Stable water soluble composition containing lysophosphatidylethanolamine and lecithin
View Patent ↗The invention relates to a stable water soluble composition containing lithophosphatidylethanol amine (LPE) or lecithin including the LPE 3% or more. The composition comprises one or both of lysophosphatidylethanol amine and lecithin 0.1 to 50 wt %, fatty acid or salt thereof 0.1 to 60 wt % and solvent 10 to 99.8 wt %. According to the invention, it is possible to provide the stable water soluble composition of lithophosphatidylethanolamine and lecithin which does not cause the precipitation at the room temperature below 20° C. and can maintain the clear formulation even during the long term keeping.
1. A water soluble composition containing lysophosphatidylethanolamine or lecithin, comprising:
0.1 to 50 wt % of one or both of water-soluble lysophosphatidylethanolamine and lecithin,
0.1 to 60 wt % of a fatty acid or a salt thereof, and
10 to 99.8 wt % of a mixing solvent of water and alcohol, wherein the alcohol is at least one selected from a group consisting of ethanol, isopropanol, butanol, hexanol and oleyl alcohol, based on the total weight of the composition,
wherein the lecithin contains 3% or more of lysophosphatidylethanolamine, based on the total weight of the lecithin, and
wherein the water soluble composition containing lysophosphatidylethanolamine or lecithin maintains a clear formulation.
2. The composition according to claim 1 , wherein the lysophosphatidylethanolamine is hydrogenated lysophosphatidylethanolamine.
3. The composition according to claim 1 , wherein the composition comprises 5 to 20 wt % of one or both of lysophosphatidylethanolamine and lecithin, 5 to 20 wt % of a fatty acid or a salt thereof and 76 to 84 wt % of a mixing solvent of water and alcohol, based on the total weight of the composition.
4. The composition according to claim 1 , wherein the alcohol consists of ethanol or isopropanol, butanol, hexanol and oleyl alcohol.
5. The composition according to claim 4 , wherein a volume ratio of water:ethanol or isopropanol:butanol:hexanol:oleyl alcohol is 0.4˜4.0:0.2˜2.0:0.2˜2.0:0.2˜2.0:0.1˜1.0.
6. The composition according to claim 5 , wherein a volume ratio of water , ethanol or isopropanol, butanol, hexanol and oleyl alcohol is 1.6˜2.4:0.8˜1.2:0.8˜1.2:0.8˜1.2:0.4˜0.6.