IP Library › Granted Patent US 8,080,632
Granted Patent B2
US 8,080,632 · App. 11/991,121 · Granted Dec 20, 2011

Peptide mimics of melanocyte stimulating hormone

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Quick Facts
Patent No.
US 8,080,632
App. No.
11/991,121
Granted
Dec 20, 2011
Kind
B2
Abstract

Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammalian cells are provided, as are methods for treating a mammal suffering from, or at risk for, a condition mediated by an inflammatory cytokine cascade. Further provided are methods of reducing levels of an inflammatory cytokine in a mammal, methods of treating an overweight mammal, methods of decreasing food intake in a mammal and methods of inhibiting innate immunity in the digestive system of a mammal.

Claims (7)

1. An isolated and purified peptide of less than 100 amino acids having melanocyte stimulating hormone (MSH) activity, wherein the peptide comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:16, or SEQ ID NO:17.

2. The peptide of claim 1 , wherein the peptide comprises the amino acid sequence of any one of SEQ ID NO: 1 , SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:16, or SEQ ID NO:17.

3. The peptide of claim 1 , wherein the peptide comprises the amino acid sequence of SEQ ID NO: 1.

4. The peptide of claim 1 , wherein the peptide consists of the amino acid sequence of any one of SEQ ID NO: 1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:15, SEQ ID NO:16, or SEQ ID NO:17.

5. The peptide of claim 1 , consisting of the amino acid sequence of SEQ ID NO: 1.

6. An isolated and purified peptide of 33 amino acids or less, wherein the peptide comprises an amino acid sequence of SEQ ID NO:2, wherein the peptide has melanocyte stimulating hormone (MSH) activity.

7. The peptide of claim 6 , comprising an amino acid sequence of SEQ ID NO:18.

Assignments (1)
CHANGE OF NAME Recorded Aug 21, 2019
From: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
To: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Reel/Frame 050114/0931 →