Compositions and methods for diagnosing and treating an inflammation
View Patent ↗An isolated polypeptide is provided. The polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein the antigen recognition domain comprises at least three CDR amino acid sequences selected from the group consisting of SEQ ID NO: 11, 15, 19, 23, 27 and 31. Also provided are compositions which comprise the peptide and uses of same.
1. An isolated polypeptide comprising an antigen recognition domain capable of specifically binding a human scavenger receptor, wherein said antigen recognition domain comprises CDR amino acid sequences as set forth in SEQ ID NO: NO: 11, 15, 19, 23, 27 and 31.
2. An isolated polynucleotide comprising a nucleic acid sequence encoding the polypeptide of claim 1 .
3. A pharmaceutical composition comprising as an active ingredient the polypeptide of claim 1 .
4. A method of treating Crohn's disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the polypeptide of claim 1 , thereby treating the Crohn's disease in the subject.