Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates

1. A process for the preparation of a mixture of compounds of Formula 7a and Formula 7b

comprising the steps of reacting the mixture of compounds of Formula 6a and Formula 6b

with potassium carbonate and an alkylating agent to give a mixture of compounds of Formula 7a and Formula 7b

2. A process for isolating a compound of Formula 8

comprising the steps of dissolving the mixture of compounds of Formula 7a and Formula 7b

in hot acetonitrile and then cooling the solution to give a compound of Formula 8

3. A process for the preparation of a compound of Formula 9

comprising the steps of hydrolizing Formula 8

with an aqueous base to give a compound of Formula 9

4. A process of isolating a compound of Formula 11a

comprising the step of filtering the mixture of compounds of Formula 11a and Formula 11b

to isolate a compound of Formula 11a