Biofilm-inhibiting medical products
View Patent ↗A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
1. A medical product comprising:
a bismuth thiol, and
a bioremodelable extracellular matrix material comprising a fluidized submucosal tissue having viscosity of about 2 to about 300,000 cps at 25° C.; and
a biocompatible substrate layer adhered to the bioremodelable extracellular matrix material.
2. The medical product of claim 1 , wherein the bismuth thiol is selected from the group consisting of bismuth-1,2-ethanedithiol, bismuth-2-mercaptoethanol, bismuth-3,4-dimercaptotoluene, bismuth-pyrithione, bismuth-2,3-dimercaptopropanol, bismuth-1,3-propanedithiol, bismuth-dithiothreitol, bismuth-3-mercapto-2-butanol, and mixtures thereof.
3. The medical product of claim 1 , wherein the bismuth thiol is a bismuth dithiol.
4. The medical product of claim 1 , wherein the bismuth dithiol is bismuth-1,2-ethanedithiol.
5. The medical product of claim 1 , wherein the bioremodelable extracellular matrix material retains at least one growth factor from a source tissue.
6. The medical product of claim 5 , wherein the bioremodelable extracellular matrix material is in the form of a gel.
7. The of claim 6 , wherein the gel is formed from collagenous submucosal tissue material.
8. The medical product of claim 1 , further comprising at least one biofilm-inhibiting agent selected from the group consisting of lactoferrin, xylitol, quorum sensing inhibitor, biocidal agent, antibiotic, surfactant, and mixtures thereof.
9. The medical product of claim 1 ; where the medical is a hernia repair device.
10. The medical product of claim 9 , wherein the bismuth thiol is selected from the group consisting of bismuth-1,2-ethanedithiol, bismuth-2-mercaptoethanol, bismuth-3,4-dimercaptotoluene, bismuth-pyrithione, bismuth-2,3-dimercaptopropanol, bismuth-1,3-propanedithiol, bismuth-dithiothreitol, bismuth-3-mercapto-2-butanol, and mixtures thereof.
11. The medical product of claim 9 , wherein the bismuth thiol is a bismuth dithiol.
12. The medical product of claim 11 , wherein the bismuth dithiol is bismuth-1,2-ethanedithiol.
13. The medical product of claim 9 , further comprising at least one biofilm-inhibiting agent selected from the group consisting of lactoferrin, xylitol, quorum sensing inhibitor, biocidal agent, antibiotic, surfactant, and mixtures thereof.
14. The medical product of claim 1 ; wherein the medical product is a bioremodelable wound dressing.
15. The medical product of claim 1 , wherein the bismuth thiol is co-mixed with the bioremodelable extracellular matrix material.
16. The medical product of claim 1 , wherein the bioremodelable extracellular matrix material carries bismuth thiol.