Indole derivatives and their use as medicament

1. Indole compounds of the general Formula 1

in which

R denotes hydrogen; straight-chain or branched (C 1 -C 6 )-alkyl; (C 1 -C 6 )-alkyl which is mono- or polysubstituted by aryl, where the aryl radical [lacuna] unsubstituted or mono- to penta-[lacuna] by identical or different substituents from the group consisting of halogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, carboxyl, (C 1 -C 6 )-alkoxy-carbonyl, straight-chain or branched (C 1 -C 6 )-alkyl, which is substituted by one or more fluorine atoms, hydroxyl, straight-chain or branched (C 1 -C 6 )-alkoxy; benzyloxy or aryl-(C 1 -C 6 )-alkyl, where the aryl radical may be unsubstituted or mono- or pentasubstituted by identical or different substituents from the group consisting of (C 1 -C 6 )-alkyl, halogen and straight-chain or branched (C 1 -C 6 )-alkyl which is substituted by one or more fluorine atoms;

straight-chain or branched (C 1 -C 6 )-alkoxy-(C 1 -C 6 )-alkyl, substituted or unsubstituted aryl-(C 1 -C 6 )-alkyloxycarbonyl, straight-chain or branched (C 1 -C 6 )-alkyloxycarbonyl, straight-chain or branched (C 1 -C 6 )-alkylcarbonyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, or straight-chain or branched cyano-(C 1 -C 6 )-alkyl;

R 1 denotes a pyrido[2,3-b]-pyrazinyl group;

R 2 denotes hydrogen, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl which is mono- or polysubstituted by halogen, (C 1 -C 6 )-alkyl which is mono- or polysubstituted by phenyl, where the phenyl radical may be unsubstituted or mono- to pentasubstituted by identical or different substituents from the group consisting of halogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, carboxyl, (C 1 -C 6 )-alkoxycarbonyl, (C 1 -C 6 )-alkyl which is mono- or polysubstituted by halogen, hydroxyl, (C 1 -C 6 )-alkoxy, phenyl-(C 1 -C 6 )-alkoxy, nitro, amino, mono-(C 1 -C 6 )-alkylamino, di-(C 1 -C 6 )-alkylamino, mono-(C 3 - 6 )-cycloalkylamino, di-(C 3-6 )-cycloalkylamino, (C 1 -C 6 )-acylamino, phenyl-(C 1 -C 6 )-alkylamino, arylcarbonylamino, heteroarylcarbonylamino, (C 1 -C 6 )-alkylsulfonamido, arylsulfonamido, maleinimido, succinimido, phthalimido, benzyloxycarbonylamino (Z-amino), tert-butoxycarbonylamino (BOC-amino), 9-fluorenylmethoxycarbonylamino (Fmoc-amino), triphenylmethylamino (Tr-amino), 2-(4′-pyridyl)-ethoxycarbonylamino (Pyoc-amino), diphenylmethylsilylamino (DPMS-amino), —NH—CH 2 —COOH; —NH—CH(CH 3 )—COOH; (CH 3 ) 2 CH—CH 2 —CH 2 —CH(NH—)—COOH; H 3 C—CH 2 —CH(CH 3 )—CH(NH—)—COOH; HOH 2 C—CH(NH—)—COOH; phenyl-CH 2 —CH(NH—)—COOH; (4-imidazolyl)-CH 2 —CH(NH—)—COOH; HN═C(NH 2 )—NH—(CH 2 ) 3 —CH(NH—)—COOH; H 2 N—(CH 2 ) 4 —CH(NH—)—COOH; H 2 N—CO—CH 2 —CH(NH—)—COOH; or HOOC—(CH 2 ) 2 —CH(NH—)—COOH;

R 3 and R 4 may be attached to the indole carbon atoms C-2, C-4, C-5, C-6 or C-7 and independently of one another denote hydrogen, hydroxyl, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 1 -C 6 )-alkylcarbonyl, (C 1 -C 6 )-alkoxy, halogen, aryl-(C 1 -C 4 )-alkoxy, nitro, amino, mono-(C 1 -C 4 )-alkylamino, di-(C 1 -C 4 )-alkylamino, (C 1 -C 6 )-alkoxycarbonylamino, (C 1 -C 6 )-alkoxycarbonylamino-(C 1 -C 6 )-alkyl, cyano, straight-chain or branched cyano-(C 1 -C 6 )-alkyl, carboxyl, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkyl which is substituted by one or more fluorine atoms, carboxy-(C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkoxycarbonyl-(C 1 -C 6 )-alkyl;

Z 1 denotes oxygen or sulfur;

Z 2 denotes oxygen or sulfur, their tautomers, stereoisomers, including the diastereomers and enantiomers, and the physiologically acceptable salts thereof.

2. Indole compounds of the general formula (1) according to claim 1 , characterized in that R, R 2 , R 3 , R 4 , Z 1 and Z 2 have the meanings given above and R 1 depicts a pyrido[2,3-b]-pyranzinyl group.