6-and 7-amino isoquinoline compounds and methods for making and using the same
View Patent ↗6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
1. A compound of the formula:
or an optical isomer, diastereomer, enantiomer, or pharmaceutically acceptable salt thereof;
wherein R 1 is thienyl;
R 2 and R 3 are independently selected from H and C 1 -C 4 alkyl;
R 4 is H;
R 5 is NH 2 , H, or OH; and
R 7 is H.
2. A compound according to claim 1 , wherein the compound is of the formula
wherein R 1 is thienyl;
R 2 and R 3 are independently selected from H and C 1 -C 4 alkyl;
R 4 is H;
R 5 is NH 2 , H, or OH; and
R 7 is H.
3. A compound according to claim 1 , wherein R 1 is 2-thienyl.
4. A compound according to claim 1 , wherein R 1 is 3-thienyl.
5. A compound according to claim 1 , wherein R 2 and R 3 are both H.
6. A compound according to claim 1 , wherein R 2 and R 3 are both C 1 -C 4 alkyl.
7. A compound according to claim 1 , wherein R 5 is OH.
8. A compound of formula
or an optical isomer, diastereomer, enantiomer, or pharmaceutically acceptable salt thereof.
9. A pharmaceutical composition comprising a compound according to claim 1 and a carrier.
10. A pharmaceutical composition comprising a compound according to claim 8 and a carrier.
11. A method for treating a disease in a mammal comprising administering to a mammal a safe and effective amount of a compound according to claim 1 , wherein the disease comprises at least one of eye disease, bone disorder, obesity, heart disease, hepatic disease, renal disease, pancreatitis, cancer, myocardial infarct, gastric disturbance, hypertension, fertility control, nasal congestion, neurogenic bladder disorder, gastrointestinal disorder and dermatological disorder.
12. A method according to claim 11 , wherein the disease is an eye disease.
13. A method according to claim 12 , wherein the eye disease is glaucoma or a neurodegenerative eye disease.
14. A method according to claim 11 , wherein the compound is
or an optical isomer, diastereomer, enantiomer, or pharmaceutically acceptable salt thereof.