Correlating chemical and spatial data within pathology samples
View Patent ↗A tissue sample to be analyzed is tested. Multiple different samples of multiple areas of said tissue sample, each of said multiple areas is a smaller area than an entire tissue sample to be analyzed. After analysis, the tissue sample is processed in a way that facilitates viewing tumor information on the sample, for example, by fixing or staining. An area is identified on the stained sample, and at least one of the samples that corresponds to an identified area is tested. This small area is tested using a technique that homogenizes the sample before testing.
1. A method comprising:
obtaining a previously excised tissue sample to be analyzed;
first isolating multiple different portions from multiple different locations of said tissue sample, each of said multiple locations being smaller than the entire tissue sample to be analyzed;
after said first isolating, processing said excised tissue sample in a way that facilitates visualizing tumor information on said sample;
identifying an area of interest within said processed tissue sample using microscopic evaluation after said processing of said tissue sample; and
selecting and testing at least one of said portions, wherein selecting is based on the tumor information in the area of interest.
2. A method as in claim 1 , wherein said first isolating uses a tool that takes the multiple different portions spaced from one another.
3. A method as in claim 1 , wherein said processing comprises staining the excised tissue sample.
4. A method as in claim 1 , wherein said testing comprises using a test that homogenizes the at least one of said portions as part of the testing.
5. A method as in claim 4 , wherein said testing uses PCR, Western blotting, a DNA array or an RNA array.
6. A method as in claim 2 , wherein said multiple different portions have asymmetrical arrangement relative to each other.
7. A method as in claim 1 , further comprising maintaining an orientation of said multiple different portions, with a specified surface of said multiple different locations all facing in a same direction.
8. A method as in claim 7 , wherein said taking multiple samples comprises contacting a surface of the tissue sample, and wherein a contacted surface orientation is maintained in a specified way.