composition comprises a ratio of Bacillus coagulans bacterial spores to vegetative cells of approximately 80:20.
15. The method of claim 7 , wherein said composition comprises a ratio of Bacillus coagulans bacterial spores to vegetative cells of approximately 80:20.
16. The method of claim 1 , wherein said composition comprises about 1×10 4 to about 1×10 12 Bacillus coagulans bacterial spores.
17. The method of claim 7 , wherein said composition comprises about 1×10 4 to about 1×10 12 Bacillus coagulans bacterial spores.
18. The method of claim 1 , wherein said composition comprises about 1×10 6 to about 1×10 11 Bacillus coagulans bacterial spores.
19. The method of claim 1 , wherein said composition comprises about 8.0×10 8 Bacillus coagulans bacterial spores.
20. The method of claim 7 , wherein said composition comprises about 1×10 6 to about 1×10 11 Bacillus coagulans bacterial spores.
21. The method of claim 7 , wherein said composition comprises about 8.0×10 8 Bacillus coagulans bacterial spores.