METHOD OF TREATMENT OF NEUROLOGICAL INJURY OR CANCER BY ADMINISTRATION OF DICHLOROACETATE
A method for treating neurological injury or cancer in a patient includes administration of a therapeutically-effective amount of dichloroacetic acid (DCA), a therapeutically-effective amount of electromagnetic radiation, or both to the patient.
1 . A method of providing treatment to a patient with a neurological injury, the method comprising administering a therapeutically-effective amount of dichloroacetic acid (DCA) to the patient.
2 . The method of claim 1 , wherein the therapeutically-effective amount of DCA is administered orally.
3 . The method of claim 1 , wherein the therapeutically-effective amount of DCA is administered intravenously.
4 . The method of claim 1 , wherein the therapeutically-effective amount of DCA is in a range between about 1.0 mg/kg/day and about 25 mg/kg/day.
5 . The method of claim 1 , wherein the neurological injury comprises traumatic brain injury.
6 . The method of claim 1 , wherein the neurological injury comprises ischemic stroke.
7 . The method of claim 1 , the method further comprising applying a therapeutically-effective amount of electromagnetic radiation to the brain.
8 . The method of claim 7 , wherein the therapeutically-effective amount of electromagnetic radiation is applied within 5 days of the onset of neurological injury.
9 . The method of claim 7 , wherein the therapeutically-effective amount of electromagnetic radiation has a wavelength within a range between about 630 nanometers and about 1064 nanometers.
10 . The method of claim 7 , wherein the therapeutically-effective amount of electromagnetic radiation comprises a power density of at least 0.01 mW/cm 2 .
11 . The method of claim 7 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed concurrently with administering the therapeutically-effective amount of DCA.
12 . The method of claim 7 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed non-concurrently with administering the therapeutically-effective amount of DCA.
13 . The method of claim 12 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed before administering the therapeutically-effective amount of DCA.
14 . A method of providing treatment to a cancer patient, the method comprising applying a therapeutically-effective amount of electromagnetic radiation to the patient.
15 . The method of claim 14 , wherein the electromagnetic radiation has a wavelength within a range between about 630 nanometers and about 1064 nanometers.
16 . The method of claim 14 , wherein the therapeutically-effective amount of electromagnetic radiation comprises a power density of at least 0.01 mW/cm 2 .
17 . A method of providing treatment to a cancer patient, the method comprising administering a therapeutically-effective amount of dichloroacetic acid (DCA) and applying a therapeutically-effective amount of electromagnetic radiation to the patient.
18 . The method of claim 17 , wherein the therapeutically-effective amount of DCA is administered orally.
19 . The method of claim 17 , wherein the therapeutically-effective amount of DCA is administered intravenously.
20 . The method of claim 17 , wherein the therapeutically-effective amount of DCA is in a range between about 1.0 mg/kg/day and about 25 mg/kg/day.
21 . The method of claim 17 , wherein the electromagnetic radiation has a wavelength within a range between about 630 nanometers and about 1064 nanometers.
22 . The method of claim 17 , wherein the therapeutically-effective amount of electromagnetic radiation comprises a power density of at least 0.01 mW/cm 2 .
23 . The method of claim 17 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed concurrently with administering the therapeutically-effective amount of DCA.
24 . The method of claim 17 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed non-concurrently with administering the therapeutically-effective amount of DCA.
25 . The method of claim 24 , wherein applying the therapeutically-effective amount of electromagnetic radiation is performed before administering the therapeutically-effective amount of DCA.