Taste-masked docusate compositions
View Patent ↗A taste-masked liquid composition of docusate includes a docusate salt, povidone, a polyether, and water. Additional ingredients in the composition may include thickeners, sweeteners, flavorants, polyols, preservatives, chelating agents and pH adjusters. Such compositions may be used as taste-masked oral compositions of docusate, and may provide therapeutic effects such as stool-softening.
1. A taste-masked liquid composition, comprising:
0.29 w/w % sodium docusate;
5 w/w % povidone;
5 w/w % polyethyleneglycol;
15 w/w % propylene glycol;
0.05 w/w % xanthan gum;
a sweetener comprising sorbitol, xylitol, and sucralose,
the sorbitol accounting for 5 w/w % to 25 w/w % of the composition, the xylitol accounting for about 5 w/w % to 40 w/w % of the composition, and the sucralose accounting for 0.1 w/w % to 1 w/w % of the composition;
a flavorant comprising fruit punch flavor, the fruit punch flavor accounting for 0.1 w/w % to 2 w/w % of the composition;
a pH adjuster comprising sodium citrate and citric acid,
the sodium citrate accounting for 0.05 w/w % to 2 w/w % of the composition, and the citric acid accounting for 0.05 w/w % to 2 w/w % of the composition;
a preservative comprising methyl paraben, edetate disodium and propyl paraben,
the methyl paraben accounting for 0.05 w/w % to 0.3 w/w % of the composition, and the propyl paraben accounting for 0.005 w/w % to 1 w/w % of the composition; and
a chelating agent comprising edentate disodium, the edentate disodium accounting for 0.01 w/w % to 1 w/w % of the composition,
wherein the sodium docusate is the sole pharmaceutically active agent.