IP Library Granted Patent US 8,470,985
Granted Patent B2
US 8,470,985 · App. 11/990,833 · Granted Jun 25, 2013

Triazole compounds and methods of making and using the same

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,470,985
App. No.
11/990,833
Granted
Jun 25, 2013
Kind
B2
Abstract

The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory, and prokinetic agents. These compounds are represented by the following formula (I): wherein R 1 , R 2 , ect. Are defined in claim 1 .

Claims (134)

1. A compound having the structure selected from:

Com-

pound

Structure

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

201

202

203

204

205

206

207

210

211

212

213

221

222

223

224

225

226

230

231

232

233

234

235

236

237

238

239

240

241

242

243

and a pharmaceutically acceptable salt, ester, or N-oxide thereof.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2019
From: MELINTA THERAPEUTICS, INC.; MELINTA SUBSIDIARY CORP.
To: BIOVERSYS AG
Reel/Frame 050128/0253 →
RELEASE OF SECURITY INTEREST Recorded Apr 11, 2019
From: CORTLAND CAPITAL MARKET SERVICES LLC, AS AGENT
To: MELINTA THERAPEUTICS, INC.
Reel/Frame 048875/0750 →
SECURITY INTEREST Recorded Jan 8, 2018
From: MELINTA THERAPEUTICS, INC.; REMPEX PHARMACEUTICALS, INC.; CEMPRA PHARMACEUTICALS, INC.; CEM-102 PHARMACEUTICALS, INC.
To: CORTLAND CAPITAL MARKET SERVICES LLC, AS AGENT
Reel/Frame 045019/0552 →
CHANGE OF NAME Recorded Jan 13, 2014
From: RIB-X PHARMACEUTICALS, INC.
To: MELINTA THERAPEUTICS, INC.
Reel/Frame 031997/0731 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2009
From: BHATTACHARJEE, ASHOKE; KANYO, ZOLTAN F.
To: RIB-X PHARMACEUTICALS, INC.
Reel/Frame 023239/0779 →