Carboxamide compounds and their use as calpain inhibitors

1. A carboxamide compound of the formula I-A′ or I-A′″,

in which

n is 0, 1 or 2,

m is 0, 1 or 2,

one of the variables Y 1 , Y 2 , Y 3 and Y 4 is a nitrogen atom, and the remaining variables Y 1 , Y 2 , Y 3 and Y 4 are CH,

R 1 is hydrogen, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -alkynyl, where the last 3 radicals mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 1a ,

 C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, where a cycloalkyl in the last two radicals mentioned may additionally have 1,2,3 or 4 identical or different R 1b radicals, may have a CH 2 group replaced by O, NH, or S, or may have two adjacent C atoms form a double bond,

 aryl, hetaryl, aryl-C 1 -C 6 -alkyl, aryl-C 2 -C 6 -alkenyl, hetaryl-C 1 -C 4 -alkyl or hetaryl-C 2 -C 6 -alkenyl, where aryl and hetaryl in the last 6 radicals mentioned may be unsubstituted or carry 1, 2, 3 or 4 identical or different radicals R 1c ; where

R 1a is selected independently of one another from OH, SH, COOH, CN, OCH 2 COOH, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 3 -C 7 -cycloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, COOR a1 ,CONR a2 R a3 , SO 2 NR a2 R a3 , —NR a2 —SO 2 —R a4 , NR a2 —CO—R a5 , SO 2 —R a4 , and NR a6 R a7 ,

R 1b is selected independently of one another from OH, SH, COOH, CN, OCH 2 COOH; halogen, phenyl which optionally has 1, 2 or 3 substituents R 1d , C 1 ,-C 6 -alkyl, C,-C 6 -alkoxy, C 1 -C 6 -alkylthio, where the alkyl moieties in the last 3 substituents mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 1a , COOR b1 , CONR b2 R b3 , SO 2 NR b2 R b3 , NR b2 —SO 2 —R b4 , NR b2 —CO—R b5 , SO 2 —R b4 , and NR b6 R b7 , where

 in addition two R 1b radicals may together form a C 1 -C 4 -alkylene group, or 2 R 1b radicals bonded to adjacent C atoms of cycloalkyl may form together with the carbon atoms to which they are bonded a benzene ring,

R 1c is selected independently of one another from OH, SH, halogen, NO 2 , NH 2 , CN, CF 3 , CHF 2 , CH 2 F, O—CF 3 , O—CHF 2 , O—CH 2 F, COOH, OCH 2 COOH, Cl-C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkylthio, where the alkyl moieties in the last 4 substituents mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 1a ,

 C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -cycloalkoxy, where the cycloalkyl moiety of the last three radicals mentioned may have 1, 2, 3 or 4 R 1b radicals,

 aryl, hetaryl, O-aryl, O—CH 2 -aryl, where the last three radicals mentioned are unsubstituted in the aryl moiety or may carry 1, 2, 3 or 4 R 1d radicals,

 COOR c1 , CONR c2 RO c3 , SO 2 NR c2 R c3 , NR c2 —SO 2 —R c4 , NR c2 —CO—R c5 , SO 2 —R c4 ,

 —(CH 2 ) p —NR c6 R c7 with p=0, 1, 2, 3, 4, 5 or 6 and

 O—(CH 2 ) q —NR c6 R c7 with q=2, 3, 4, 5 or 6; where

R a1 , R b1 and R c1 are independently of one another H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R 1a , or C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d ,

R a2 , R b2 and R c2 are independently of one another H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C,-C 6 -alkyl which has 1, 2 or 3 substituents R 1a , or C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d , and

R a3 , R b3 and R c3 are independently of one another H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R 1a , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d , or the two radicals R a2 and R a3 , or R b2 and R b3 or R c2 and R c3 form together with the N atom a 3 to 7-membered, optionally substituted nitrogen heterocycle which may optionally have 1, 2 or 3 further different or identical heteroatoms from the group of O, N, S as ring members,

R a4 , R b4 and R c4 are independently of one another C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R 1a , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d , and

R a5 , R b5 and R c5 have independently of one another one of the meanings mentioned for R a1 , R b1 , and R c1 ;

R a6 , R b6 and R c6 are independently of one another H, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R 1a , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, CO—C 1 -C 6 -alkyl, CO—O—C,-C 6 -alkyl, SO 2 —C 1 -C 6 -alkyl, aryl, hetaryl, O-aryl, OCH 2 -aryl, aryl-C 1 -Ca-alkyl, hetaryl-C 1 -C 4 -alkyl, CO-aryl, CO-hetaryl, CO-(aryl-C 1 -C 4 -alkyl), CO-(hetaryl-C 1 -C 4 -alkyl), CO—O-aryl, CO—O-hetaryl, CO—O-(aryl-C 1 -C 4 -alkyl), CO—O-(hetaryl-C 1 -C 4 -alkyl), SO 2 -aryl, SO 2 -hetaryl, SO 2 -(aryl-C 1 -C 4 -alkyl) or SO 2 -(hetaryl-C 1 -C 4 -alkyl), where aryl and hetaryl in the last 18 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d , and

R a7 , R b7 and R c7 are independently of one another H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R 1a , or C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -hetercycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R 1d , or the two radicals R a6 and R a7 , or R b6 and R b7 or R c6 and R c7 form together with the N atom a 3 to 7-membered, optionally substituted nitrogen heterocycle which may optionally have 1, 2 or 3 further different or identical heteroatoms from the group of O, N and S as ring members, or two radicals R 1b and R 1c bonded to adjacent C atoms form together with the C atoms to which they are bonded a 4, 5, 6 or 7-membered, optionally substituted carbocycle or an optionally substituted heterocycle which has 1, 2 or 3 different or identical heteroatoms from the group of O, N and S as ring members;

R 1d is selected from halogen, OH, SH, NO 2 , COOH, C(O)NH 2 , CHO, CN, NH 2 , OCH 2 COOH, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, CO—C 1 -C 6 -alkyl, CO—O—C 1 -C 6 -alkyl, NH—C 1 -C 6 -alkyl, NHCHO, NH—C(O)C 1 -C 6 -alkyl, and SO 2 —C 1 -C 6 -alkyl;

R 2 is hydrogen, C 1 -C 10 -alkyl, C 1 -C 10 -alkoxy, C 2 -C 10 -alkenyl, C 2 -C-alkynyl, where the last 4 radicals mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 2a , C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, where cycloalkyl in the last two radicals mentioned may additionally have 1,2,3, or 4 identical or different R 2b radicals, may have a CH 2 group replaced by O, NH, or S, or may have two adjacent C atoms form a double bond, aryl, O-aryl, O—CH 2 -aryl, hetaryl, aryl-C 1 -C 6 -alkyl, aryl-C 2 -C 6 -alkenyl, hetaryl-C 1 -C 4 -alkyl or hetaryl-C 2 -C 6 -alkenyl, where aryl and hetaryl in the last 8 radicals mentioned may be unsubstituted or carry 1, 2, 3 or 4 identical or different R 2c radicals; where

 R 2a has one of the meanings indicated for R 1a ,

 R 2b has one of the meanings indicated for R 1b , and

 R 2c has one of the meanings indicated for R 1c ;

R 3a and R 3b are independently of one another hydroxy or C 1 -C 4 -alkoxy, or together with the carbon atom to which they are bonded are C═O; or

R 3a and R 3b together form a group O-Alk-O, S-Alk-O or S-Alk-S, where Alk is linear C 2 -C 5 -alkanediyl, which may be unsubstituted or substituted with 1, 2, 3 or 4 radicals selected from C 1 -C 4 -alkyl and halogen; or

R 3a and R 3b together with the carbon atom to which they are bonded form a group C═NR 3 , where R 3 is selected from H, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyl, C 2 -C 6 -alkenyloxy, C 3 -C 6 -cycloalkoxy and C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyloxy;

X is hydrogen or a radical of the formulae C(═O)—O—R x1 , C(═O)—NR x2 R x3 , C(═O)—N(R x4 )—(C 1 -C 6 -alkylene)-NR x2 R x3 or C(═O)—N(R x4 )NR x2 R x3 , in which

R x1 is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , or C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, where alkyl, alkenyl, alkoxy, alkynyl, cycloalkyl, heterocycloalkyl in the last 6 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xa , aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xd,

R x2 is H, OH, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl -C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, CO—C 1 -C 6 -alkyl, CO—O—C 1 -C 6 -alkyl, SO 2 —Ci-C 6 -alkyl, O—C 1 -C 6 -alkyl, where alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl in the last 10 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xa , aryl, O-aryl, O—CH 2 -aryl, hetaryl, O—CH 2 -hetaryl, aryl-C 1 -C 4 -alkyl, hetaryl-C 1 -C 4 -alkyl, CO-aryl, CO-hetaryl, CO-(aryl-C 1 -C 4 -alkyl), CO-(hetaryl-C 1 -C 4 -alkyl), CO—O-aryl, CO—O-hetaryl, CO—O-(aryl-C 1 -C 4 -alkyl), CO—O-(hetaryl-C 1 -C 4 -alkyl), SO 2 -aryl, SO 2 -hetaryl, SO 2 -(aryl-C 1 -C 4 -alkyl) or SO 2 -(hetaryl-C 1 -C 4 -alkyl), where aryl and hetaryl in the last 19 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xd , and

R x3 is H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 1 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -Ca-alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, where alkyl, alkenyl, alkoxy, alkynyl, cycloalkyl, heterocycloalkyl in the last 6 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xa , aryl, aryl-C 1 -C 4 -alkyl, hetaryl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xd , or the two radicals R 4 and R x3 form together with the N atom a 3 to 7-membered nitrogen heterocycle which may optionally have 1, 2 or 3 further different or identical heteroatoms from the group of O, N and S as ring members, and which may have 1, 2 or 3 substituents R xb ,

R x4 is H, OH, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , or C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -Ca-alkyl, CO—C 1 -C 6 -alkyl, CO—O—C 1 -C 6 -alkyl, SO 2 —C 1 -C 6 -alkyl, where alkyl, alkenyl, alkoxy, alkynyl, cycloalkyl, heterocycloalkyl in the last 9 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xa , aryl, O-aryl, O—CH 2 -aryl, hetaryl, aryl-C 1 -C 4 -alkyl, hetaryl-C 1 -C 4 -alkyl, CO-aryl, CO-hetaryl, CO-(aryl-C 1 -C 4 -alkyl), CO-(hetaryl-C 1 -C 4 -alkyl), CO—O-aryl, CO—O-hetaryl, CO—O-(aryl-C 1 -C 4 -alkyl), CO—O-(hetaryl-C 1 -C 4 -alkyl), SO 2 -aryl, SO 2 -hetaryl, SO 2 -(aryl-C 1 -C 4 -alkyl) or SO 2 -(hetaryl-C 1 -C 4 -alkyl), where aryl and hetaryl in the last 18 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xd , and

where R xa has one of the meanings indicated for R 1a , R xb has one of the meanings indicated for R 1b , and R xd has one of the meanings indicated for R 1d ;

R y is selected independently of one another from OH, SH, halogen, NO 2 , NH 2 , CN, CF 3 , CHF 2 , CH 2 F, O—CF 3 , O—CHF 2 , O—CH 2 F, COOH, OCH 2 COOH, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkylthio, where the last 4 radicals mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R ya , C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -cycloalkyl-O, where the cycloalkyl moiety in the last three radicals mentioned may have 1, 2, 3 or 4 R yb radicals, aryl, O-aryl, CH 2 -aryl, O—CH 2 -aryl, where the last 4 radicals mentioned are unsubstituted in the aryl moiety or may carry 1, 2, 3 or 4 radicals R yd ,

 COOR y1 , CONR y2 R y3 , SO 2 NR y2 R y3 , —NH—SO 2 —R y4 ,

 NH—CO—R y5 , SO 2 —R y4 ,

 —(CH 2 ) p —NR y6 R y7 with p=0, 1, 2, 3, 4, 5 or 6 and

 O—(CH 2 ) q —NR y6 R y7 with q=2, 3, 4, 5 or 6;

 or two R y radicals bonded to adjacent C atoms form together with the C atoms to which they are bonded a 4, 5, 6 or 7-membered, optionally substituted carbocycle or heterocycle which has 1, 2 or 3 different or identical heteroatoms from the group of O, N, S as ring members, where

 R ya has one of the meanings indicated for R 1a ,

 R yb has one of the meanings indicated for R 1b ,

 R yd has one of the meanings indicated for R 1d ,

 R y1 has one of the meanings indicated for R c1 ,

 R y2 has one of the meanings indicated for R c2 ,

 R y3 has one of the meanings indicated for R c3 ,

 R y4 has one of the meanings indicated for R c4 ,

 R y5 has one of the meanings indicated for R c5 ,

 R y6 has one of the meanings indicated for R c6 , and

 R y7 has one of the meanings indicated for R c7 ;

R w is selected from OH, SH, halogen, NO 2 , NH 2 , CN, CF 3 , CHF 2 , CH 2 F, O—CF 3 , O—CHF 2 , O—CH 2 F, COOH, OCH 2 COOH, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkylthio, where the last 4 radicals mentioned may be partly or completely halogenated and/or have 1, 2 or 3 substituents R wa , C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -cycloalkoxy, where the cycloalkyl moiety of the last three radicals mentioned may have 1, 2, 3 or 4 radicals R wb , aryl, O-aryl, O—CH 2 -aryl, hetaryl, where the last four radicals mentioned are unsubstituted in the aryl moiety or may carry 1, 2, 3 or 4 radicals R wd ,

 COOR w1 , CONR w2 R w3 , SO 2 NR w2 R w3 , NR w2 —SO 2 —R w4 ,

 NR w2 —CO—R w5 , SO 2 —R w4 ,

 —(CH 2 ) p —NR w6 R w7 with p=0, 1, 2, 3, 4, 5 or 6 and

 O—(CH 2 ) q —NR w6 R w7 with q=2, 3, 4, 5 or 6;

 or two R w radicals bonded to adjacent C atoms form together with the C atoms to which they are bonded a 4, 5, 6 or 7-membered, optionally substituted carbocycle or an optionally substituted heterocycle which has 1, 2 or 3 different or identical heteroatoms from the group of O, N, S as ring members, where

 R wa has one of the meanings indicated for R 1a ,

 R wb has one of the meanings indicated for R 1b ,

 R wd has one of the meanings indicated for R 1d ,

 R w1 has one of the meanings indicated for R c1 ,

 R w2 has one of the meanings indicated for R c2 ,

 R w3 has one of the meanings indicated for R c3 ,

 R w4 has one of the meanings indicated for R c4 ,

 R w5 has one of the meanings indicated for R c5 ,

 R w6 has one of the meanings indicated for R c6 ,

 R w7 has one of the meanings indicated for R c7 ,

where aryl means a mono-, bi- or tricyclic aromatic hydrocarbon radical;

or a tautomer thereof or a pharmaceutically suitable salt thereof.

2. The carboxamide compound as claimed in claim 1 , in which m is 0 or 1 and, when m=1, R w is selected from OH, F, Cl, CN, CF 3 , C 1 -C 6 -alkyl which is unsubstituted or may have 1, 2 or 3 substituents R wa , or C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy and C 3 -C 7 -cycloalkyl.

3. The carboxamide compound as claimed in claim 1 , in which X is a C(═O)—NR x2 R x3 radical.

4. The carboxamide compound as claimed in claim 3 , in which R x2 is H, OH, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 7 -heterocycloalkyl-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, aryl, hetaryl, aryl-C 1 -C 4 -alkyl or hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 4 radicals mentioned are unsubstituted or have 1, 2 or 3 substituents R xd , and

R x3 is H, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkyl which has 1, 2 or 3 substituents R xa , or

NR x2 R x3 is:

in which R x5 is hydrogen or has the meaning indicated in claim 1 for R xb .

5. The carboxamide compound as claimed in claim 4 , in which X is C(O)—NH 2 .

6. The carboxamide compound as claimed in claim 1 , in which R 1 is selected from C 1 -C 10 -alkyl which may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 1a , C 3 -C 7 -cycloalkyl-C 1 -C 4 -alkyl, where the cycloalkyl moiety may have 1, 2, 3 or 4 radicals R 1b , phenyl-C 1 -C 4 -alkyl and hetaryl-C 1 -C 4 -alkyl, where phenyl and hetaryl in the last 2 radicals mentioned may be unsubstituted or carry 1, 2, 3 or 4 identical or different radicals R 1c .

7. The carboxamide compound as claimed in claim 1 , in which R 2 is different from hydrogen.

8. The carboxamide compound as claimed in claim 7 , in which R 2 is selected from:

C 1 -C 10 -alkyl which may be partly or completely halogenated and/or have 1, 2 or 3 substituents R 2a , aryl, hetaryl, aryl-C 1 -C 6 -alkyl, aryl-C 2 -C 6 -alkenyl and hetaryl-C 1 -C 4 -alkyl, where aryl and hetaryl in the last 5 radicals mentioned may be unsubstituted or carry 1, 2, 3 or 4 identical or different radicals R 2c .

9. The carboxamide compound as claimed in claim 8 , in which R 2 is selected from aryl and hetaryl, where aryl and hetaryl may be unsubstituted or carry 1, 2, 3 or 4 identical or different radicals R 2c .

10. The carboxamide compound as claimed in claim 1 , in which R y is selected from OH, F, Cl, NH 2 , CN, CF 3 , —CHF 2 , O—CF 3 , O—CHF 2 , O—CH 2 F, C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, pyrrolidinyl, piperidinyl, morpholinyl, imidazolyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, CONR y2 R y3 , SO 2 NR y2 R y3 , —NH—SO 2 —R y4 , —(CH 2 ) p —NR y6 R y7 , NH—CO—R y5 , in which p is 1, 2, 3, 4, or 5, and R y2 , R y3 , R y4 , R y5 , R y6 , R y7 are H or C 1 -C 6 -alkyl, phenyl, benzyl and O-benzyl, where the phenyl ring in the last 3 groups mentioned may have 1, 2 or 3 substituents selected from halogen, OH, SH, NO 2 , COOH, C(O)NH 2 , CHO, CN, NH 2 , OCH 2 COOH, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, CO—C 1 -C 6 -alkyl, CO—O—C 1 -C 6 -alkyl, NH—C 1 -C 6 -alkyl, NHCHO, NH—C(O)C 1 -C 6 -alkyl, and SO 2 —C 1 -C 6 -alkyl.

11. The carboxamide compound as claimed in claim 1 , which corresponds to the formulae I-A.a′

in which m, R 1 , R 3a , R 3b , R 2 , R y , and R w have the aforementioned meanings, n is 0, 1 or 2, or a tautomer thereof or a pharmaceutically suitable salt thereof.

12. The carboxamide compound as claimed in claim 1 , which has the S configuration at the carbon atom carrying the group R 1 .

13. A pharmaceutical composition comprising at least one carboxamide compound as claimed in claim 1 , or a tautomer or pharmaceutically suitable salt thereof and a pharmaceutically acceptable carrier.