Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer

1. An ophthalmic composition comprising:

0.01 wt. % to 2 wt. % of an amphoteric surfactant of general formula I

wherein R l is a C 8 -C 16 alkyl; R 2 and R 3 are methyl; R 4 is a C 2 -C 4 alkylene; and Y is SO 3 − ;

0.5 ppm to 2 ppm of α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride;

0.5 ppm to 2.0 ppm poly(hexamethylene biguanide);

0.01 wt. % to 0.05 wt. % ethylenediaminetetraacetic acid or a corresponding salt thereof;

a borate buffer; and

0.002 wt. % to 0.03 wt. % of hyaluronic acid, wherein the ophthalmic composition satisfies the biocidal requirements of Stand-Alone Procedure for Disinfecting Products.

2. The composition of claim 1 wherein the amphoteric surfactant is present from 0.01 wt. % to 1 wt. %.

3. The composition of claim 1 further comprising dexpanthenol, sorbitol, glycolic acid, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

4. The composition of claim 3 further comprising citrate, citric acid or a mixture thereof.

5. The composition of claim 1 further comprising propylene glycol, hydroxypropyl guar or myristamidopropyl dimethylamine.

6. The composition of claim 1 further comprising hydroxypropylmethyl cellulose.

7. An ophthalmic composition comprising:

0.5 ppm to 1.8 ppm of poly(hexamethylene biguanide);

0.5 ppm to 2 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride;

0.002 wt. % to 0.03 wt. % hyaluronic acid;

0.01 wt. % to 0.05 wt. % ethylenediaminetetraacetic acid or a corresponding salt thereof;

a borate buffer; and

0.01 wt. % to 0.8 wt. % of an amphoteric surfactant of general formula I

wherein R l is a C 8 -C 16 alkyl; R 2 and R 3 are methyl; R 4 is a C 2 -C 4 alkylene; and Y is SO 3 − ,

wherein the ophthalmic composition satisfies the biocidal requirements of Stand-Alone Procedure for Disinfecting Products.

8. The composition of claim 7 further comprising citrate, citric acid or a mixture thereof.

9. The composition of claim 7 further comprising propylene glycol, hydroxypropyl guar or myristamidopropyl dimethylamine.

10. The composition of claim 7 further comprising dexpanthenol, sorbitol, glycolic acid, 2-amino-2-methyl-1,3-propanediol, hydroxypropylmethyl cellulose or any one mixture thereof.

11. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in the ophthalmic composition of claim 1 for at least two hours.

12. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in the ophthalmic composition of claim 7 for at least two hours.

13. The method of claim 11 further comprising inserting the cleaned and disinfected contact lens into the eye without rinsing the lens after soaking.

14. The method of claim 12 further comprising inserting the cleaned and disinfected contact lens into the eye without rinsing the lens after soaking.

15. The method of claim 11 further comprising rinsing the cleaned and disinfected contact lens with the composition of claim 1 prior to inserting the lens into the eye.

16. The composition of claim 1 , comprising 1 ppm of α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride.