Systems and methods for identifying a contra-ictal condition in a subject
The invention provides a method of monitoring a subject's neurological condition. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition, such as by activating a green light or other visible output. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition. The invention also provides neurological system monitors.
1. A method of identifying a contra-ictal status of a subject, the method comprising:
obtaining, by one or more physiological sensors, an electroencephalogram (EEG) signal dataset from the subject;
using a processor to complete steps of:
generating an N-dimensional feature vector for each of different time points of the EEG signal dataset;
identifying a grouping of contra-ictal feature vectors that is substantially free of pro-ictal feature vectors, wherein the contra-ictal feature vectors are associated with a low susceptibility of having a seizure and the pro-ictal feature vectors are associated with high susceptibility of having a seizure;
identifying a grouping of pro-ictal feature vectors that is substantially free of contra-ictal feature vectors;
using the grouping of contra-ictal feature vectors to provide an output associated with a contra-ictal status and using the grouping of pro-ictal feature vectors to provide an output associated with a pro-ictal status;
comparing the contra-ictal output to at least one threshold to determine a contra-ictal state;
comparing the pro-ictal output to at least one threshold to determine a pro-ictal state;
selecting an indicator from among at least three indicators based on the contra-ictal state and the pro-ictal state, each of the at least three indicators corresponding to a different susceptibility of having a seizure, wherein the selected indicator indicates whether the subject has the contra-ictal status; and
displaying, by a seizure advisory system, the selected indicator.
2. The method of claim 1 further comprising storing the identified grouping of contra-ictal feature vectors or a mathematical representation of the identified grouping of contra-ictal feature vectors in memory.
3. The method of claim 1 further comprising customizing a contra-ictal algorithm for the subject based on the N-dimensional feature vector and the processor using the customized contra-ictal algorithm.
4. The method of claim 1 , wherein the displaying of the indicator includes a report that a seizure is unlikely to occur for a time period.
5. The method of claim 4 , wherein the time period is at least one of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, greater than 5 minutes, greater than 15 minutes, greater than 30 minutes, greater than 60 minutes, and greater than 90 minutes.
6. The method of claim 1 , wherein the indicator is the identification of the contra-ictal status of the subject and corresponds to a time period that the subject is estimated to remain in the contra-ictal status.
7. The method of claim 6 , wherein the time period is at least one of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, greater than 5 minutes, greater than 15 minutes, greater than 30 minutes, greater than 60 minutes, and greater than 90 minutes.
8. The method of claim 1 , wherein selecting the indicator comprises:
selecting a first indicator of the at least three indicators in response to the contra-ictal output being above at least one threshold and the pro-ictal output being below at least one threshold, the first indicator corresponding to a low susceptibility of having a seizure;
selecting a second indicator of the at least three indicators in response to the contra-ictal output being below at least one threshold and the pro-ictal output being above at least one threshold, the second indicator corresponding to a high susceptibility of having a seizure;
selecting a third indicator of the at least three indicators in response to the contra-ictal output being below at least one threshold and the pro-ictal output being below at least one threshold, the third indicator corresponding to neither the contra-ictal state nor the pro-ictal state; and
selecting the third indicator of the at least three indicators in response to the contra-ictal output being above at least one threshold and the pro-ictal output being above at least one threshold.
9. The method of claim 8 , wherein the first indicator is a green light, the second indicator is a red light, and the third indicator is a yellow light.
10. A method of identifying a contra-ictal status of a subject, the method comprising:
obtaining, by one or more physiological sensors, an electroencephalogram (EEG) signal dataset from the subject, the EEG signal dataset including contra-ictal data corresponding to a contra-ictal status of the subject in which the subject has a low susceptibility of having a seizure for a time period, the EEG signal dataset further including pro-ictal data corresponding to a pro-ictal status of the subject in which the subject has a high susceptibility of having a seizure;
using a processor to complete steps of:
distinguishing the contra-ictal data from the pro-ictal data within the EEG signal dataset;
providing an output associated with the contra-ictal status and providing an output associated with the pro-ictal status based on the distinguished data;
comparing the contra-ictal output to at least one threshold to determine a contra-ictal state;
comparing the pro-ictal output to at least one threshold to determine a pro-ictal state;
selecting an indicator from among at least three indicators based on the contra-ictal state and the pro-ictal state, each of the at least three indicators corresponding to a different susceptibility of having a seizure, wherein the selected indicator indicates whether the subject has the contra-ictal status;
displaying, by a seizure advisory system, the selected indicator; and
reporting, by the processor, the contra-ictal status of the subject.
11. The method of claim 10 , wherein the time period is at least one of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, greater than 5 minutes, greater than 15 minutes, greater than 30 minutes, greater than 60 minutes, and greater than 90 minutes.
12. The method of claim 10 , wherein the reporting is to the subject or a care provider of the subject.
13. The method of claim 10 , wherein the reporting includes reporting the time period.
14. The method of claim 13 , wherein the time period is at least one of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, greater than 5 minutes, greater than 15 minutes, greater than 30 minutes, greater than 60 minutes, and greater than 90 minutes.
15. The method of claim 10 , further comprising:
providing a therapeutic response to the subject.
16. A method of identifying a contra-ictal status of a subject, the method comprising:
obtaining, by one or more physiological sensors, an electroencephalogram (EEG) signal dataset from the subject, the EEG signal dataset corresponding to a normal non-seizure status of the subject;
using a processor to complete steps of:
distinguishing contra-ictal data from pro-ictal data within the EEG signal dataset, wherein the contra-ictal data is associated with a low susceptibility of having a seizure and the pro-ictal data is associated with a high susceptibility of having a seizure;
in response to distinguishing the contra-ictal data from the pro-ictal data, providing an output associated with a contra-ictal status for a time period and providing an output associated with a pro-ictal status for the time period, the time period being a future period of time;
comparing the contra-ictal output to at least one threshold to determine a contra-ictal state for the time period;
comparing the pro-ictal output to at least one threshold to determine a pro-ictal state for the time period;
selecting an indicator from among at least three indicators based on the contra-ictal state and the pro-ictal state, each of the at least three indicators corresponding to a different susceptibility of having a seizure for the time period, wherein the selected indicator indicates whether the subject has the contra-ictal status; and
displaying, by a seizure advisory system, the selected indicator.
17. The method of claim 16 , wherein the time period is at least one of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, greater than 5 minutes, greater than 15 minutes, greater than 30 minutes, greater than 60 minutes, and greater than 90 minutes.
18. The method of claim 16 , further comprising:
providing a therapeutic response to the subject.