IP Library Granted Patent US 8,197,831
Granted Patent B2
US 8,197,831 · App. 12/011,825 · Granted Jun 12, 2012

Stable S-(+)-abscisic acid liquid and soluble granule formulations

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Quick Facts
Patent No.
US 8,197,831
App. No.
12/011,825
Granted
Jun 12, 2012
Kind
B2
Abstract

The present invention generally relates to stable S-(+)-abscisic acid liquid and soluble granule formulations and methods of making and using such formulations.

Claims (29)

1. A soluble 2-cis, 4-trans-(S)-abscisic acid granule formulation consisting of:

a) 2-cis, 4-trans-(S)-abscisic acid powder;

b) a lactose powder or a sucrose powder;

c) a sodium dioctyl sulfosuccinate wetting agent;

d) maltodextrin powder of about 10% dextrose equivalence;

e) Brij 98;

f) optionally citric acid;

g) and optionally water.

2. A soluble 2-cis, 4-trans-(S)-abscisic acid granule formulation consisting of:

a) about 21.1% by weight of 2-cis, 4-trans-(S)-abscisic acid powder;

b) about 71.0% by weight of lactose powder;

c) about 1.0% by weight of a sodium dioctyl sulfosuccinate wetting agent;

d) about 4.0% by weight of maltodextrin powder of about 10% dextrose equivalence;

e) about 1.0% by weight of Brij 98;

f) about 2.0% by weight of citric acid;

g) and optionally water.

3. A soluble 2-cis, 4-trans-(S)-abscisic acid granule formulation consisting of:

a) about 21.1% by weight of 2-cis, 4-trans-(S)-abscisic acid powder;

b) about 71.0% by weight of lactose powder;

c) about 1.0% by weight of a sodium dioctyl sulfosuccinate wetting agent;

d) about 4.0% by weight of maltodextrin powder of about 10% dextrose equivalence;

e) about 1.0% by weight of Brij 98;

f) and optionally water.

4. A process of making the soluble 2-cis, 4-trans-(S)-abscisic acid granule formulation of claim 1 comprising the steps of

a) blending the 2-cis, 4-trans-(S)-abscisic acid powder with the lactose or sucrose and the maltodextrin powder in the presence of the sodium dioctyl sulfosuccinate resulting in a formation of a dry blend;

b) wetting the blend with Brij 98;

c) mixing the blend of step (b) into a homogenous paste suitable for extrusion;

d) extruding the paste of step (c) into fine pellets of approximately uniform size; and

e) drying the pellets of step (d) to less than about 1% moisture.

Assignments (2)
MERGER Recorded May 11, 2017
From: VALENT BIOSCIENCES CORPORATION
To: VALENT BIOSCIENCES LLC
Reel/Frame 042446/0583 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2008
From: WANG, YUEH; WARRIOR, PREM; LONE, AHSAN; LOPEZ, JOHN; BALDI, BRUCE
To: VALENT BIOSCIENCES CORPORATION
Reel/Frame 021167/0723 →