2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
View Patent ↗The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.
1. A substantially optically pure 4-substituted-pyrrolidin-2-one of formula (III),
wherein R 1 is ethyl, n-propyl, a C 1-3 alkyl substituted by one or more halogens, or a C 2-4 alkenyl substituted by one or more halogens, and wherein 1* designates the stereogenic carbon of the pyrrolidin-2-one ring.
2. The 4-substituted-pyrrolidin-2-one of claim 1 wherein R 1 is n-propyl.
3. The 4-substituted-pyrrolidin-2-one of claim 1 wherein R 1 is 2,2-difluorovinyl.
4. A substantially optically pure compound of formula (IIIa)
5. A substantially optically pure compound of formula (IIIb)