Ionizing-radiation-responsive compositions, methods, and systems
View Patent ↗A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.
1. An ionizing-radiation-responsive composition, comprising:
a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band;
a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band; and
a matrix material disposed to at least partially sustain proximity of the luminescent material and the photosensitive biologically active material
wherein the matrix material includes an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material.
2. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material is disposed to at least partially bind together the luminescent material and the photosensitive biologically active material.
3. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material is disposed to transiently sustain proximity of at least a portion of the luminescent material and at least a portion of the photosensitive biologically active material.
4. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material is further disposed to at least partially improve at least one of the solubility, durability, suspension stability, bioactivity, biocompatibility, and non-toxicity of the ionizing-radiation-responsive composition.
5. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material includes a polymer.
6. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material includes a hydrogel.
7. The ionizing-radiation-responsive composition of claim 1 , wherein the matrix material includes silica.
8. The ionizing-radiation-responsive composition of claim 1 , wherein at least a portion of the luminescent material is embedded in the matrix material.
9. The ionizing-radiation-responsive composition of claim 1 , wherein at least a portion of the photosensitive biologically active material is embedded in the matrix material.
10. The ionizing-radiation-responsive composition of claim 1 , wherein at least a portion of the photosensitive biologically active material is attached to the surface of the matrix material.
11. An ionizing-radiation-responsive composition, comprising:
a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band; and
a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band; and
a coating material of a type selected to adjust at least one of the solubility, durability, suspension stability, bioactivity, biocompatibility, and non-toxicity of the ionizing-radiation-responsive composition;
wherein the coating material is disposed in a layer that at least partially encloses the photosensitive biologically active material; and
wherein the coating material includes an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material.
12. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material is disposed to at least partially sustain proximity of the luminescent material and the photosensitive biologically active material.
13. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material is disposed in a layer that at least partially encloses the luminescent material.
14. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material at least partially admits biological activity of the photosensitive biologically active material.
15. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material is selectively permeable.
16. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material includes a chelating agent.
17. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material includes a micellular agent.
18. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material includes a fullerene.
19. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material includes silica.
20. The ionizing-radiation-responsive composition of claim 11 , wherein the coating material includes a polymer.
21. The ionizing-radiation-responsive composition of claim 20 , wherein the polymer comprises polyethylene glycol.
22. An ionizing-radiation-responsive bound composition, comprising:
a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band; and
a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band; and
an optically-inhibiting material disposed to selectively block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material from sources other than the luminescent material.
23. The ionizing-radiation-responsive composition of claim 22 , wherein the optically-inhibiting material includes at least one metallic layer.
24. The ionizing-radiation-responsive composition of claim 23 , wherein the at least one metallic layer is configured as a mesh or porous structure.
25. The ionizing-radiation-responsive composition of claim 22 , wherein the optically-inhibiting material includes at least one chromophore having an absorption spectrum that at least partially coincides with the at least one wavelength band.
26. The ionizing-radiation-responsive composition of claim 22 , wherein the optically-inhibiting material includes at least one polymeric photonic band gap material having a band gap that at least partially coincides with the at least one wavelength band.