4-Chromenonyl-1,4-dihydropyridines and their use

1. A compound of the formula (I)

in which

R 1 and R 2 are identical or different and are independently of one another (C 1 -C 4 )-alkyl, trifluoromethyl, cyclopropyl or cyclobutyl,

R 3 is (C 3 -C 7 )-cycloalkyl, is (C 1 -C 6 )-alkyl which may be substituted by (C 3 -C 7 )-cycloalkyl or once to three times by fluorine, or is phenyl which may be substituted by halogen, cyano, (C 1 -C 4 )-alkyl, trifluoromethyl, (C 1 -C 4 )-alkoxy or trifluoromethoxy,

R 4 is (C 3 -C 7 )-cycloalkyl or is (C 1 -C 6 )-alkyl which may be substituted by (C 3 -C 7 )-cycloalkyl or once to three times by fluorine,

R 5 is hydrogen, halogen, cyano, nitro, trifluoromethyl, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy,

and

R 6 is hydrogen or fluorine,

or a salt, solvate, or solvate of a salt thereof.

2. The compound of the formula (I) as claimed in claim 1 , in which

R 1 and R 2 are identical or different and are methyl or trifluoromethyl,

R 3 is (C 5 -C 7 )-cycloalkyl, is (C 1 -C 6 )-alkyl which may be substituted by (C 3 -C 5 )-cycloalkyl or once to three times by fluorine, or is phenyl which may be substituted by fluorine, chlorine, trifluoromethyl, methyl, isopropyl, tert-butyl or methoxy,

R 4 is (C 3 -C 5 )-cycloalkyl or is (C 1 -C 4 )-alkyl which may be substituted by (C 3 -C 5 )-cycloalkyl or once to three times by fluorine,

R 5 is hydrogen, fluorine, chlorine, nitro or methyl,

and

R 6 is hydrogen or fluorine,

or a salt, solvate, or solvate of a salt thereof.

3. The compound of the formula (I) as claimed in claim 1 , in which

R 1 is methyl or trifluoromethyl,

R 2 is methyl,

R 3 is methyl, trifluoromethyl, isobutyl, isopentyl, cyclobutylmethyl, cyclopentylmethyl, 2-(cyclopropyl)ethyl, 2-(cyclobutyl)ethyl, 2-(cyclopentyl)ethyl or is phenyl which may be substituted in the para position by fluorine, trifluoromethyl, methyl or methoxy,

R 4 is methyl, ethyl, 2,2,2-trifluoroethyl, n-propyl, isopropyl, tert-butyl, cyclobutyl, cyclopentyl, cyclopropylmethyl or cyclobutylmethyl,

R 5 is hydrogen, fluorine or chlorine,

and

R 6 is hydrogen,

or a salt, solvate, or solvate of a salt thereof.

4. A process for preparing compounds of the formula (I) as defined in claim 1 , characterized in that a compound of the formula (II)

in which R 5 and R 6 each have the meanings in claim 1

either

[A] is reacted in a one-stage process (one-pot reaction) with a compound of the formula (III)

in which R 1 and R 3 each have the meanings in claim 1 ,

and a compound of the formula (IV)

in which R 2 and R 4 each have the meanings in claim 1 ,

or

[B] is reacted in a one-stage process (one-pot reaction) with a compound of the formula (V)

in which R 1 and R 3 each have the meanings in claim 1 ,

and a compound of the formula (VI)

in which R 2 and R 4 each have the meanings in claim 1 ,

or

[C] is converted in a two-stage process firstly with a compound of the formula (III) into a compound of the formula (VII)

in which R 1 , R 3 , R 5 and R 6 each have the meanings in claim 1 ,

and the latter is then reacted in a second step with a compound of the formula (IV),

or

[D] is converted in a two-stage process firstly with a compound of the formula (VI) into a compound of the formula (VIII)

in which R 2 , R 4 , R 5 and R 6 each have the meanings in claim 1 ,

and the latter is then reacted in a second step with a compound of the formula (V).

5. A pharmaceutical composition comprising a compound of the formula (I) as defined in claim 1 in combination with an inert, non-toxic, pharmaceutically suitable excipient.

6. A pharmaceutical composition comprising a compound of the formula (I) as defined in claim 1 in combination with a further active ingredient selected from the group consisting of ACE inhibitors, renin inhibitors, angiotensin II receptor antagonists, beta blockers, acetyl salicylic acid, diuretics, potassium supplements, calcium antagonists, statins, digitalis (digoxin) derivatives, calcium sensitizers, nitrates, anticoagulants, antiarrhythmics, vasodilators, and thrombolytics.