Imidazole based LXR modulators
View Patent ↗Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R 1 , R 2 , R 21 , R 3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
1. A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein
R 1 is -L 1 -R 5 , wherein
L 1 is a bond; and
R 5 is aryl optionally substituted with one or more R 5a ; wherein
each R 5a is independently halogen, nitro, heteroaryl, heterocyclyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC 1-6 alkoxy, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, SO 2 R 11 , OR 11 , SR 11 , N 3 , SO 2 R 11 , COR 11 , SO 2 N(R 11 ) 2 , SO 2 NR 11 COR 11 , C≡N, C(O)OR 11 , CON(R 11 ) 2 , CON(R 11 )OR 11 , OCON(R 11 ) 2 , NR 11 COR 11 , NR 11 CON(R 11 ) 2 , NR 11 COOR 11 , or N(R 11 ) 2 , wherein
each R 5a is optionally substituted with one or more groups which independently are -halogen, —C 1 -C 6 alkyl, aryloxy C 0-6 alkylSO 2 R 11 , C 0-6 alkylCOOR 11 , C 0-6 alkoxyaryl, C 1 -C 6 haloalkyl, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —SO 2 R 11 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , or —N(R 11 ) 2 ;
R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;
R 2 is —H, —[C(R 15 ) 2 ] m —OH, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, halogen, —C(O)N(R 11 ) 2 , or —COOR 11 ;
provided that R 2 and R 21 are not simultaneously hydrogen;
J is aryl or heteroaryl;
K is aryl or heteroaryl;
each R 4 and R 41 is independently halogen, oxo, nitro, CR 11 ═CR 11 COOR 11 , aryloxy, aralkyloxy, aryloxyalkyl, arylC 0 -C 6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G 1 , -E-G 1 ′ or -D-E-G 1 , wherein
D is —O—;
E is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCOOR 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , —SOR 11 , or —SR 11 ;
wherein each R 4 is optionally substituted with one or more R 4a ,
wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, arylC 0 -C 6 alkylcarboxy, -G′, -E′-G′, or -D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-; and
G′ is —H, -halogen, —COR 11 , —COOR 11 , —COOR 11 , —C≡N, —OR 11 , —NR 11 SO 2 R 11 , —SO 2 R 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ;
L 2 is a bond;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 0, 1, 2, 3, 4, or 5, provided that q is 0 if and only if K is not phenyl; and
q′ is 0, 1, 2, 3, or 4,
each R 10 is independently —R 11 , —C(≡O)R 11 , —CO 2 R 11 , or —SO 2 R 11 ;
each R 11 is independently -hydrogen, —C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —C 1 -C 6 haloalkyl, —N(R 12 ) 2 , aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,
wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;
each R 12 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0-6 alkoxyaryl, arylC 0-6 alkylcarboxy, —C 0 -C 6 alkylN(R 13 ) 2 , —NR 13 SO 2 R 13 , or —OC 0-6 alkylCOOR 13 ;
each R 13 is independently hydrogen, C 1- C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;
and each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 1 -C 6 )haloalkyl.
2. The compound according to claim 1 , wherein at least one of J and K is phenyl.
3. The compound according to claim 2 , of the formula,
or a pharmaceutically acceptable salt thereof.
4. The compound according to claim 3 , of the formula,
or a pharmaceutically acceptable salt thereof, wherein R 21 is —H, -halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.
5. The compound according to claim 3 wherein
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
6. The compound according to claim 3 , wherein
each R 41 is independently halogen, -G 2 , or -E-G 2 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 2 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, or halogen; and
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
7. The compound according to claim 4 , wherein each R 5a is independently halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, OR 11 , SO 2 R 11 , COR 11 , SO 2 N(R 11 ) 2 , C≡N, C(O)OR 11 , CON(R 11 ) 2 , NR 11 COR 11 , or N(R 11 ) 2 .
8. A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein,
L 1 is —[C(R 15 ) 2 ] m′ — or —C 3 -C 8 cycloalkyl; wherein m′ is any of 1 to 3; and
each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )haloalkyl;
R 5 is aryl, heterocyclyl, heteroaryl, —(C 3 -C 6 )cycloalkyl, —C, or —B—C, wherein
B is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-; and
C is halogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —SO 2 R 11 , —SR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , or —N(R 11 ) 2 ,
wherein R 5 is optionally substituted with one or more R 5a , wherein
each R 5a is independently halogen, nitro, heteroaryl, heterocyclyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC 1-6 alkoxy, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, SO 2 R 11 , OR 11 , SR 11 , N 3 , SO 2 R 11 , COR 11 , SO 2 N(R 11 ) 2 , SO 2 NR 11 COR 11 , C≡N, C(O)OR 11 , CON(R 11 ) 2 , CON(R 11 )OR 11 , OCON(R 11 ) 2 , NR 11 COR 11 , NR 11 CON(R 11 ) 2 , NR 11 COOR 11 , or N(R 11 ) 2 , wherein
each R 5a is optionally substituted with one or more groups which independently are -halogen, —C 1 -C 6 alkyl, aryloxy C 0-6 alkylSO 2 R 11 , C 0-6 alkylCOOR 11 , C 0-6 alkoxyaryl, C 1 -C 6 haloalkyl, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —SO 2 R 11 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , or —N(R 11 ) 2 ;
R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;
R 2 is —H, —[C(R 15 ) 2 ] m —OH, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, halogen, —C(O)N(R 11 ) 2 , or —COOR 11 ;
provided that R 2 and R 21 are not simultaneously hydrogen;
J and K are both phenyl;
each R 4 and R 41 is independently halogen, oxo, nitro, CR 11 ═CR 11 COOR 11 , aryloxy, aralkyloxy, aryloxyalkyl, arylC 0 -C 6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G 1 , -E-G 1 ′ or -D-E-G 1 , wherein
D is —O—;
E is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCOOR 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , —SOR 11 , or —SR 11 ;
wherein each R 4 is optionally substituted with one or more R 4a ,
wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, arylC 0 -C 6 alkylcarboxy, -G′, -E′-G′, or -D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-; and
G′ is —H, -halogen, —COR 11 , —COOR 11 , —C≡N, OR 11 , —NR 11 SO 2 R 11 , —SO 2 R 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ;
L 2 is a bond or —[C(R 15 ) 2 ] m —V 2 —[C(R 15 ) 2 ] n —, wherein
V 2 is independently —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C(R 11 ) 2 O—, —C(R 11 ) 2 NR 11 —, —C≡C—, —O—, —S—, —SO 2 —, —N(R 10 )CO—, —N(R 10 )CO 2 —, —CON(R 10 )—, —CON(R 11 )—, —CON(R 11 )O—, —CO—, —CS—, —CO 2 —, —OC(═O)—, —OC(═O)N(R 10 )—, —N(R 10 )SO 2 —, —SO 2 N(R 10 )—, —NR 10 CONR 10 —, —NR 10 CSNR 10 —, C 3 -C 6 cycloalkyl-, or C 3 -C 6 cyclohaloalkyl, or V 2 is C 2-6 alidiyl,
wherein alidiyl chain is optionally interrupted by —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C(R 11 ) 2 O—, —C(R 11 ) 2 NR 11 —, —C(R 11 ) 2 NR 11 —, —C≡C—, —O—, —S—, —N(R 10 )CO—, —N(R 10 )CO 2 —, —CON(R 10 )—, —CON(R 11 )—, —CON(R 11 )O—, —CO—, —CO 2 —, —OC(═O)—, —OC(═O)N(R 10 )—, —SO 2 —, —N(R 10 )SO 2 — or —SO 2 N(R 10 )—;
or V 2 is aryl, heteroaryl, or heterocyclyl, each of which is optionally substituted with one or more R 9 , wherein
each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 1, 2, 3, 4, or 5,
q′ is 0, 1, 2, 3, or 4,
each R 10 is independently —R 11 , —C(═O)R 11 , —CO 2 R 11 , or —SO 2 R 11 ;
each R 11 is independently -hydrogen, —C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —C 1 -C 6 haloalkyl, —N(R 12 ) 2 , aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,
wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;
each R 12 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0-6 alkoxyaryl, arylC 0-6 alkylcarboxy, —C 0 -C 6 alkylN(R 13 ) 2 , —NR 13 SO 2 R 13 , or —OC 0-6 alkylCOOR 13 ; and
each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl.
9. The compound according to claim 8 , wherein L 2 is a bond.
10. The compound according to claim 9 , of the formula,
or a pharmaceutically acceptable salt thereof.
11. The compound according to claim 10 , wherein
each R 15 is independently —H or —(C 1 -C 2 )alkyl;
m′ is 1 or 2; and
R 5 is phenyl optionally substituted with one or more R 5a .
12. The compound according to claim 11 , wherein
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
13. The compound according to claim 11 , wherein
each R 41 is independently halogen, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl or —C 1 -C 6 haloalkyl.
14. The compound according to claim 10 , wherein
R 15 is —H;
m is 1, 2, or 3; and
R 5 is heterocyclyl optionally substituted with one or more R 5a .
15. The compound according to claim 14 , wherein
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
16. The compound according to claim 14 , wherein
each R 41 is independently halogen, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl or —C 1 -C 6 haloalkyl.
17. A compound according to one of the following formulas,
or a pharmaceutically acceptable salt thereof, wherein,
R 1 is -L 1 -R 5 , wherein
L 1 is a bond, —[C(R 15 ) 2 ] m —, or —C 3 -C 8 cycloalkyl-; and
R 5 is phenyl or pyridyl, each optionally substituted with one or two R 5a , wherein
each R 5a is independently -halogen, —C 1 -C 6 alkoxy, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl;
R 2 , R 21 , and R 3 are each independently —H, —[C(R 15 ) 2 ] m —OH, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, halogen, —C(O)N(R 11 ) 2 , or —COOR 11 ;
provided that R 2 and R 21 are not simultaneously hydrogen;
G is a group of the formula,
wherein
L 2 is a bond;
J is phenyl, pyridyl, or thienyl;
K is phenyl or pyridyl;
q is 0, 1, 2, 3, 4, or 5, provided that q is 0 if and only if K is not phenyl;
q′ is 0, 1, 2, 3, or 4,
each R 41 is -halogen, —C 1 -C 6 alkyl, or C 1 -C 6 -haloalkyl; and
each R 4 is -halogen, —[C(R 15 ) 2 ] m —OH, —SO 2 R 11 , —SO 2 N(R 11 ) 2 , —C(O)N(R 11 ) 2 , —COOR 11 , —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl;
each m is 0, 1, 2, 3, 4, 5, or 6;
each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 1 -C 6 )haloalkyl; and
each R 11 is independently -hydrogen, —C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —C 1 -C 6 haloalkyl, —N(R 12 ) 2 , heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl, wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;
each R 12 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0-6 alkoxyaryl, arylC 0-6 alkylcarboxy, -C 0 -C 6 alkylN(R 13 ) 2 , —NR 13 SO 2 R 13 , or —OC 0-6 alkylCOOR 13 ; and
each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-.
18. The compound according to claim 10 , wherein
each R 15 is independently —H or —(C 1 -C 2 )alkyl;
m′ is 1 or 2; and
R 5 is heteroaryl optionally substituted with one or more R 5a .
19. The compound according to claim 18 , wherein
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein
each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
20. The compound according to claim 18 , wherein
each R 41 is independently halogen, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —,
wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl or —C 1 -C 6 haloalkyl.
21. A compound according to the formula,
or a pharmaceutically acceptable salt thereof, wherein
L 1 is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl; wherein m' is 1 or 2; and
R 5 is heteroaryl optionally substituted with one or more R 5a , wherein
each R 5a is independently halogen, nitro, heteroaryl, heterocyclyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC 1-6 alkoxy, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, SO 2 R 11 , OR 11 , SR 11 , N 3 , SO 2 R 11 , COR 11 , SO 2 N(R 11 ) 2 , SO 2 NR 11 COR 11 , C≡N, C(O)OR 11 , CON(R 11 ) 2 , CON(R 11 )OR 11 , OCON(R 11 ) 2 , NR 11 COR 11 , NR 11 CON(R 11 ) 2 , NR 11 COOR 11 , or N(R 11 ) 2 , wherein
each R 5a is optionally substituted with one or more groups which independently are -halogen, —C 1 -C 6 alkyl, aryloxy C 0-6 alkylSO 2 R 11 , C 0-6 alkylCOOR 11 , C 0-6 alkoxyaryl, C 1 -C 6 haloalkyl, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —SO 2 R 11 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , or —N(R 11 ) 2 ;
R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;
R 2 is —H, —[C(R 15 ) 2 ] m —OH, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, halogen, —C(O)N(R 11 ) 2 , or —COOR 11 ;
provided that R 2 and R 21 are not simultaneously hydrogen;
each m is 0, 1, 2, 3, 4, 5, or 6;
q is 1, 2, 3, 4, or 5,
q′ is 0, 1, 2, 3, or 4, and
each R 4 and R 41 is independently halogen, oxo, nitro, CR 11 ═CR 11 COOR 11 , aryloxy, aralkyloxy, aryloxyalkyl, arylC 0 -C 6 alkylcarboxy, aryl, heteroaryl, heterocyclyl, heteroaryloxy, heterocyclyloxy, -G 1 , -E-G 1 ′ or -D-E-G 1 , wherein
D is —O—;
E is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCOOR 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , —SOR 11 , or —SR 11 ;
wherein each R 4 is optionally substituted with one or more R 4a ,
wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, arylC 0 -C 6 alkylcarboxy, -G′, -E′-G′, or-D′-E′-G′, wherein
D′ is —O—;
E′ is —[C(R 15 ) 2 ] M — or —C 3 -C 8 cycloalkyl-; and
G′ is —H, -halogen, —COR 11 , —COOR 11 , —C≡N, OR 11 , —NR 11 SO 2 R 11 , —SO 2 R 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ;
each R 11 is independently -hydrogen, —C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, -C 1 -C 6 haloalkyl, —N(R 12 ) 2 , aryl, -(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,
wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;
each R 12 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0-6 alkoxyaryl, arylC 0-6 alkylcarboxy, —C 0 -C 6 alkylN(R 13 ) 2 , —NR 13 SO 2 R 13 , or —OC 0-6 alkylCOOR 13 ;
each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;
and each R 15 is independently H, halogen, or (C 1 -C 6 )alkyl.
22. The compound according to claim 21 , wherein
each R 4 is independently halogen, aryl, heteroaryl, heterocyclyl, -G 1 , or -E-G 1 , wherein
E is —[C(R 15 ) 2 ] m —, wherein each R 15 is independently hydrogen or halogen; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , or —SO 2 R 11 .
23. A compound according to one of the following formulas,
or a pharmaceutically acceptable salt thereof, wherein,
R 1 is -L 1 -R 5 , wherein
L 1 is a bond, —C 3 -C 8 cycloalkyl- or L 5 , wherein
each L 5 is independently —[C(R 15 ) 2 ] m —, wherein
m is 0, 1, 2, or 3; and
each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )haloalkyl; and
R 5 is aryl, heterocyclyl, heteroaryl, —C, or -B-C, wherein
B is —[C(R 15 ) 2 ] m —, —C 3 -C 6 cycloalkyl-; and
C is —C 1 -C 6 alkyl or —C 1 -C 6 haloalkyl;
wherein R 5 is optionally substituted with one or more R 5a , wherein
each R 5a is independently halogen, nitro, heteroaryl, heterocyclyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, aryl, arylalkyl, aryloxy, aryloxyaryl, arylC 1-6 alkoxy, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, SO 2 R 11 , OR 11 , SR 11 , N 3 , SO 2 R 11 , COR 11 , SO 2 N(R 11 ) 2 , SO 2 NR 11 COR 11 , C≡N, C(O)OR 11 , CON(R 11 ) 2 , CON(R 11 )OR 11 , OCON(R 11 ) 2 , NR 11 COR 11 , NR 11 CON(R 11 ) 2 , NR 11 COOR 11 , or N(R 11 ) 2 , wherein
each R 5a is optionally substituted with one or more groups which independently are -halogen, —C 1 -C 6 alkyl, aryloxy, C 0-6 alkylSO 2 R 11 , C 0-6 alkylCOOR 11 , C 0-6 alkoxyaryl, —C 1 -C 6 haloalkyl, —SO 2 R 11 , OR 11 , —SR 11 , —N 3 , —SO 2 R 11 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)O R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , or —N(R 11 ) 2 ;
R 2 is —H, —[C(R 15 ) 2 ] m —OH, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, halogen, —C(O)N(R 11 ) 2 , or —COOR 11 ;
R 21 is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl; and
provided that R 2 and R 21 are not simultaneously hydrogen;
G is a group of the formula,
wherein
J is aryl or heteroaryl;
K is aryl or heteroaryl;
each R 4 and R 41 is independently halogen, heteroaryl, heterocyclyl, -G 1 , -E- G 1 , or -D-E- G 1 ,
wherein
D is —O—;
E is —[C(R 15 ) 2 ] m — or —C 3 -C 6 cycloalkyl; and
G 1 is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,
L 2 is a bond;
q is 1, 2, or 3, and
q′ is 0, 1, 2 or 3,
each R 11 is independently -hydrogen, —C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —C 1 -C 6 haloalkyl, —N(R 12 ) 2 , aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl, wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;
each R 12 is independently halogen, OR 13 , N(R 13 ) 2 , C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0-6 alkoxyaryl, arylC 0-6 alkylcarboxy, C 0 -C 6 alkyl, —NR 13 SO 2 R 13 , or —OC 0-6 alkylCOOR 13 ;
each R 13 is independently hydrogen C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl) C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-.
24. A compound which is one of the species selected from the group consisting of:
Cpd #
Structure
Name
1
2-(2-(2-fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
2
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol;
3
2-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
4
2-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
5
2-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
6
2-(2-(2,6- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
7
2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
8
2-(2-(2,6- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
9
2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
10
2-(2-(2-chloro-6- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
11
2-(2-(2,3- dichlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
12
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
13
3-(2-(2-chlorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
14
3-(2-(2-chlorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
15
3-(2-(2-chlorobenzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
16
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
17
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(3′-(ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
18
2-(2-(5-chloro-2- (trifluoromethyl)benzyl)- 1-(4′-(hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
19
2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
20
2-(2-(2-(2- chlorophenyl)propan-2- yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
21
2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
22
2-(2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
23
2-(2-(2,3- dichlorobenzyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
24
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
25
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
26
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol;
27
2-(2-(2- chlorophenethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
28
2-(2-(2- chlorophenethyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
29
2-(2-(2- chlorophenethyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
30
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
31
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(naphthalen-1- yl)-1H-imidazol-4- yl)propan-2-ol;
32
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(naphthalen- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
33
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin- 1-yl)-1H-imidazol-4- yl)propan-2-ol;
34
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(isoquinolin-1- yl)-1H-imidazol-4- yl)propan-2-ol;
35
2-(2-(isoquinolin-5-yl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
36
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(isoquinolin-5-yl)- 1H-imidazol-4- yl)propan-2-ol;
37
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
38
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
39
2-(1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(4- (trifluoromethyl)pyridin- 3-yl)-1H-imidazol-4- yl)propan-2-ol;
40
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- morpholinoethyl)-1H- imidazol-4-yl)propan-2-ol;
41
2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(thiophen-2- yl)-1H-imidazol-4- yl)propan-2-ol;
42
2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
43
2-(2-(1,5-dimethyl-1H- pyrrol-2-yl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
44
2-(1-(2,6- dichlorophenyl)-2-(5-(3- (methylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
45
2-(1-(2,6- dichlorophenyl)-2-(5-(3- (ethylsulfonyl)phen- yl)thiophen-2-yl)-1H- imidazol-4-yl)propan-2-ol;
46
1-(2,5-dichlorophenyl)- 2-{5-[3- (methylsulfonyl)phen- yl]-2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
47
1-(2-chlorophenyl)-2- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-4- (trifluoromethyl)-1H- imidazole;
48
methyl (4-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3- methylphenyl)acetate;
49
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
50
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
51
5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
52
4-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)morpholine;
53
1,1-dimethylethyl 4-(5- {5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine-1- carboxylate;
54
1-(5-{5-[1-(2,5- dichlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}pyridin-2- yl)piperazine;
55
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2-(ethylthio)-3- methylpyridine;
56
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-3-methyl-2- (methylsulfonyl)pyridine;
57
5-{5-[1-(2- chlorophenyl)-4- (trifluoromethyl)-1H- imidazol-2-yl]-2- thienyl}-2- (ethylsulfonyl)-3- methylpyridine;
58
2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
59
2-(1-(2-isopropyl-6- methylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
60
2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropyl-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
61
2-(1-(2- isopropylphenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
62
2-(2-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 1-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
63
2-(1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
64
2-(1-(2,6- dichlorophenyl)-2-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
65
2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
66
2-(2-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
67
1,1,1-trifluoro-2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
68
ethyl 1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxylate;
72
3-(2-(2,3- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
73
3-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
74
3-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)pentan-3-ol;
80
N-benzyl-3′-chloro-4′- (2-(2-chloro-6- fluorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide;
81
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-ethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
82
2-(2,6-dichlorophenyl)- N-ethyl-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
83
(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)(4-methylpiperazin- 1-yl)methanone;
84
2-(2,6-dichlorophenyl)- N-(2-hydroxyethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
85
2-(2,6-dichlorophenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
86
2-(2,6-dichlorophenyl)- N,N-diethyl-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
87
2-(2,6-dichlorophenyl)- 1-(3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
88
2-(2,6-dichlorophenyl)- N-(2-fluoroethyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide;
89
2-(2-isopropylphenyl)- 1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-N-(2,2,2- trifluoroethyl)-1H- imidazole-4-carboxamide;
90
2-(2-(2- (dimethylamino)-6- fluorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
91
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
92
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
93
2-(2-(2-ethylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
94
2-(2-(2- isopropylphenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
95
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
96
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
97
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
98
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
99
2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
100
2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
101
2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
102
2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
103
2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
104
2-(2,6-dichlorophenyl)- 1-(3′-(ethylsulfonyl)-3- methylbiphenyl-4-yl)- N-(2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide;
105
2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
106
2-(2-(2,6- dichlorophenyl)-1-(3′- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
107
2-(1-(2′-chloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
108
4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-N- methylbiphenyl-3- sulfonamide;
109
2-(1-(3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
110
2-(1-(3′-(ethylsulfonyl)- 3-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
111
2-(1-(2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
112
2-(1-(3′-(ethylsulfonyl)- 2-fluorobiphenyl-4-yl)- 2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
113
2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
114
2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
115
2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
116
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
117
2-(2-(2,3- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
118
2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
119
2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
120
2-(2-(3-chloro-2- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
121
2-(1-(3-fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
122
2-(2-(2,6- dichlorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
123
2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
124
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
125
2-(2-(2-chloro-3- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
126
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
127
2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
128
2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
129
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
130
2-(2-(2,6- difluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
131
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
132
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
133
2-(2-(2-chloro-6- methylphenyl)-1-(3- fluoro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
134
2-(2-(2-chloro-6- fluorophenyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
135
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
136
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
137
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
138
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
139
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
140
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
141
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
142
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
143
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
144
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
145
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
146
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
147
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
148
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
149
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
150
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
151
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
152
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-3- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
153
2-(2-(2-chloro-3- fluorophenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
154
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
155
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
156
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- methylphenyl)-1H- imidazol-4-yl)propan-2-ol;
157
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
158
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
159
2-(1-(3-chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- difluorophenyl)-1H- imidazol-4-yl)propan-2-ol;
160
2-(2-(3-chloro-2- methylphenyl)-1-(3- chloro-4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
161
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- isopropylphenyl)-1H- imidazol-4-yl)propan-2-ol;
162
2-(3′-chloro-4′-(2-(2- chlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
163
2-(1-(3-chloro-4′-(2- hydroxypropan-2-yl)-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
164
2-(3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-yl)propan-2-ol;
165
ethyl 3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl-3- (methylsulfonyl)biphenyl- 4-carboxylate;
166
(3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)(morpholino)methanone;
167
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N,N-dimethyl-3- (methylsulfonyl)biphenyl- 4-carboxamide;
168
2-(1-(3-chloro-5- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
169
2-(1-(3-chloro-3′- (ethylsulfonyl)-5- methylbiphenyl-4-yl)-2- (2-chlorophenyl)-1H- imidazol-4-yl)propan-2-ol;
170
2-(2-(2-chlorophenyl)- 1-(3-ethyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
171
2-(1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
172
2-(2-(2-chloro-6- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
173
2-(2-(2-chloro-3- fluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
174
2-(2-(2,6- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
175
2-(2-(3-chloro-2- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
176
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
177
2-(2-(2-chloro-6- methylphenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
178
2-(2-(2,6- difluorophenyl)-1-(4′- (hydroxymethyl)-3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
179
2-(2-(2,3- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
180
2-(2-(2,3- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
181
2-(2-(2,6- dichlorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
182
2-(2-(2,6- dichlorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
183
2-(1-(3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
184
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)-2-(2- (trifluoromethyl)phenyl)- 1H-imidazol-4- yl)propan-2-ol;
185
2-(2-(2-chloro-3- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
186
2-(2-(2-chloro-3- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
187
2-(2-(2-chloro-6- fluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
188
2-(2-(2-chloro-6- fluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
189
2-(2-(3-chloro-2- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
190
2-(2-(3-chloro-2- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
191
2-(2-(2-chloro-6- methylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
192
2-(2-(2-chloro-6- methylphenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
193
2-(2-(2,6- difluorophenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
194
2-(2-(2,6- difluorophenyl)-1-(3′- (ethylsulfonyl)-3- methylbiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol;
195
2-(2-(2- isopropylphenyl)-1-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
196
2-(1-(3′-(ethylsulfonyl)- 3-methylbiphenyl-4-yl)- 2-(2-isopropylphenyl)- 1H-imidazol-4- yl)propan-2-ol;
197
2-(1-(2,6- dichlorophenyl)-2-(3- methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol;
198
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
199
2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
200
2-{1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
201
2-{1-[3′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
202
2-{1-[2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
203
2-{1-(2′,3′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
204
2-(1-{4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
205
2-{1-(4′-fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
206
2-{1-(3′-fluorobiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
207
2-{1-(2′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
208
2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
209
2-{1-(4′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
210
2-{1-(4-pyrimidin-5- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
211
2-{1-[4′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
212
2-{1-[4′- (dimethylamino)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
213
2-{1-[4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
214
2-{1-[4′-(1- methylethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
215
2-{1-[4′-chloro-2′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
216
2-{1-(2′,3′,4′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
217
2-{1-(3′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
218
2-{1-(2′-chloro-6′- fluoro-3′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
219
2-{1-[5′-chloro-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
220
2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
221
2-{1-[2′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
222
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
223
2-{1-[4-(1,3- benzodioxol-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
224
2-(1-{4-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
226
2-{1-(3′- chlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
227
2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
228
ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylate;
229
2-{1-(4-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
230
2-{1-[3′-chloro-4′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
232
2-{1-[2′-fluoro-3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
233
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
234
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}biphenyl-4- carboxamide;
235
2-(1-{4′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
236
2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
237
2-{1-(4′- propylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
238
2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
239
2-(1-{2′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
240
2-(1-{3′-chloro-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
241
2-{1-[4-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
242
2-{1-[4′- (methylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
243
2-{1-[3′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
244
2-{1-[3′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
245
2-{1-(4′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
246
2-{1-(2′,4′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
247
2-{1-(3′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
248
2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
249
2-{1-(4-naphthalen-2- ylphenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
250
2-{1-[3′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol
251
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-ol;
252
2-{1-(3′,4′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
253
1-[5-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
254
2-{1-(3′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
255
2-{1-(3′-chloro-4′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
256
2-{1-[5′-methyl-2′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
257
2-{1-(2′,5′- difluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
258
2-{1-[3′- (butyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
259
2-{1-[5′-chloro-2′- (ethyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
260
2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
261
2-{1-(2′,3′,5′- trifluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
262
2-{1-[3′- (ethylthio)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
263
2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
264
2-{1-[4-(1-benzothien- 3-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
265
2-{1-[4-(4- methylnaphthalen-1- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
266
2-{1-(2′,4′- dichlorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
267
2-{1-[3′,4′- bis(methyloxy)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
268
2-{2-[2- (trifluoromethyl)phenyl]- 1-(2′,4′,5′- trimethylbiphenyl-4- yl)-1H-imidazol-4- yl}propan-2-ol;
269
4-fluoro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2-ol;
270
2-{1-[2′- (hydroxymethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
271
2-{1-[3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl]propan-2-ol;
272
2-{1-(2′-chloro-6′- fluorobiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
273
2-{1-[3′,5′-difluoro-2′- (methyloxy)biphenyl-4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
274
2-(1-{4-[2- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
275
2-{1-[2′-methyl-5′- (methyloxy)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
276
2-{1-(2′-ethylbiphenyl- 4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
277
2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
278
2-{1-[4′- (ethylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
279
2-{1-(5′-fluoro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
280
2-{1-[3′-chloro-4′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
281
2-{1-(5′-chloro-2′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
282
2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
283
2-{1-(3′-fluoro-4′- methylbiphenyl-4-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
284
methyl (2E)-3-(4′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4-yl)prop- 2-enoate;
285
N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
286
2-{1-[4-(2,3-dihydro-1- benzofuran-5- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
287
2-(1-{3-[6- (methyloxy)pyridin-3- yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
288
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-sulfonamide;
289
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxamide;
290
2-(1-{3-[2- (cyclopentyloxy)pyridin- 3-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
291
2-{1-(3′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
292
2-{1-[2′-fluoro-5′- (methyloxy)biphenyl-3- yl]-2-[2 (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
293
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
294
2-{1-[3′,4′- bis(methyloxy)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
295
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-2- yl)methanesulfonamide;
296
2-{1-[3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
297
3-fluoro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
298
4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
299
2-{1-(3-{2-[(1- methylethyl)oxy]pyridin- 3-yl}phenyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
300
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)acetamide;
301
2-{1-[2′-methyl-5′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
302
N-(3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- yl)acetamide;
303
2-{1-(4′- chlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
304
2-{1-[4′- (phenyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
305
2-{1-[5′-fluoro-2′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
306
2-{1-(2′,3′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
307
2-(1-{3′- [(trifluoromethyl)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
308
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
309
2-{1-[3′,5′- bis(trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
310
2-{1-(3′,5′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
311
3-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- (1-methylethyl)biphenyl- 4-carboxamide;
312
N,N-diethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
313
4-chloro-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 3-carboxamide;
314
2-{1-[3′- (methyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
315
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxylic acid;
316
N-ethyl-3′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-l- yl}biphenyl-3- carboxamide;
317
4-chloro-N-ethyl-3′-{4- (1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- carboxamide;
318
2-{1-(2′,5′- difluorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
319
2-(1-{3′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
320
2-{1-[2′-fluoro-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
321
2-{1-(3′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
322
2-{1-[3′- (ethyloxy)biphenyl-3- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
323
2-(1-{2′-methyl-4′-[(1- methylethyl)oxy]biphenyl- 3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
324
2-{1-[3-(1-methyl-1H- indol-5-yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
325
2-{1-[4′-(ethyloxy)-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
326
2-{1-[3′- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
327
2-{1-[2′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
328
2-{1-[3′- (hydroxymethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
329
2-{1-[3-(1H-indol-4- yl)phenyl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
330
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
331
1-[5-(3-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}phenyl)-2- thienyl]ethanone;
332
2-{1-(5′-chloro-2′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
333
2-(1-{4′- [(trifluoromethy)oxy]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
334
2-{1-[2′-chloro-4′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
335
2-{1-(2′,5′- dichlorobiphenyl-3-yl)- 2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
336
2-{1-[2′-(ethyloxy)-5′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
337
3′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N-(1- methylethyl)biphenyl- 4-carboxamide;
338
2-{1-(2′,4′- dichlorobiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
339
2-{1-[4- (ethylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
340
2-{1-[4′-fluoro-3′- (trifluoromethyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
341
2-{1-(3′-fluoro-4′- methylbiphenyl-3-yl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
342
N-butyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
343
N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-6- methylbiphenyl-3- sulfonamide;
344
4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-N- methylbiphenyl-3- sulfonamide;
345
N-ethyl-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
346
N-(1,1-dimethylethyl)- 4′-{4-(1-hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- sulfonamide;
347
2-{1-[2′-amino-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
348
2-{1-[3′-fluoro-5′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
349
2-{1-[4′-chloro-3′- (trifluoromethyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
350
3-chloro-4′-{4-(1- hydroxy-1- methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-4- carboxylic acid;
351
2-(2-[2- (trifluoromethyl)phenyl]-1-{3′- [(trifluoromethyl)thio]bi- phenyl-4-yl}-1H- imidazol-4-yl)propan-2-ol;
352
2-{1-[3′-(morpholin-4- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
353
2-(1-{4-[5- (hydroxymethyl)-1,3- thiazol-2-yl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
354
2-{1-[2′-methyl-5′- (piperidin-1- ylsulfonyl)biphenyl-4- yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
355
1-[4-(4-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1 yl}phenyl)-2- thienyl]ethanone;
356
2-(1-{4-[5- (hydroxymethyl)-3- thienyl]phenyl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
357
4-(2-chlorophenyl)-5- {5-[3- (methylsulfonyl)phenyl]- 2-thienyl}-2- (trifluoromethyl)-1H- imidazole;
358
2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-1H- imidazole;
359
4-(2-chlorophenyl)-5-[3′- (methylsulfonyl)biphenyl- 4-yl]-2- (trifluoromethyl)-1H- imidazole;
360
4′-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl- 3-sulfonamide;
361
4′-[4-(2-chlorophenyl)- 2-(trifluoromethyl)-1H- imidazol-5-yl]biphenyl- 3-sulfonamide;
362
3-{5-[4-(2- chlorophenyl)-2- (trifluoromethyl)-1H- imidazol-5-yl]-2- thienyl}benzenesulfonamide;
364
1-[3′- (methylsulfonyl)biphenyl- 4-yl]-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
365
4′-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3-sulfonamide;
367
ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole-4- carboxylate;
369
5-[3- (methylsulfonyl)phenyl]-2-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
370
2-[2-(2-chlorophenyl)- 4-(trifluoromethyl)-1H- imidazol-l-yl]-5-[3- (methylsulfonyl)phen- yl]pyridine;
371
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
372
5-{3-[(1- methylethyl)sulfonyl]phenyl}- 2-{4-(trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}pyridine;
373
1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazole;
375
N-(4′-{4- (trifluoromethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1- yl}biphenyl-3- yl)methanesulfonamide;
376
ethyl 1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazole-4-carboxylate;
378
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-phenyl-1H- imidazol-4-yl}propan-2-ol;
379
2-{2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
380
2-{2-(2-fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
382
2-{2-(2,3- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
383
2-{2-(2-chloro-3- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
384
4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-l-yl]biphenyl- 3-sulfonamide;
385
2-{2-(4-fluorophenyl)-1-[3′- (methylsulfony)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
386
2-{2-(2-chlorophenyl)- 1-[3-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
387
2-{2-(2-chlorophenyl)- 1-[2-fluoro-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
388
2-{2-(2-chlorophenyl)- 1-[3′-(1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
389
2-{2-(2-chlorophenyl)- 1-[4′-(1,1- dimethylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
390
methyl 4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylate;
391
N-{4′-[2-(2- chlorophenyl)-4-(1- hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-yl}-1,3- benzodioxole-5- carboxamide;
392
2-{1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[3- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
393
2-{2-(3-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
394
2-{2-(2-chloro-6- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
395
4′-[2-(2-chlorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]biphenyl- 3-carboxylic acid;
397
2-(2-chlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-N-(2,2,2- trifluoroethyl)-1H- imidazole-4- carboxamide;
399
2-{1-[4′-(methyloxy)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
400
2-{1-[4′- (hydroxymethyl)-3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
401
ethyl 4′-{4-(1-hydroxy- 1-methylethyl)-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-1-yl}-5- (methylsulfonyl)biphenyl- 3-carboxylate;
402
2-{5-bromo-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
403
2-{5-chloro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
404
2-{1-[4′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
405
2-[1-(3′-aminobiphenyl- 4-yl)-2-(2- chlorophenyl)-1H- imidazol-4-yl]propan-2-ol;
406
2-{5-fluoro-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
407
2-{1-[4′- (methylsulfonyl)biphenyl- 3-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
409
2-{2-(2-chlorophenyl)- 1-[3′-(1-hydroxy-1- methylethyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
410
2-{2-(2,6- difluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
413
2-(1-{3-[(1- methylethyl)sulfonyl]bi- phenyl-4-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
414
2-(1-{3′-[(1- methylethyl)sulfonyl]bi- phenyl-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
415
2-{2-(2-chlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
416
2-{2-(2-chloro-6- fluorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
417
2-{1-[3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl]-2-(2- chlorophenyl)-1H- imidazol-4-yl}propan-2-ol;
418
2-{2-(2-chlorophenyl)- 1-[3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
419
2-{2-[2,6- difluorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
420
2-(1-{5-[3- (methylsulfonyl)phen- yl]pyridin-2-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
421
2-(1-{6-[3- (methylsulfonyl)phen- yl]pyridin-3-yl}-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl)propan-2-ol;
422
2-{2-(2,6- dichlorophenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
427
2-{2-(2,3- dichlorophenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
428
2-{5-methyl-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-[2- (trifluoromethyl)phenyl]- 1H-imidazol-4- yl}propan-2-ol;
429
2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-3- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
430
2-{2-[2-fluoro-6- (trifluoromethyl)phenyl]- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
431
2-{2-(2-methylphenyl)- 1-[3′-(methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
432
2-(1-[3′- (methylsulfonyl)biphenyl- 4-yl]-2-{2- [(trifluoromethyl)oxy]phen- yl}-1H-imidazol-4- yl)propan-2-ol;
436
2-(1-(2′,5′- dimethylbiphenyl-4-yl- 2-(2-trifluoromethyl)phen- yl)1H-imidazol-4- yl)propan-2-ol;
437
2-{2-(2-chlorophenyl)- 1-[3′-(ethylsulfonyl)-2- fluorobiphenyl-4-yl]- 1H-imidazol-4- yl}propan-2-ol;
438
2-{2-(3-chloro-2- methylphenyl)-1-[3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
439
2-{2-(2-chlorophenyl)- 1-[2-methyl-3′- (methylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
440
2-{2-(3-chloro-2- methylphenyl)-1-[3′- (ethylsulfonyl)biphenyl- 4-yl]-1H-imidazol-4- yl}propan-2-ol;
443
2-(1-(2-chlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
444
2-(1-(2,3- dichlorobenzyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
445
2-(5-chloro-2-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-1-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
446
2-(5-chloro-1-(2,6- dichlorophenyl)-2-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
447
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxylic acid
448
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)- N-methoxy-N-methyl-3- (methylsulfonyl)biphenyl- 4-carboxamide
449
2-(2-(2,3- dichlorobenzyl)-1-(3- fluoro-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
450
2-(2-(2,3- dichlorobenzyl)-1-(3′- (ethylsulfonyl)-3- fluorobiphenyl-4-yl)- 1H-imidazol-4- yl)propan-2-ol
451
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
452
2-(1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2-(2,3- dichlorophenyl)propan- 2-yl)-1H-imidazol-4- yl)propan-2-ol
453
3′-chloro-4′-(2-(2- chloro-6-fluorophenyl)- 4-(2-hydroxypropan-2- yl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl- 4-carboxamide
454
2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2-chloro-6- fluorophenyl)-1H- imidazol-4-yl)propan-2-ol
455
2-(2-(2,3- dichlorophenyl)-1-(4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
456
2-(2-(2,3- dichlorobenzyl)-1-(4′- methoxy-3-methyl-3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
457
2-(1-(3-chloro-4′- methoxy-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
458
2-(2-(3-chloro-3′- (methylsulfonyl)biphenyl- 2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
459
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
460
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- fluoroethyl)-1H- imidazole-4- carboxamide
461
2-(1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4- carboxamido)acetic acid
462
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N- (2,2,2-trifluoroethyl)- 1H-imidazole-4- carboxamide
463
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
464
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(1- hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
465
N-tert-butyl-1-(3- chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazole-4-carboxamide
466
2-chloro-4′-(2-(2,6- dichlorophenyl)-4-(2- hydroxypropan-2-yl)- 1H-imidazol-1-yl)-3′- methylbiphenyl-4- carboxylic acid
467
2-(1-(2′,3-dichloro-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-1H- imidazol-4-yl)propan-2-ol
468
2-(1-(2′-chloro-3- methyl-5′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,3- dichlorobenzyl)-1H- imidazol-4-yl)propan-2-ol
469
6-{3-chloro-4-[2-(2- chloro-6-fluorophenyl)- 4-(1-hydroxy-1- methylethyl)-1H- imidazol-1-yl]phenyl}- 2,3-dihydro-1- benzothiophene-3-ol 1,1-dioxide
470
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4- carboxamide
471
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxyethyl)-1H- imidazole-4-carboxamide
472
1-(3-chloro-3′- (methylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4- carboxamide
473
1-(3-chloro-3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(2,6- dichlorophenyl)-N-(2- hydroxy-2- methylpropyl)-1H- imidazole-4-carboxamide
474
2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
475
2-(2-(2,3- dichlorophenyl)-1-(4′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
476
2-(2-(2,3- dichlorophenyl)-1-(3′- (hydroxymethyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
477
2-(2-(2,3- dichlorophenyl)-1-(4′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
478
2-(2-(2,3- dichlorophenyl)-1-(3′- (2-hydroxypropan-2- yl)biphenyl-4-yl)-1H- imidazol-4-yl)propan-2-ol
479
2-(2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)-2-methylpropan-1-ol
480
1-(3-chloro-3′-(2- hydroxypropan-2- yl)biphenyl-4-yl)-2- (2,6-dichlorophenyl)-N- (1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4-carboxamide
481
2-(2,6-dichlorophenyl)- N-(1-hydroxy-2- methylpropan-2-yl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide
482
2-(2-(5-chloro-2- fluorobenzyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
483
2-(2-(3-chloro-2- fluorobenzyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazol-4- yl)propan-2-ol
484
2-(1-(3′- (methylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
485
2-(1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-2-(3- (trifluoromethyl)benzyl)- 1H-imidazol-4- yl)propan-2-ol
486
2-(2,6-dichlorophenyl)-1-(3′- (ethylsulfonyl)biphenyl- 4-yl)-N-(1-hydroxy-2- methylpropan-2-yl)- 1H-imidazole-4- carboxamide, and
487
N-tert-butyl-2-(2,6- dichlorophenyl)-1-(3′- (methylsulfonyl)biphenyl- 4-yl)-1H-imidazole- 4-carboxamide.
25. A pharmaceutical composition comprising a compound of claim 8 , or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier.
26. The compound according to claim 17 , of the formula,
or a pharmaceutically acceptable salt thereof.
27. The compound according to claim 4 , wherein R 2 is -halogen, —CF 3 , —CH 2 OH, or —C(CH 3 ) 2 OH.
28. A compound which is
or a pharmaceutically acceptable salt thereof.
29. The compound of claim 23 , wherein the compound is according to formula IIa.
30. The compound of claim 23 , wherein the compound is according to formula IIb.
31. A pharmaceutical composition comprising a compound of claim 28 , or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier.