IP Library › Granted Patent US 8,119,140
Granted Patent B2
US 8,119,140 · App. 11/990,222 · Granted Feb 21, 2012

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

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Quick Facts
Patent No.
US 8,119,140
App. No.
11/990,222
Granted
Feb 21, 2012
Kind
B2
Abstract

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Claims (7)

1. An isolated mosaic clade M human immunodeficiency virus type 1 (HIV-1) Nef polypeptide comprising an amino acid sequence selected from the group consisting of Nef coreM 4.1 (SEQ ID NO:33), Nef coreM 4.2 (SEQ ID NO:34), Nef coreM 4.3 (SEQ ID NO:35), and Nef coreM 4.4 (SEQ ID NO:36).

2. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid sequence of Nef coreM 4.1 (SEQ ID NO:33).

3. A composition comprising at least one polypeptide according to claim 1 and a carrier.

4. A method of inducing an immune response in a mammal comprising administering to said mammal an amount of at least one polypeptide according to claim 1 sufficient to effect said induction.

5. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid sequence of Nef coreM 4.2 (SEQ ID NO:34).

6. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid sequence of Nef coreM 4.3 (SEQ ID NO:35).

7. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid sequence of Nef coreM 4.4 (SEQ ID NO:36).

Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018
From: LOS ALAMOS NATIONAL SECURITY, LLC
To: TRIAD NATIONAL SECURITY, LLC
Reel/Frame 047485/0173 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 2, 2009
From: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 023321/0258 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 22, 2009
From: KORBER, BETTE T.; PERKINS, SIMON; BHATTACHARYA, TANMOY; FISCHER, WILLIAM M.; THEILER, JAMES; YUSIM, KARINA; KUIKEN, CARLA
To: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE
Reel/Frame 023269/0148 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2009
From: LETVIN, NORMAN
To: BETH ISRAEL DEACONESS MEDICAL CENTER
Reel/Frame 022587/0952 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2009
From: HAYNES, BARTON F.
To: DUKE UNIVERSITY
Reel/Frame 022587/0907 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2009
From: HAHN, BEATRICE H.
To: THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION
Reel/Frame 022587/0875 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2009
From: KORBER, BETTE T.; PERKINS, SIMON; BHATTACHARYA, TANMOY; FISCHER, WILLIAM M.; THEILER, JAMES; YUSIM, KARINA; KUIKEN, CARLA
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 022587/0897 →