Modulators of LXR

1. A compound according to one of the following formulas,

or a pharmaceutically acceptable salt thereof, wherein,

(A) R 1 is -L 1 -R 5 , wherein

L 1 is a bond, L 5 , or L 6 , wherein L 5 is —[C(R 15 ) 2 ] 2 —, wherein

each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 1 -C 6 )haloalkyl;

L 6 is C 3 -C 8 cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl, wherein the cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl are optionally substituted with one or more radicals of R 14 ;

R 5 is aryl, or heteroaryl, wherein R 5 is optionally substituted with one or more R 5a , wherein

each R 5a is independently halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, nitro, heterocyclyloxy, aryl, aryloxy, arylalkyl, aryloxyaryl, aryl C 1 -C 6 alkoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-;

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl,

R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —Z, or —Y—Z, wherein

Y is —[C(R 15′ ) 2 ] m — or C 2 -C 6 alkenyl,

wherein each R 15′ is independently H, halogen, or (C 1 -C 6 )alkyl; and

Z is —H, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —C(═N—OH)R 11 , or —C(═S)N(R 11 ) 2 ;

R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

provided that R 2 and R 21 are not simultaneously —H;

each R 10 is independently —R 11 , —C(═O)R 11 , —CO 2 R 11 , or —SO 2 R 11 ;

each R 11 is independently -hydrogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —N(R 12 ) 2 , —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,

wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;

each R 12 is independently hydrogen, halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCN, C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkylNR 13 SO 2 R 13 , —C 0 -C 6 alkylN(R 13 ) 2 , or OC 0 -C 6 alkylCOOR 13 ;

each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;

each R 14 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, C 1 -C 6 haloalkyl, C 0 -C 6 alkylCON(R 11 ) 2 , C 0 -C 6 alkylCONR 11 OR 11 , C 0 -C 6 alkylOR 11 , or C 0 -C 6 alkylCOOR 11 ;

G is a group of the formula,

wherein

J is thienyl;

K is phenyl;

each R 4 is independently halogen, nitro, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl, CR 11 ═CR 11 COOR 11 , aryloxy, —S-aryl, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkoxyheteroaryl, C 0 -C 6 alkoxyheterocyclyl, aryl, heteroaryl, heterocyclyl, -M, -E-M, or -D-E-M, wherein

D is —O—;

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 1 ,

wherein at least one R 4 is -M or -E-M, wherein

E is —[C(R 15 ) 2 ] m —;

M is —COOR 11 , —OR 11 , —SO 2 R 11 , or —SO 2 N(R 11 ) 2 ;

wherein each R 4 is optionally substituted with one or more R 4a ,

wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, —C 1 -C 6 alkyl-aryl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, -M′, -E′-M′, or -D′-E′-M′

D′ is —O—;

E′ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M′ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, COR 11 , —CON(R 11 ) 2 , —N(R 11 )COOR 11 , —N(R 11 ) 2 , COOR 11 , C≡N, OR 11 , —NR 11 COR 11 , NR 11 SO 2 R 11 , SO 2 R 11 , SO 2 N(R 11 ) 2 , or SR 11 ;

each R 41 is independently halogen, nitro, C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -M″, -E″-M″, or -D″-E″-M″, wherein

D″ is —O—;

E″ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M″ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 41 is optionally substituted with one or more R 4a ;

L 2 is a bond, or L 2 is a C 2-6 alidiyl chain, wherein alidiyl chain is optionally interrupted by —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C(R 11 ) 2 O—, —C(R 11 ) 2 NR 11 —, —C(R 11 ) 2 NR 11 —, —C≡C—, —O—, —S—, —N(R 10 )CO—, —N(R 10 )CO 2 —, —CON(R 10 )—, —CON(R 11 )—, —CON(R 11 )O—, —CO—, —CO 2 —, —OC(═O)—, —OC(═O)N(R 10 )—, —SO 2 —, —N(R 10 )SO 2 —, —SO 2 N(R 10 )—; aryl, C 3 -C 8 cycloalkyl, heteroaryl, or heterocyclyl

wherein the aryl, cycloalkyl, heteroaryl, or heterocyclyl is optionally substituted with one or more R 9 , wherein

each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;

each m is independently 0, 1, 2, 3, 4, 5 or 6;

q is 1, 2, 3, 4 or 5; and

q′ is 0, 1, 2, 3, or 4,

(B) provided that,

(i) if the compound is defined by formula Ia, then R 1 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl;

(ii) if the compound is defined by formula Id, then

(a) if L 1 is a bond, then R 1 is not thienyl or 5-methylthienyl; and

(b) R 1 is not 4-Me-phenyl.

2. The compound according to claim 1 , of the formula

or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 2 , of the formula,

or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 3 , of the formula,

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 4 , wherein L 1 is a bond; and R 5 is phenyl optionally substituted with one or more R 5a .

6. The compound according to claim 5 , wherein each R 5a is independently halogen, nitro, heterocyclyloxy, aryloxy, —C′, —B′—C′ or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m —; and

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl.

7. The compound according to claim 6 , wherein each R 5a is independently halogen, nitro, heterocyclyloxy, phenoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m —;

C′ is —H, halogen, —OR 18 , —COR 18 , —C≡N, —C(O)OR 18 , —OC(═O)R 18 , —CON(R 18 ) 2 , —OCON(R 18 ) 2 , —NR 18 COR 18 , —NR 18 CON(R 18 ) 2 , —NR 18 COOR 18 , —N(R 18 ) 2 , or heterocyclyl;

wherein each R 18 is independently —H, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl.

8. The compound according to claim 5 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 16 , —COOR 16 , —CON(R 16 ) 2 , —C≡N, —OR 16 , or —N(R 16 ) 2 ,

wherein each R 16 is independently hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

9. The compound according to claim 8 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

10. The compound according to claim 5 , wherein each R 4 is independently halogen, nitro, CR 11 ═CR 11 COOR 11 , -M, or -E-M, wherein

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 —,

wherein at least one R 4 is -M or -E-M, wherein

E is —[C(R 15 ) 2 ] m —;

M is —COOR 11 , —OR 11 , —SO 2 R 11 , or —SO 2 N(R 11 ) 2 .

11. The compound according to claim 10 , wherein each R 4 is independently halogen, CR 11′ ═CR 11′ COOR 11′ , -M, or -E-M, wherein

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11 ) 2 , —C≡N, —OR 11′ , —NR 11′ SO 2 R 11′ , —N(R 11′ ) 2 , —SO 2 R 11′ , —SO 2 NR 11′ COR 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein at least one R 4 is -M or -E-M, wherein

E is —[C(R 15 ) 2 ] m —;

M is —COOR 11′ , —OR 11′ , —SO 2 R 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl,

wherein any of R 11′ is optionally substituted with one or more radicals of R 12′ ;

each R 12′ is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C═O(OR 13 ), COR 13 , SO 2 R 13 , CON(R 13 ) 2 , SO 2 N(R 13 ) 2 , or —N(R 13 ) 2 .

12. The compound according to claim 11 , wherein R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —C 1 -C 3 alkyl, —C 1 -C 3 haloalkyl, or —(C(R 15 ) 2 )—Z, wherein

Z is −OR 11″ wherein R 11″ is —H or C 1 -C 6 alkyl.

13. The compound according to claim 7 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

14. The compound according to claim 9 , wherein each R 4 is independently halogen, CR 11′ ═CR 11′ COOR 11′ , -M, or -E-M, wherein

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11′ ) 2 , —C≡N, —OR 11′ , —NR 11′ SO 2 R 11′ , —N(R 11′ ) 2 , —SO 2 R 11′ , —SO 2 NR 11′ COR 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein at least one R 4 is -M or -E-M, wherein

E is —[C(R 15 ) 2 ] m —;

M is —COOR 11′ , —OR 11′ , —SO 2 R 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl,

wherein each R 11′ is optionally substituted with one or more radicals of R 12′ ;

each R 12′ is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C═O(OR 13 ), COR 13 , SO 2 R 13 , CON(R 13 ) 2 , or —N(R 13 ) 2 .

15. The compound according to claim 11 , wherein each R 5a is independently halogen, nitro, heterocyclyloxy, phenoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m —;

C′ is —H, halogen, —OR 18 , —COR 18 , —C≡N, —C(O)OR 18 , —OC(═O)R 18 , —CON(R 18 ) 2 , —OCON(R 18 ) 2 , —NR 18 COR 18 , —NR 18 CON(R 18 ) 2 , —NR 18 COOR 18 , —N(R 18 ) 2 , or heterocyclyl;

wherein each R 18 is independently —H, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl.

16. The compound according to claim 12 , wherein each R 4 is independently halogen, CR 11′ ═CR 11′ COOR 11′ , -M, or -E-M, wherein

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11′ ) 2 , —C≡N, —OR 11′ , —NR 11′ SO 2 R 11′ , —N(R 11′ ) 2 , —SO 2 R 11′ , —SO 2 NR 11′ COR 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein at least one R 4 is -M or -E-M, wherein

E is —[C(R 15 ) 2 ] m —;

M is —COOR 11′ , —OR 11 , —SO 2 R 11′ , or —SO 2 N(R 11′ ) 2 ,

wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl,

wherein any of R 11′ is optionally substituted with one or more radicals of R 12′ ;

each R 12′ is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C═O(OR 13 ), COR 13 , SO 2 R 13 , CON(R 13 ) 2 , SO 2 N(R 13 ) 2 , or —N(R 13 ) 2 .

17. The compound according to claim 11 , wherein each R 5a is independently halogen, nitro, heterocyclyloxy, phenoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m —;

C′ is —H, halogen, —OR 18 , —COR 18 , —C≡N, —C(O)OR 18 , —OC(═O)R 18 , —CON(R 18 ) 2 , —OCON(R 18 ) 2 , —NR 18 COR 18 , —NR 18 CON(R 18 ) 2 , —NR 18 COOR 18 , —N(R 18 ) 2 , or heterocyclyl;

wherein each R 18 is independently —H, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl.

18. The compound according to claim 15 , wherein each R 41 is independently hydrogen, halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

19. A compound according to formula:

or a pharmaceutically acceptable salt thereof, wherein

(A) R 1 is -L 1 -R 5 , wherein

L 1 is -L 5 - or -L 6 -, wherein

each L 5 is —C(R 15 ) 2 —,

wherein

each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, or (C 1 -C 6 )halo alkyl; and

L 6 is C 3 -C 8 cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl, wherein the cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl are optionally substituted with one or more radicals of R 14 ;

R 5 is aryl or heteroaryl optionally substituted with one or more R 5a , wherein

each R 5a is independently halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, nitro, heterocyclyloxy, aryl, aryloxy, arylalkyl, aryloxyaryl, aryl C 1 -C 6 alkoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-;

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —COR 11 , —SON(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl;

R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —Z, or —Y—Z, wherein

Y is —[C(R 15′ ) 2 ] m — or C 2 -C 6 alkenyl,

wherein each R 15′ is independently H, halogen, or (C 1 -C 6 )alkyl; and

Z is —H, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —C(═N—OH)R 11 , or —C(═S)N(R 11 ) 2 ;

R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

provided that R 2 and R 21 are not simultaneously —H;

each R 4 is independently halogen, nitro, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl, CR 11 ═CR 11 COOR 11 , aryloxy, —S-aryl, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkoxyheteroaryl, C 0 -C 6 alkoxyheterocyclyl, aryl, heteroaryl, heterocyclyl, -M, -E-M, or -D-E-M, wherein

D is —O—;

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 4 is optionally substituted with one or more R 4a ,

wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, —C 1 -C 6 alkyl-aryl, C 1 -C 6 alkoxyaryl, awl C 0 -C 6 alkylcarboxy, -M′, -E′-M′, or -D′-E′-M′

D′ is —O—;

E′ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M′ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, COR 11 , —CON(R 11 ) 2 , —N(R 11 )COOR 11 , —N(R 11 ) 2 , COOR 11 , C≡N, OR 11 , —NR 11 COR 11 , NR 11 SO 2 R 11 , SO 2 R 11 , SON(R 11 ) 2 , or SR 11 ;

each R 41 is independently halogen, nitro, C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -M″, -E″-M″, or -D″-E″-M″, wherein

D″ is —O—;

E″ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M″ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 41 is optionally substituted with one or more R 4a ;

each R 11 is independently -hydrogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —N(R 12 ) 2 , —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,

wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;

each R 12 is independently hydrogen, halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCN, C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkylNR 13 SO 2 R 13 , —C 0 -C 6 alkylN(R 13 ) 2 , or OC 0 -C 6 alkylCOOR 13 ;

each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;

each R 14 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, C 1 -C 6 haloalkyl, C 0 -C 6 alkylCON(R 11 ) 2 , C 0 -C 6 alkylCONR 11 OR 11 , C 0 -C 6 alkylOR 11 , or C 0 -C 6 alkylCOOR 11 ;

wherein the aryl, cycloalkyl, heteroaryl, or heterocyclyl is optionally substituted with one or more R 9 , wherein

each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;

each m is independently 0, 1, 2, 3, 4, 5 or 6;

q is 0, 1, 2, 3, 4 or 5; and

q′ is 0, 1, 2, 3, or 4,

(B) provided that R 1 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl.

20. The compound according to claim 19 , wherein

R 5 is phenyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, pyridyl, pyrimidinyl, or pyrazinyl optionally substituted with one or more R 5a .

21. The compound according to claim 20 , wherein each R 5a is independently -halogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , —COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , or —N(R 11 ) 2 .

22. The compound according to claim 20 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

23. The compound according to claim 20 , wherein each R 4 is independently halogen —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11′ ) 2 , —C≡N, —OR 11′ , —N(R 11′ ) 2 , —SO 2 R 11′ , or —SO 2 N(R 11′ ) 2 , wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

24. The compound according to formula:

or a pharmaceutically acceptable salt thereof, wherein

(A) R 1 is -L 1 -R 5 , wherein

L 1 is a bond; and

R 5 is heteroaryl optionally substituted with one or more R 5a ,

wherein

each R 5a is independently halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, nitro, heterocyclyloxy, aryl, aryloxy, arylalkyl, aryloxyaryl, aryl C 1 -C 6 alkoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-;

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl;

R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —Z, or —Y—Z, wherein

Y is —[C(R 15′ ) 2 ] m — or C 2 -C 6 alkenyl,

wherein each R 15′ is independently H, halogen, or (C 1 -C 6 )alkyl; and

Z is —H, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —C(═N—OH)R 11 , or —C(═S)N(R 11 ) 2 ;

R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

provided that R 2 and R 21 are not simultaneously —H;

each R 4 is independently halogen, nitro, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl, CR 11 ═CR 11 COOR 11 , aryloxy, —S-aryl, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkoxyheteroaryl, C 0 -C 6 alkoxyheterocyclyl, aryl, heteroaryl, heterocyclyl, -M, -E-M, or -D-E-M, wherein

D is —O—;

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 4 is optionally substituted with one or more R 4a ,

wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, —C 1 -C 6 alkyl-aryl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, -M′, -E′-M′, or -D′-E′-M′

D′ is —O—;

E′ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M′ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, COR 11 , —CON(R 11 ) 2 , —N(R 11 )COOR 11 , —N(R 11 ) 2 , COOR 11 , C≡N, OR 11 , —NR 11 COR 11 , NR 11 SO 2 R 11 , SO 2 R 11 , SO 2 N(R 11 ) 2 , or SR 11 ;

each R 41 is independently halogen, nitro, C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -M″, -E″-M″, or -D″-E″-M″, wherein

D″ is —O—;

E″ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M″ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 41 is optionally substituted with one or more R 4a ;

each R 11 is independently -hydrogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —N(R 12 ) 2 , —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,

wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;

each R 12 is independently hydrogen, halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCN, C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkylNR 13 SO 2 R 13 , —C 0 -C 6 alkylN(R 13 ) 2 , or OC 0 -C 6 alkylCOOR 13 ;

each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;

wherein the aryl, cycloalkyl, heteroaryl, or heterocyclyl is optionally substituted with one or more R 9 , wherein

each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;

each m is independently 0, 1, 2, 3, 4, 5 or 6;

q is 0, 1, 2, 3, 4 or 5; and

q′ is 0, 1, 2, 3, or 4,

(B) provided that R 1 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl.

25. The compound according to claim 24 , wherein R 5 is thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, pyridyl, pyrimidinyl, or pyrazinyl optionally substituted with one or more R 5a .

26. The compound according to claim 25 , wherein R 5 is thienyl, furyl, pyrrolyl, thiazoyl, oxazoyl, isothiazoyl, or isoxazoyl optionally substituted with one or more R 5a .

27. The compound according to claim 26 , wherein each R 5a is independently -halogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , —COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , or —N(R 11 ) 2 .

28. The compound according to claim 26 , wherein each R 4 is independently halogen —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11′ ) 2 , —C≡N, —OR 11′ , —N(R 11 ) 2 , —SO 2 (R 11′ ) 2 , or —SO 2 N(R 11′ ) 2 , wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

29. The compound according to claim 26 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

30. The compound according to claim 25 , wherein R 5 is pyridyl, pyrimidinyl, or pyrazinyl optionally substituted with one or more R 5a .

31. The compound according to claim 30 , wherein each R 5a is -halogen, —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —OR 11 , —COR 11 , —C≡N, —C(O)OR 11 , —CON(R 11 ) 2 , or —N(R 11 ) 2 .

32. The compound according to claim 30 , wherein each R 4 is independently halogen —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11′ , —COOR 11′ , —CON(R 11′ ) 2 , —C≡N, —OR 11′ , —N(R 11 ) 2 , —SO 2 R 11′ , or —SO 2 N(R 11′ ) 2 , wherein each R 11′ is independently -hydrogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

33. The compound according to claim 30 , wherein each R 41 is independently halogen, —C 1 -C 6 alkyl, or —C 1 -C 6 haloalkyl.

34. A compound according to one of the following formulas:

or a pharmaceutically acceptable salt thereof, wherein

(A) R 1 is -L 1 -R 5 , wherein

L 1 is a bond, L 5 , or L 6 , wherein L 5 is —[C(R 15 ) 2 ] m —, wherein

each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 1 -C 6 )haloalkyl;

L 6 is C 3 -C 8 cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl, wherein the cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl are optionally substituted with one or more radicals of R 14 ;

R 5 is aryl, heterocyclyl, or heteroaryl, wherein R 5 is optionally substituted with one or more R 5a , wherein

each R 5a is independently halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, nitro, heterocyclyloxy, aryl, aryloxy, arylalkyl, aryloxyaryl, aryl C 1 -C 6 alkoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-;

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl,

R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —Z, or —Y—Z, wherein

Y is —[C(R 15′ ) 2 ] m — or C 2 -C 6 alkenyl,

wherein each R 15′ is independently H, halogen, or (C 1 -C 6 )alkyl; and

Z is —H, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —C(═N—OH)R 11 , or —C(═S)N(R 11 ) 2 ;

R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

provided that R 2 and R 21 are not simultaneously —H;

R 3 is -L-R 6 , wherein

L is a bond, —X 3 —(CH 2 ) n —X 3 —, —(CH 2 ) m —X 3 —(CH 2 ) n — or —(CH 2 ) 1+w —Y 3 —(CH 2 ) w — wherein

n is 0-6; each w is independently 0-5; and

each X 3 is independently a bond, —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C≡C—, —CO—, —CS—, —CONR 10 —, —C(═N)(R 11 )—, —C(═N—OR 11 )—, —C[═N—N(R 11 ) 2 ], —CO 2 —, —SO 2 —, or —SO 2 N(R 10 )—; and

Y 3 is —O—, —S—, —NR 7 —, —N(R 10 )CO—, —N(R 10 )CO 2 —, —OCO—, —OC(═O)N(R 10 )—, —NR 10 CONR 10 —, —N(R 10 )SO 2 —, or —NR 10 CSNR 10 —;

or L is a C 2-6 alidiyl chain, wherein the alidiyl chain is optionally interrupted by —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C(R 11 ) 2 O—, —C(R 11 ) 2 NR 11 —, —C≡C—, —O—, —S—, —N(R 10 )CO—, —N(R 10 )CO 2 —, —CON(R 10 )—, —CO—, —CO 2 —, —OC(═O)—, —OC(═O)N(R 10 )—, —SO 2 —, —N(R 10 )SO 2 —, or —SO 2 N(R 10 ); and

R 6 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, aryl, C 3 -C 8 cycloalkyl, heteroaryl, heterocyclyl, —CN, —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —N(R 11 ) 2 , —SO 2 R 11 , —S(═O) 2 N(R 11 ) 2 , —C(═O)N(R 11 )N(R 11 ) 2 , or —C(═O)N(R 11 )(OR 11 ), wherein

the aryl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with one or more R 6a , wherein

each R 6a is independently —Z″, —Y″—Z″, or —X″—Y″—Z″, wherein

X″ is —O—;

Y″ is —[C(R 15 ) 2 ] m —, —C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein

the aryl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with at least one group which is each independently Z″;

Z″ is —H, —CN, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —N(R 11 ) 2 , —N 3 , —SO 2 R 11 , —S(═O) 2 N(R 11 ) 2 , —C(═O)N(R 11 )N(R 11 ) 2 , —N(R 11 )C(O)N(R 11 ) 2 , —OC(═O)—OR 11 , —C(═O)N(R 11 )(OR 11 ), —OC(═O)—R 11 , —OC(═O)—N(R 11 ) 2 , or —N(R 11 )COOR 11 ;

each R 10 is independently —R 11 , —C(═O)R 11 , —CO 2 R 11 , or —SO 2 R 11 ;

each R 11 is independently -hydrogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —N(R 12 ) 2 , —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,

wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;

each R 12 is independently hydrogen, halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCN, C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkylNR 13 SO 2 R 13 , —C 0 -C 6 alkyN(R 13 ) 2 , or OC 0 -C 6 alkylCOOR 13 ;

each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;

each R 14 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, C 1 -C 6 haloalkyl, C 0 -C 6 alkylCON(R 11 ) 2 , C 0 -C 6 alkylCONR 11 OR 11 , C 0 -C 6 alkylOR 11 , or C 0 -C 6 alkylCOOR 11 ;

G is a group of the formula:

wherein J is thienyl, K is heteroaryl; and L 2 is a bond;

each R 4 is independently halogen, nitro, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, —C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl, CR 11 ═CR 11 COOR 11 , aryloxy, —S-aryl, aralkyloxy, aryloxyalkyl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkoxyheteroaryl, C 0 -C 6 alkoxyheterocyclyl, aryl, heteroaryl, heterocyclyl, -M, -E-M, or -D-E-M, wherein

D is —O—;

E is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 , COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 4 is optionally substituted with one or more R 4a ,

wherein each R 4a is independently halogen, aryloxy, aralkyloxy, aryloxyalkyl, —C 1 -C 6 alkyl-aryl, C 1 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, -M′, -E′-M′, or -D′-E′-M′

D′ is —O—;

E′ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M′ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, COR 11 , —CON(R 11 ) 2 , —N(R 11 )COOR 11 , —N(R 11 ) 2 , COOR 11 , C≡N, OR 11 , —NR 11 COR 11 , NR 11 SO 2 R 11 , SO 2 R 11 , SO 2 N(R 11 ) 2 , or SR 11 ;

each R 41 is independently halogen, nitro, C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -M″, -E″-M″, or -D″-E″-M″, wherein

D″ is —O—;

E″ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M″ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 41 is optionally substituted with one or more R 4a ;

wherein the aryl, cycloalkyl, heteroaryl, or heterocyclyl is optionally substituted with one or more R 9 , wherein

each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;

each m is independently 0, 1, 2, 3, 4, 5 or 6;

q is 0, 1, 2, 3, 4 or 5; and

q′ is 0, 1, 2, 3, or 4,

(B) provided that,

(i) if the compound is defined by formula Ia, then R 1 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl;

(ii) if the compound is defined by formula Ib, then

(a) R 2 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl; and

(b) R 1 is not 4-hydroxyphenyl;

(iii) if the compound is defined by formula Ic, then R 2 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl;

(iv) if the compound is defined by formula Id, then

(a) if L 1 is a bond, then R 1 is not thienyl or 5-methylthienyl; and

(b) R 1 is not 4-Me-phenyl.

35. The compound according to claim 34 , wherein K is thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, pyridyl, pyrimidinyl, or pyrazinyl.

36. The compound according to claim 35 , wherein K is pyridyl.

37. The compound according to claim 36 , wherein

L 1 is a bond; and

R 5 is phenyl optionally substituted with one or more R 5s .

38. A compound according to one of the following formulas:

or a pharmaceutically acceptable salt thereof, wherein

(A) R 1 is -L 1 -R 5 , wherein

L 1 is a bond, L 5 , or L 6 , wherein L 5 is —[C(R 15 ) 2 ] m —, wherein

each R 15 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, or (C 1 -C 6 )haloalkyl;

L 6 is C 3 -C 8 cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl, wherein the cycloalkyl, cycloC 3-8 haloalkyl, or heterocyclyl are optionally substituted with one or more radicals of R 14 ;

R 5 is aryl, heterocyclyl, or heteroaryl, wherein R 5 is optionally substituted with one or more R 5a , wherein

each R 5a is independently halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, alkenyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, nitro, heterocyclyloxy, aryl, aryloxy, arylalkyl, aryloxyaryl, aryl C 1 -C 6 alkoxy, —C′, —B′—C′, or -A′-B′—C′ wherein

A′ is —O—;

B′ is —[C(R 15 ) 2 ] m — or —C 3 -C 8 cycloalkyl-;

C′ is —H, halogen, —SO 2 R 11 , —OR 11 , —SR 11 , —N 3 , —COR 11 , —SO 2 N(R 11 ) 2 , —SO 2 NR 11 COR 11 , —C≡N, —C(O)OR 11 , —OC(═O)R 11 , —CON(R 11 ) 2 , —CON(R 11 )OR 11 , —OCON(R 11 ) 2 , —NR 11 COR 11 , —NR 11 CON(R 11 ) 2 , —NR 11 COOR 11 , —N(R 11 ) 2 , aryl, heteroaryl, or heterocyclyl,

R 2 is -L 3 -R 7 , wherein

L 3 is a bond; and

R 7 is hydrogen, halogen, —Z, or —Y—Z, wherein

Y is —[C(R 15′ ) 2 ] m — or C 2 -C 6 alkenyl,

wherein each R 15′ is independently H, halogen, or (C 1 -C 6 )alkyl; and

Z is —H, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —C(═N—OH)R 11 , or —C(═S)N(R 11 ) 2 ;

R 21 is hydrogen, halogen, nitro, cyano, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

provided that R 2 and R 21 are not simultaneously —H;

R 3 is -L-R 6 , wherein

L is a bond, —X 3 —(CH 2 ) n —X 3 —, —(CH 2 ) m —X 3 —(CH 2 ) n — or —(CH 2 ) 1+w —Y 3 —(CH 2 ) w — wherein

n is 0-6; each w is independently 0-5; and

each X 3 is independently a bond, —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C≡C—, —CO—, —CS—, —CONR 10 —, —C(═N)(R 11 )—, —C(═N—OR 11 )—, —C[═N—N(R 11 ) 2 ], —CO 2 —, —SO 2 —, or —SO 2 N(R 10 )—; and

Y 3 is —O—, —S—, —NR 7 —, —N(R 10 )CO—, —N(R 10 )CO 2 —, —OCO—, —OC(═O)N(R 10 )—, —NR 10 CONR 10 —, —N(R 10 )SO 2 —, or —NR 10 CSNR 10 —;

or L is a C 2-6 alidiyl chain, wherein the alidiyl chain is optionally interrupted by —C(R 11 ) 2 —, —C(R 11 ) 2 C(R 11 ) 2 —, —C(R 11 )═C(R 11 )—, —C(R 11 ) 2 O—, —C(R 11 ) 2 NR 11 —, —C≡C—, —O—, —S—, —N(R 10 )CO—, —N(R 10 )CO 2 —, —CON(R 10 )—, —CO—, —CO 2 —, —OC(═O)—, —OC(═O)N(R 10 )—, —SO 2 —, —N(R 10 )SO 2 —, or —SO 2 N(R 10 ); and

R 6 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, aryl, C 3 -C 8 cycloalkyl, heteroaryl, heterocyclyl, —CN, —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —N(R 11 ) 2 , —SO 2 R 11 , —S(═O) 2 N(R 11 ) 2 , —C(═O)N(R 11 )N(R 11 ) 2 , or —C(═O)N(R 11 )(OR 11 ), wherein

the aryl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with one or more R 6a , wherein

each R 6a is independently —Z″, —Y″—Z″, or —X″—Y″—Z″, wherein

X″ is —O—;

Y″ is —[C(R 15 ) 2 ] m —, —C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein

the aryl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with at least one group which is each independently Z″;

Z″ is —H, —CN, halogen, —OR 11 , —C(═O)R 11 , —C(═O)OR 11 , —C(═O)N(R 11 ) 2 , —N(R 11 ) 2 , —N 3 , —SO 2 R 11 , —S(═O) 2 N(R 11 ) 2 , —C(═O)N(R 11 )N(R 11 ) 2 , —N(R 11 )C(O)N(R 11 ) 2 , —OC(═O)—OR 11 , —C(═O)N(R 11 )(OR 11 ), —OC(═O)—R 11 , —OC(═O)—N(R 11 ) 2 , or —N(R 11 )COOR 11 ;

each R 10 is independently —R 11 , —C(═O)R 11 , —CO 2 R 11 , or —SO 2 R 11 ;

each R 11 is independently -hydrogen, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-, —N(R 12 ) 2 , —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —C 3 -C 8 cycloalkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, aryl, —(C 1 -C 6 )alkyl-aryl, heteroaryl, —(C 1 -C 6 )alkyl-heteroaryl, heterocyclyl, or —(C 1 -C 6 )alkyl-heterocyclyl,

wherein any of R 11 is optionally substituted with one or more radicals of R 12 ;

each R 12 is independently hydrogen, halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, (C 0 -C 6 alkyl)C═O(OR 13 ); C 0 -C 6 alkylOR 13 , C 0 -C 6 alkylCOR 13 , C 0 -C 6 alkylSO 2 R 13 , C 0 -C 6 alkylCN, C 0 -C 6 alkylCON(R 13 ) 2 , C 0 -C 6 alkylCONR 13 OR 13 , C 0 -C 6 alkylSO 2 N(R 13 ) 2 , C 0 -C 6 alkylSR 13 , C 0 -C 6 haloalkylOR 13 , aryloxy, aralkyloxy, aryloxyalkyl, C 0 -C 6 alkoxyaryl, aryl C 0 -C 6 alkylcarboxy, C 0 -C 6 alkylNR 13 SO 2 R 13 , —C 0 -C 6 alkyN(R 13 ) 2 , or OC 0 -C 6 alkylCOOR 13 ;

each R 13 is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (C 3 -C 8 cycloalkyl)-C 1 -C 6 alkyl-, (C 3 -C 8 cycloalkenyl)-C 1 -C 6 alkyl-, or (C 3 -C 8 cycloalkyl)-C 2 -C 6 alkenyl-;

each R 14 is independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, C 1 -C 6 haloalkyl, C 0 -C 6 alkylCON(R 11 ) 2 , C 0 -C 6 alkylCONR 11 OR 11 , C 0 -C 6 alkylOR 11 , or C 0 -C 6 alkylCOOR 11 ;

G is a group of the formula:

wherein J is thienyl; K is absent; and L 2 is —SO 2 — or —CO—;

each R 4 is independently heterocyclyl, —OR 11 , or —N(R 11 ) 2 ,

wherein the heterocyclyl is optionally substituted with one or more -E′-M′, wherein

E′ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M′ is COR 11 , COOR 11 , C≡N, OR 11 , —NR 11 COR 11 , NR 11 SO 2 R 11 , SO 2 R 11 , SO 2 N(R 11 ) 2 , or SR 11 ,

each R 41 is independently halogen, nitro, C 1 -C 6 alkyl-heterocyclyl, —C 1 -C 6 alkyl-heteroaryl, —C 1 -C 6 alkyl-aryl, -M″, -E″-M″, or -D″-E″-M″, wherein

D″ is —O—;

E″ is —[C(R 15 ) 2 ] m — or C 3 -C 8 cycloalkyl;

M″ is —C 1 -C 6 alkyl, —C 1 -C 6 haloalkyl, —COR 11 , —COOR 11 , —CON(R 11 ) 2 , —C≡N, —OR 11 , —OCON(R 11 ) 2 , —OCO 2 —R 11 , —N 3 , —NR 11 COR 11 , —NR 11 SO 2 R 11 , —N(R 11 ) 2 , —NR 11 COOR 11 , —SOR 11 , —SO 2 R 11 , —SO 2 NR 11 COR 11 , —SO 2 N(R 11 ) 2 , or —SR 11 ,

wherein each R 41 is optionally substituted with one or more R 4a ;

wherein the aryl, cycloalkyl, heteroaryl, or heterocyclyl is optionally substituted with one or more R 9 , wherein

each R 9 is independently halogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, C 1 -C 6 alkyloxy, C 0 -C 6 alkyl or C 1 -C 6 alkylCOOR 11 ;

each m is independently 0, 1, 2, 3, 4, 5 or 6;

q is 1; and

q′ is 0, 1, 2, 3, or 4,

(B) provided that,

(i) R 4 is bonded directly to L 2 ;

(ii) if L 2 is SO 2 , then R 5 is substituted with at least one R 5a ;

(iii) if the compound is defined by formula Ia, then R 1 is not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )phenyl, or 4-(CH 2 FSO 2 )phenyl;

(iv) if the compound is defined by formula Ib, then

(a) R 2 and R 3 are not 4-(NH 2 SO 2 )-phenyl, 4-(CH 3 SO 2 )-phenyl, or 4-(CH 2 FSO 2 )phenyl; and

(b) R 1 is not 4-hydroxyphenyl;

(v) if the compound is defined by formula Ic, then R 2 and R 3 are not 4-(NH 2 SO 2 )phenyl, 4-(CH 3 SO 2 )-phenyl, or 4-(CH 2 FSO 2 )phenyl;

(vi) if the compound is defined by formula Id, then

(a) if L 1 is a bond, then R 1 is not thienyl or 5-methylthienyl; and

(b) R 1 is not 4-Me-phenyl.

39. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier.

40. A compound selected from the group consisting of

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3-fluoro-2-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-1-(3-fluoro-2-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,3-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-(difluoromethoxy)phenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-(trifluoromethyl)phenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,6-dimethylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-fluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,6-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-chloro-6-fluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-chloro-6-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,4-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chlorophenyl)-5-(4-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(4-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(4-bromo-3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chlorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chlorophenyl)-5-(3-methyl-4-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(4-methylpyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2,6-dimethylpyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-(trifluoromethyl)phenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-fluoro-2-methylphenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chloro-3-fluorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-chloro-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chloro-3-fluorophenyl)-5-(3-chloro-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-chloro-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-fluoro-2-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chloro-3-fluorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-fluoro-2-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)propan-2-ol;

3-(5-(1-(2-chlorophenyl)-3-(2-hydroxypropan-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)-N-(2-(dimethylamino)ethyl)benzenesulfonamide;

2-(1-(6-methyl-4-(trifluoromethyl)-1,6-dihydropyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-methylphenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrazole;

2-(1-(5-fluoropyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazol-1-yl)-3-(trifluoromethyl)pyridine;

2-(1-(2-chlorophenyl)-5-(3-ethyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chloro-3-fluorophenyl)-5-(3-ethyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

3-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazol-1-yl)-4-(trifluoromethyl)pyridine;

2-(5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(5-fluoropyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-1-(5-fluoropyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-(1H-imidazol-1-yl)ethyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazole;

2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-(trifluoromethyl)pyridin-4-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-methyl-4-(2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethyl)piperazine;

1-(2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethyl)pyrrolidin-3-ol;

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-(trifluoromethyl)pyridin-4-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3-fluoropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-chloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazole;

2-(4-chloro-1-(3-chloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3,5-dichloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3,5-dichloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-3-(2-methoxypropan-2-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazole;

2-(1-(2,6-dichlorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-{2-[(2,2-dimethylpropyl)oxy]phenyl}-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2,5-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-{2-[(2-methylpropyl)oxy]phenyl}-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-[2-(ethyloxy)phenyl]-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-{2-[(1-methylethyl)oxy]phenyl}-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl 2-methylpropanoate;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-(trifluoromethyl)pyridine;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl dimethylcarbamate;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

2-(ethylsulfonyl)-3-methyl-5-(5-{3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-2-thienyl)pyridine;

2-(ethylthio)-3-methyl-5-(5-{3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-2-thienyl)pyridine;

1-(2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}pyridine;

2-methyl-4-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole;

4-{2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethyl}morpholine;

5-methyl-3-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl} isoxazole;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoic acid;

1-(2,4-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2,3-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

5-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}furan-2-carboxylic acid;

4-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}benzoic acid;

1-(2,5-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-[(5-chloro-2-thienyl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-[2-(methyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

(3-{5-[1-[(5-chloro-2-thienyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetic acid;

1-[(2,4-difluorophenyl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(phenylmethyl)-3-(trifluoromethyl)-1H-pyrazole;

1-(2,5-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

(3-{5-[1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetic acid;

2-(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)-2-methylpropanoic acid;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]thiophene-2-carboxylic acid;

3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

1-[5-chloro-2-(methyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

5-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methyl-2-(methylthio)pyridine;

5-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methyl-2-(methylsulfonyl)pyridine;

3-methyl-2-(methylthio)-5-(5-{3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-2-thienyl)pyridine;

5-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}-3-methyl-2-(methylthio)pyridine;

3-methyl-2-(methylsulfonyl)-5-(5-{3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-2-thienyl)pyridine;

5-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}-3-methyl-2-(methylsulfonyl)pyridine;

1-(2,5-dichlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

methyl (3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}phenyl)acetate;

methyl (3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}-5-ethylphenyl)acetate;

(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}phenyl)acetic acid;

2-(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}phenyl)-2-methylpropanoic acid;

1-[2-(methyloxy)phenyl]-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol;

2-methyl-4-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole;

2-methyl-4-{[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole;

2-(3-ethyl-5-{5-[1-[2-(methyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}phenyl)-2-methylpropanoic acid;

5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(2-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl methylcarbamate;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl propylcarbamate;

methyl 1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylate;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylic acid;

1-[3-(methyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

N-(3-{5-[1-(2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)methanesulfonamide;

2-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-4-fluorophenol;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl 2,2-dimethylpropanoate;

3-methyl-5-{5-[1-[2-(methyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}-2-(methylsulfonyl)pyridine;

5-{5-[1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methyl-2-(methylsulfonyl)pyridine;

N-{2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

1-(2-chlorophenyl)-5-{5-[3-(ethylsulfonyl)-5-(1-methylethyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-pyridin-2-yl-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-pyridin-3-yl-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-pyridin-4-yl-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(dimethylamino)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(methyloxy)propyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-[2-chloro-5-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-[2-chloro-5-(methyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(5-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methyl-2-(methylthio)pyridine;

1-(2-chloro-5-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(ethylthio)-3-methylpyridine;

5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methyl-2-(methylsulfonyl)pyridine;

5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(ethylsulfonyl)-3-methylpyridine;

3-chloro-2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine;

2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl (1-methylethyl)carbamate;

4-(2-chlorophenyl)-1-methyl-3-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole;

4-[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)carbonyl]morpholine;

1-(2-chlorophenyl)-N-[6-(methyloxy)pyridin-3-yl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-[5-chloro-2-(phenyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

3-methyl-5-{5-[1-[2-(methyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}-2-(methylthio)pyridine;

4-chloro-3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol;

1-[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)carbonyl]piperidine;

1-[2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethyl]piperidine;

4-[2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethyl]morpholine;

1-(2-chlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2-chlorophenyl)-N,N-dimethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

4-chloro-3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzamide;

4-(2-chlorophenyl)-1-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole;

4-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)morpholine;

1-(2-bromophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1,1-dimethylethyl 4-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)piperazine-1-carboxylate;

(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetic acid;

(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetic acid;

2-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)-2-methylpropanoic acid;

1-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)piperazine;

1-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)piperazine;

1-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)piperazine;

methyl (5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-3-yl)acetate;

methyl (4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methylphenyl)acetate;

5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(2-propylphenyl)-3-(trifluoromethyl)-1H-pyrazole;

1-[2-(1-methylethyl)phenyl]-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-[(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)oxy]-2-methylpropanoic acid;

1-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)cyclobutanecarboxylic acid;

2-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)-2-ethylbutanoic acid;

2-(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)-2-methylpropanoic acid;

(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-4-fluorophenyl)acetic acid;

methyl (3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-4-fluorophenyl)acetate;

(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-3-methylphenyl)acetic acid;

1-[3-(ethyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

1-{3-[(2-methylpropyl)oxy]phenyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}benzenesulfonamide;

3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3-thienyl}benzenesulfonamide;

({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetic acid;

1,1-dimethylethyl ({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetate;

N,N-diethyl-2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethanamine;

({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetic acid;

methyl 2-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-3-yl)-2-methylpropanoate;

4-(2-{[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)methyl]oxy}ethyl)morpholine;

1,1-dimethylethyl 2-methyl-2-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)propanoate;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl dimethylcarbamate;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl methylcarbamate;

4-{2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}morpholine;

2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethanol;

4-(2-chlorophenyl)-3-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(2,2,2-trifluoroethyl)-1H-pyrazole;

1-(2-chlorophenyl)-3-(trifluoromethyl)-5-{4-[3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazole;

1-methyl-4-{2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}piperazine;

1-{2-[(3-chloropropyl)oxy]phenyl}-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

3-{5-[1-(2-chloro-5-hydroxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)methanol;

3-(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)propanoic acid;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl diethylcarbamate;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl propylcarbamate;

N-{3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}acetamide;

methyl (1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)acetate;

1-[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)carbonyl]piperidine;

3-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)propanoic acid;

2-[({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)methyl]pyridine;

methyl 5-{5-[3-(aminosulfonyl)phenyl]-2-thienyl}-1-(2,5-dichlorophenyl)-1H-pyrazole-3-carboxylate;

ethyl 4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)benzoate;

4-[3-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)propyl]morpholine;

1-methyl-4-[3-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)propyl]piperazine;

1-methylethyl 5-{5-[3-(aminosulfonyl)phenyl]-2-thienyl}-1-(2,5-dichlorophenyl)-1H-pyrazole-3-carboxylate;

N,N-dimethyl-2-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetamide;

4-[({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetyl]morpholine;

3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline;

4-[2-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethyl]morpholine;

N,N-dimethyl-2-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethanamine;

1-[2-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethyl]piperidine;

4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoic acid;

3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoic acid;

(2E)-3-(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)prop-2-enoic acid;

4-chloro-2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol;

3-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)benzenesulfonamide;

1-{5-chloro-2-[(4-fluorophenyl)oxy]phenyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-2-yl)piperazine;

4-({3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)piperidine;

2-(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-3-yl)-2-methylpropanoic acid;

(5-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}pyridin-3-yl)acetic acid;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[3-(phenyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-[({[5-(trifluoromethyl)furan-2-yl]methyl}oxy)methyl]-1H-pyrazole;

2-({[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)methyl]oxy}methyl)pyridine;

1-({5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}sulfonyl)-4-methylpiperazine;

1-({5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}sulfonyl)piperidine;

4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)benzoic acid;

3-(5-{3-(trifluoromethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-2-thienyl)benzenesulfonamide;

N-[(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)sulfonyl]acetamide;

1-(2,5-dichlorophenyl)-5-(5-{3-[(1,1-dimethylethyl)sulfonyl]phenyl}-2-thienyl)-3-(trifluoromethyl)-1H-pyrazole;

1-(2,5-dichlorophenyl)-5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-3-(trifluoromethyl)-1H-pyrazole;

2-(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)-N-ethylacetamide;

2-(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

1-(2,5-dichlorophenyl)-5-{5-[3-(ethylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

1-(2,5-dichlorophenyl)-5-{5-[3-(propylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]methanol;

5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]thiophene-2-sulfonic acid;

methyl 1-[(1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)carbonyl]piperidine-4-carboxylate;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-piperidin-1-yl-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-methylpiperazine;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(dimethylamino)propyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

methyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N-methylglycinate;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-morpholin-4-ylethyl)-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N,N-dimethylpiperidin-4-amine;

1-(1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazole-3-carbonyl)piperidine-4-carboxylic acid;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(4-pyrrolidin-1-ylbutyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[(2S)-2-hydroxypropyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

N-{2-[bis(1-methylethyl)amino]ethyl}-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidine-3-carboxamide;

1-(2-chlorophenyl)-N-ethyl-N-(2-hydroxyethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

ethyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}serinate;

ethyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-L-serinate;

1-acetyl-4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazine;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-[1-(2-methyl-1,3-thiazol-4-yl)ethyl]-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(4-methylpyrimidin-2-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

ethyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-beta-alaninate;

1-(2-chlorophenyl)-N-(1,3-dioxolan-2-ylmethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(3-thienylmethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)ethyl]-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-1H-pyrazol-3-yl-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-{2-(dimethylamino)-2-[4-(methyloxy)phenyl]ethyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

ethyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N-(furan-2-ylmethyl)-beta-alaninate;

4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-2,6-dimethylmorpholine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidin-3-ol;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-oxotetrahydro-3-thienyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(3-morpholin-4-ylpropyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(2-cyanoethyl)-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(4-fluorophenyl)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-piperidin-1-ylethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(pyridin-4-ylmethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-pyridin-2-ylethyl)-1H-pyrazole-3-carboxamide;

3-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4,4-dimethyl-1,3-oxazolidine;

3-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}amino)-2-methylpropanoic acid;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-methyl-1,4-diazepane;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidin-4-ol;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidine-2-carboxylic acid;

1-(2-chlorophenyl)-N-[2-(1H-imidazol-4-yl)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(pyridin-3-ylmethyl)-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-ethylpiperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-1,4-diazepane;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-pyrrolidin-1-ylethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-{[4-(methyloxy)phenyl]methyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-{[3-(trifluoromethyl)phenyl]methyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-[2-(2-thienyl)ethyl]-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(2-methylpiperidin-1-yl)propyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazole-3-carboxamide;

N-{[3,4-bis(methyloxy)phenyl]methyl}-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-{[2-(methyloxy)phenyl]methyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-{[3-(methyloxy)phenyl]methyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-pyridin-2-ylethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-{2-[2-(methyloxy)phenyl]ethyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(furan-2-ylmethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(dimethylamino)-2,2-dimethylpropyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

ethyl 1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidine-2-carboxylate;

1-(2-chlorophenyl)-N-[3-(dimethylamino)propyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

8-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane;

3-(4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-1-yl)-N,N-dimethylpropan-1-amine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-[3-(methyloxy)propyl]piperazine;

ethyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N-methylglycinate;

1-(2-chlorophenyl)-N-{3-[(1-methylethyl)oxy]propyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

4-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}amino)butanoic acid;

N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N,2-dimethylalanine;

[(2S)-1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}pyrrolidin-2-yl]methanol;

1-(2-chlorophenyl)-N-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylmethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[(5-methylpyrazin-2-yl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(5-hydroxypentyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

(4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-1-yl)acetic acid;

1-(2-chlorophenyl)-N-[2-(dimethylamino)ethyl]-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(dimethylamino)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(phenylmethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(2-hydroxyethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(1,3-dioxolan-2-ylmethyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-(1-ethylpropyl)piperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-[2-(methyloxy)ethyl]piperazine;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-pyridin-4-yl-1H-pyrazole-3-carboxamide;

4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-2-one;

1-(2-chlorophenyl)-N-(5-methyl-1,3,4-oxadiazol-2-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidine-3-carboxylic acid;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}azetidine-3-carboxylic acid;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(pyridin-4-ylmethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(1-methyl-1H-pyrazol-3-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-pyridin-2-yl-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-[4-(methyloxy)butyl]piperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-hexylpiperazine;

N-[2-(4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-1-yl)ethyl]-N-prop-2-en-1-ylprop-2-en-1-amine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-(1-methylpropyl)piperazine;

1-(2-chlorophenyl)-N-methyl-N-(1-methylpiperidin-4-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

N-[2-(4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-1-yl)ethyl]-N-propylpropan-1-amine;

1-(2-chlorophenyl)-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-(1-methylethyl)piperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-pentylpiperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-heptylpiperazine;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-(1-methylbutyl)piperazine;

N-(2-amino-2-oxoethyl)-1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-1,2-dimethylpiperazine;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N,N-bis(pyridin-2-ylmethyl)-1H-pyrazole-3-carboxamide;

ethyl 1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidine-4-carboxylate;

ethyl 4-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}amino)piperidine-1-carboxylate;

(3R)-1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N,N-dimethylpyrrolidin-3-amine;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(3-pyrrolidin-1-ylpropyl)-1H-pyrazole-3-carboxamide;

2,2′-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}imino)diacetic acid;

N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-D-serine;

2-(4-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperazin-1-yl)ethanol;

1-(2-chlorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[(1-ethylpyrrolidin-3-yl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(2-methyl-2-morpholin-4-ylpropyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

N-(2-amino-2-methylpropyl)-1-(2-chlorophenyl)-N-(2-hydroxy-1,1-dimethylethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-methyl-N-{[1-(1-methylethyl)pyrrolidin-3-yl]methyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-propylpiperazine;

1-(2-chlorophenyl)-N-(3-hydroxypropyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-(2-hydroxyethyl)-N-[2-(methyloxy)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

(3R)-1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}pyrrolidin-3-ol;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N,N-diethylpyrrolidin-3-amine;

1-(2-chlorophenyl)-N-[4-(diethylamino)-1-methylbutyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

N-{[4-(aminosulfonyl)phenyl]methyl}-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(1,3-dioxolan-2-yl)ethyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

(1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}piperidin-3-yl)methanol;

1-(3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)ethanone;

2-[1-(2-chlorophenyl)-5-{5-[4-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[3,4-bis(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-chloro-4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-(1-methylethyl)benzamide;

2-[1-(2-chlorophenyl)-5-{5-[2-(methylthio)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2-fluorobiphenyl-4-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(3-fluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

N-(3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetamide;

2-[1-(2-chlorophenyl)-5-(5-{4-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-fluoro-3-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(4-chlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[5-fluoro-2-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(ethyloxy)-3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,3-dichlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-pyrimidin-5-yl-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoic acid;

N-(4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)methanesulfonamide;

2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-fluorophenol;

2-[1-(2-chlorophenyl)-5-(5-{4-fluoro-2-[(phenylmethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-fluorobenzoic acid;

2-{1-(2-chlorophenyl)-5-[5-(1-methyl-1H-indol-5-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{2-[(1-methylethyl)oxy]-5-(trifluoromethyl)phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-chloro-5-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzamide;

2-{5-[5-(2-chloro-6-fluorophenyl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N,N-dimethylbenzenesulfonamide;

2-chloro-4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-methylbenzamide;

2-[1-(2-chlorophenyl)-5-(5-{2-methyl-4-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-(furan-2-ylmethyl)benzamide;

methyl 2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoate;

2-[5-{5-[3-chloro-4-(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(1,3-thiazolidin-3-ylcarbonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-chloro-4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-cyclopropylbenzamide;

2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-4-fluorophenol;

N-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)methanesulfonamide;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-fluorobenzoic acid;

2-[1-(2-chlorophenyl)-5-{5-[4-(methylthio)-3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-methyl-5-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(methyloxy)pyridin-3-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[6-(methyloxy)pyridin-3-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(methyloxy)-3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-pyridin-3-yl-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(1H-indol-6-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[(1E)-3,3-dimethylbut-1-en-1-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

1,1-dimethylethyl 2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-1H-pyrrole-1-carboxylate;

2-[1-(2-chlorophenyl)-5-(5-{2-[(1-methylethyl)oxy]pyridin-3-yl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(cyclopentyloxy)pyridin-3-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

ethyl 4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoate;

2-{1-(2-chlorophenyl)-5-[5-(5-methylfuran-2-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzamide;

methyl N-[(4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)carbonyl]glycinate;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzamide;

2-[1-(2-chlorophenyl)-5-{5-[3-(thiomorpholin-4-ylcarbonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{5-[5-(1,3-benzodioxol-5-yl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-methyl-5-(morpholin-4-ylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[2,4-bis(trifluoromethyl)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[2,3-bis(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3,5-difluoro-2-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(phenyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(3,5-dichlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,4,5-trimethylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-naphthalen-2-yl-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{2-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-fluoro-5-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[(1E)-prop-1-en-1-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(5-fluoro-2-methylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(hydroxymethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{5-methyl-2-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-(2,2′-bithien-5-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-(5-biphenyl-3-yl-2-thienyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[5-methyl-2-(propyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(4-propylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{4-[(trifluoromethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-(2-methylpropyl)benzamide;

2-[1-(2-chlorophenyl)-5-{5-[3-(ethyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(4-ethylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(3,4-dichlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[6-(methyloxy)naphthalen-2-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2-ethylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(dimethylamino)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,4,5-trifluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-fluoro-5-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,3,4-trifluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

N-(4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetamide;

2-[1-(2-chlorophenyl)-5-{5-[3-(hydroxymethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[5-chloro-2-(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2,3,4-tris(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(1H-indol-5-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[6-(ethyloxy)naphthalen-2-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(hydroxymethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,3-difluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,4-difluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{5-[5-(2-chloro-6-fluoro-3-methylphenyl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(methylthio)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{5-[5-(6-chloro-2-fluoro-3-methylphenyl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(4-fluoro-3-methylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(3,4-difluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol

2-[1-(2-chlorophenyl)-5-{5-[4-(phenyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-chloro-2-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,5-dichlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[5-{5-[2-chloro-4-(ethyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(3-chlorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(1H-indol-4-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-chloro-4-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

N-(3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)methanesulfonamide;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-(1-methylethyl)benzamide;

2-[1-(2-chlorophenyl)-5-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[3,5-bis(trifluoromethyl)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-(5-biphenyl-4-yl-2-thienyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(1-methylethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-ethyl-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-chloro-4-(trifluoromethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(ethylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenol;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoic acid;

2-{1-(2-chlorophenyl)-5-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2-fluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{3-[(1-methylethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

1-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)ethanone;

2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenol;

1-(4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)ethanone;

2-[1-(2-chlorophenyl)-5-{5-[5-methyl-2-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl 1,1-dimethylethyl carbonate;

2-[5-{5-[2-chloro-6-(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(1-methyl-1H-pyrazol-4-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

4-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}ethyl)benzoic acid;

2-[1-(2-chlorophenyl)-5-{5-[(1E)-1-ethylbut-1-en-1-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(ethylthio)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzonitrile;

2-[1-(2-chlorophenyl)-5-{5-[3-fluoro-4-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2,5-difluorophenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(ethyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{5-[5-(1-benzothien-3-yl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

ethyl 2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzoate;

2-[1-(2-chlorophenyl)-5-{5-[(E)-2-(4-fluorophenyl)ethenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(4-ethenylphenyl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{1-(2-chlorophenyl)-5-[5-(2-chloropyridin-4-yl)-2-thienyl]-1H-pyrazol-3-yl}propan-2-ol;

2-{5-[5-(3-chloro-4-fluorophenyl)-2-thienyl]-1-(2-chlorophenyl)-1H-pyrazol-3-yl}propan-2-ol;

1-{5′-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2,2′-bithien-5-yl}ethanone;

2-[1-(2-chlorophenyl)-5-{5-[4-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzaldehyde;

2-[5-{5-[2,5-bis(methyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-naphthalen-1-yl-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-(5-biphenyl-2-yl-2-thienyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[5-chloro-2-(ethyloxy)phenyl]-2-thienyl}-1-(2-chlorophenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[2-(ethylthio)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-2,6-dimethylphenol;

2-[1-(2-chlorophenyl)-5-{5-[2-(1-methylethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[4-(ethyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[1-(phenylmethyl)-1H-pyrazol-4-yl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

1,1-dimethylethyl (2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)carbamate;

2-[1-(2-chlorophenyl)-5-(5-{(E)-2-[4-(methyloxy)phenyl]ethenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

N-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)acetamide;

2-[1-(2-chlorophenyl)-5-{5-[(E)-2-(4-methylphenyl)ethenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

methyl (2E)-3-(4-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)prop-2-enoate;

2-[1-(2-chlorophenyl)-5-{5-[4-fluoro-2-(methyloxy)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}-N-ethylbenzamide;

methyl (2E)-3-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)prop-2-enoate;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(pyrrolidin-1-ylcarbonyl)-1H-pyrazole;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-methylpiperidine;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[2-(dimethylamino)ethyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(dimethylamino)propyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-[(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)sulfonyl]butan-2-ol;

[2-(methylsulfonyl)-4-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]methanol;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone;

[4-fluoro-3-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]acetic acid;

methyl [3-methyl-4-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]acetate;

N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N-methylglycine;

[3-methyl-4-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]acetic acid;

methyl 5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylate;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide;

2-methyl-2-[3-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]propanoic acid;

2-[3-(5-{1-[(5-chloro-2-thienyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)phenyl]-2-methylpropanoic acid;

2-[5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-(trifluoromethyl)pyridine;

methyl 545-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-3-carboxylate;

N-[(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)sulfonyl]-2,2-dimethylpropanamide;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-1-one;

3-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]pentan-3-ol;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-1-ol;

(1E)-1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone oxime;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl)propan-2-ol;

1-{5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl}ethanone;

2-{5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl}propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

methyl 3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate;

2-{3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propan-2-ol;

3-[1-methyl-1-(methyloxy)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

5-{5-[3-(ethylsulfonyl)phenyl]-2-thienyl}-3-[1-methyl-1-(methyloxy)ethyl]-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid;

1-(2-chlorophenyl)-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carbothioamide;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide;

3-(5-{1-[5-chloro-2-(phenyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)benzenesulfonamide;

2-[3-(5-{1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)phenyl]-2-methylpropanoic acid;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(pyrrolidin-1-ylcarbonyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

3-[difluoro(methyloxy)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

2-(1-[5-chloro-2-(phenyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

1-(1-[5-chloro-2-(phenyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)ethanone;

3-{5-[1-(2,5-dichlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(phenyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole;

3-{5-[3-acetyl-1-(2,5-dichlorophenyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

methyl 1-{3-[(methyloxy)carbonyl]phenyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylate;

2-{3-[3-(1-hydroxy-1-methylethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-1-yl]phenyl}propan-2-ol;

1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-{2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propan-2-ol;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2-pyridin-2-ylethyl)-1H-pyrazole-3-carboxamide;

methyl 1-(2-chlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]furan-2-yl}-1H-pyrazole-3-carboxylate;

2-[1-(2-chlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]furan-2-yl}-1H-pyrazol-3-yl]propan-2-ol;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-3-carboxamide;

methyl 1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylate;

2-[1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)propan-2-ol;

2-(4-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)propan-2-ol;

1-[1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone;

2-(1-[(2,4-difluorophenyl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenol;

2-[1-(2-chlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-chloro-6-methyl-3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol;

2-[3-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]propan-2-ol;

2-[4-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]propan-2-ol;

1-[5-(5-{1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)pyridin-2-yl]piperazine;

2-{[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]oxy}ethanol;

2-[1-(3-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(4-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

4-(2-{[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]oxy}ethyl)morpholine;

5-(2-{[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]oxy}ethyl)-1H-tetrazole;

2-[1-(2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-phenyl-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(4-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-pyridin-2-yl-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2,4-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3,5-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3,4-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

1-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-phenyl-1H-pyrazol-3-yl)ethanone;

3-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}benzonitrile;

1-(2-chlorophenyl)-N-(2-hydroxy-1-methylethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(pyridin-3-ylmethyl)-1H-pyrazole-3-carboxamide;

2-[1-(3-fluoropyridin-2-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chloropyridin-3-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-(5-{3-[(trifluoromethyl)oxy]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

methyl 3-{5-[1-(2-chlorophenyl)-3-{[(2,2,2-trifluoroethyl)amino]carbonyl}-1H-pyrazol-5-yl]-2-thienyl}benzoate;

1-(2-chlorophenyl)-5-{5-[3-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carbothioamide;

2-[4-bromo-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,5-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,4-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,3-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-4-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(ethylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]-2-methylpropanoic acid;

ethyl 3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)benzoate;

2-[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]propan-2-ol;

2-[3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[1-(2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

4-bromo-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-[1-(2,5-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,3-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(ethylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[3-{5-[1-(2,6-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[1-(2-chlorophenyl)-4-fluoro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-bromophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

ethyl 1-(2-fluorophenyl)-2-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrrole-3-carboxylate;

2-[1-(2,5-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3,5-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3,4-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,6-dichloro-3-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,3-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(3-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(2-propylphenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(5-fluoro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-5-{5-[3-(1-methylethyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2-fluoro-3-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-chloro-5-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chloro-6-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(5-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[3-(1-hydroxy-1-methylethyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-1-yl]-6-(trifluoromethyl)phenol;

2-[4-bromo-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3-chloro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2,2-difluoro-1,3-benzodioxol-4-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-pyridin-4-yl-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-chloro-6-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2-(1-methylethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-pyridin-3-yl-1H-pyrazol-3-yl)propan-2-ol;

2-(1-[2-chloro-5-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[4-chloro-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[4-(trifluoromethyl)pyridin-3-yl]-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2,6-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2-fluoro-6-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[4-bromo-1-(3-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-bromo-1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[4-bromo-1-(2-bromophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3-fluoro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(3-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-bromophenyl)-4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[4-(trifluoromethyl)pyridin-3-yl]-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-bromo-1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-(2-chlorophenyl)-5-(1-methyl-5-(3-(methylsulfonyl)phenyl)-1H-pyrrol-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-chlorophenyl)-5-(1-methyl-5-(3-(methylsulfonyl)phenyl)-1H-pyrrol-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2,6-dichlorophenyl)-5-(1-methyl-5-(3-(methylsulfonyl)phenyl)-1H-pyrrol-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-3-(2-hydroxypropan-2-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-1-yl)-6-(trifluoromethyl)phenol;

5-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]methyl}oxy)-2-methylpyridine;

3-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]methyl}oxy)-2-methylpyridine;

3-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]methyl}oxy)pyridine;

3-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]methyl}oxy)-2,6-dimethylpyridine;

4-({[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]methyl}oxy)pyridine;

N,N-diethyl-2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetamide;

4-[({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)methyl]pyridine;

N-(1-methylethyl)-2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)acetamide;

5-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)pentanenitrile;

2-[2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)ethyl]-1H-isoindole-1,3(2H)-dione;

2-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)-N-phenylacetamide;

2-[({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)methyl]pyridine;

6-({2-[5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}oxy)hexan-2-one;

1-(2-{5-[1-(2-chlorophenyl)-3-(1-hydroxy-1-methylethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)ethanone; and

1-(2-ethylphenyl)-5-{4-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

or a pharmaceutically acceptable salt thereof.

41. A compound selected from the group consisting of:

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3-fluoro-2-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-1-(3-fluoro-2-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,3-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-(difluoromethoxy)phenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-(trifluoromethyl)phenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,6-dimethylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-fluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,6-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-chloro-6-fluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2-chloro-6-methylphenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(2,4-difluorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chlorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chlorophenyl)-5-(3-methyl-4-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-(trifluoromethyl)phenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-fluoro-2-methylphenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chloro-3-fluorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chloro-3-fluorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-bromo-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-fluoro-2-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3-fluoro-2-methylphenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrazole;

2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazol-1-yl)-3-(trifluoromethyl)pyridine;

2-(1-(2-chlorophenyl)-5-(3-ethyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(2-chloro-3-fluorophenyl)-5-(3-ethyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

3-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazol-1-yl)-4-(trifluoromethyl)pyridine;

2-(5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(4-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-bromo-1-(5-fluoropyridin-3-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(2-(trifluoromethyl)pyridin-3-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1-(3-(trifluoromethyl)pyridin-4-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3-fluoropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(prop-1-en-2-yl)-1H-pyrazole;

2-(4-chloro-1-(3-chloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(1-(3,5-dichloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-1-(3,5-dichloropyridin-4-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-3-(2-methoxypropan-2-yl)-5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazole;

2-(1-(2,6-dichlorophenyl)-5-(3-methyl-5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(dimethylamino)propyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

methyl N-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-N-methylglycinate;

1-(2-chlorophenyl)-N-methyl-N-(1-methylpiperidin-4-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(3-pyrrolidin-1-ylpropyl)-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(pyrrolidin-1-ylcarbonyl)-1H-pyrazole;

1-{[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]carbonyl}-4-methylpiperidine;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;

1-(2-chlorophenyl)-N-[2-(diethylamino)ethyl]-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-(2-chlorophenyl)-N-[3-(dimethylamino)propyl]-N-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxamide;

1-[(3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)sulfonyl]butan-2-ol;

[2-(methylsulfonyl)-4-(5-{3-(trifluoromethyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}-2-thienyl)phenyl]methanol;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide;

2-[3-(5-{1-[(5-chloro-2-thienyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)phenyl]-2-methylpropanoic acid;

2-[5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-(trifluoromethyl)pyridine;

methyl 545-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-3-carboxylate;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-1-one;

3-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]pentan-3-ol;

1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-1-ol;

(1E)-1-[1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone oxime;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl)propan-2-ol;

1-{5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1-[3-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-3-yl}ethanone;

2-[1-(2-chlorophenyl)-5-(5-{3-[(1-methylethyl)sulfonyl]phenyl}-2-thienyl)-1H-pyrazol-3-yl]propan-2-ol;

methyl 3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzoate;

2-{3-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propan-2-ol;

3-[1-methyl-1-(methyloxy)ethyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

5-{5-[3-(ethylsulfonyl)phenyl]-2-thienyl}-3-[1-methyl-1-(methyloxy)ethyl]-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

1-(2-chlorophenyl)-N-ethyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carbothioamide;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxamide;

3-(5-{1-[5-chloro-2-(phenyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)benzenesulfonamide;

2-[3-(5-{1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)phenyl]-2-methylpropanoic acid;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(pyrrolidin-1-ylcarbonyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

3-[difluoro(methyloxy)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole;

2-(1-[5-chloro-2-(phenyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

1-(1-[5-chloro-2-(phenyloxy)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)ethanone;

5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(phenyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole;

3-{5-[3-acetyl-1-(2,5-dichlorophenyl)-1H-pyrazol-5-yl]-2-thienyl}benzenesulfonamide;

methyl 1-{3-[(methyloxy)carbonyl]phenyl}-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylate;

1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-{2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propan-2-ol;

methyl 1-(2-chlorophenyl)-5-{4-[3-(methylsulfonyl)phenyl]furan-2-yl}-1H-pyrazole-3-carboxylate;

methyl 1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazole-3-carboxylate;

2-[1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}phenyl)propan-2-ol;

1-[1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]ethanone;

2-(1-[(2,4-difluorophenyl)methyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

1-[5-(5-{1-[(2,4-difluorophenyl)methyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl}-2-thienyl)pyridin-2-yl]piperazine;

2-[1-(2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-phenyl-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2,4-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

1-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-phenyl-1H-pyrazol-3-yl)ethanone;

2-[1-(2-chloropyridin-3-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-N-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carbothioamide;

2-[4-bromo-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-chlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chlorophenyl)-4-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-2-(methylsulfonyl)phenyl]propan-2-ol;

2-[3-{5-[1-(2,5-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[1-(2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

4-bromo-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-3-(trifluoromethyl)-1H-pyrazole;

2-[1-(2,5-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,3-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[3-{5-[1-(2,6-dichlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[3-{5-[1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}-5-(methylsulfonyl)phenyl]propan-2-ol;

2-[1-(2-chlorophenyl)-4-fluoro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-bromophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

ethyl 1-(2-fluorophenyl)-2-methyl-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrrole-3-carboxylate;

2-[1-(2,6-dichloro-3-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,3-difluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(3-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-(2-propylphenyl)-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(5-fluoro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chloro-5-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chloro-6-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(5-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-bromo-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3-chloro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2,2-difluoro-1,3-benzodioxol-4-yl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(2-chloro-6-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2-(1-methylethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-(5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-pyridin-3-yl-1H-pyrazol-3-yl)propan-2-ol;

2-[4-chloro-1-(2,6-dichlorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

2-(4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[2-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2,6-dimethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(1-[2-fluoro-6-(trifluoromethyl)phenyl]-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[4-bromo-1-(3-chloro-2-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-bromo-1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[4-bromo-1-(2-bromophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[1-(3-fluoro-2-methylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-{2-[(trifluoromethyl)oxy]phenyl}-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-bromophenyl)-4-chloro-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-(4-bromo-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1-[4-(trifluoromethyl)pyridin-3-yl]-1H-pyrazol-3-yl)propan-2-ol;

2-[1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-bromo-1-(2-chloro-3-fluorophenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol;

2-[4-chloro-1-(2-ethylphenyl)-5-{5-[3-(methylsulfonyl)phenyl]-2-thienyl}-1H-pyrazol-3-yl]propan-2-ol; and

2-(1-(2-chlorophenyl)-5-(1-methyl-5-(3-(methylsulfonyl)phenyl)-1H-pyrrol-2-yl)-1H-pyrazol-3-yl)propan-2-ol;

or a pharmaceutically acceptable salt thereof.