Peptides that specifically bind HGF receptor (CMET) and uses thereof
View Patent ↗A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
1. A polypeptide or multimeric polypeptide comprising the amino acid sequence: Gly-X1-Cys-X2-Cys-X3-Gly-Pro-Pro-X4-Phe-X5-Cys-X6-Cys-X7-X8-X9-X10-Pro (SEQ ID NO:534), wherein
X1 is Ser;
X2 is His, Tyr or Asn;
X3 is Ser or Gly;
X4 is any amino acid other than Cys;
X5 is Glu;
X6 is Trp;
X7 is Tyr;
X8 is Gly, Asp, Ala, Glu or Ser;
X9 is Thr or Ser; and
X10 is Glu or Asp.
2. The polypeptide or multimeric polypeptide according to claim 1 , comprising the amino acid sequence of SEQ ID NO:405, 406, 408-411, 413-420, 422-436, or 438-447.
3. The polypeptide or multimeric polypeptide according to claim 1 , comprising the amino acid sequence of SEQ ID NO:410.
4. The polypeptide or multimeric polypeptide according to claim 1 , consisting of the amino acid sequence of SEQ ID NO:410.