IP Library › Granted Patent US 7,824,702
Granted Patent B2
US 7,824,702 · App. 12/026,327 · Granted Nov 2, 2010

Composition for making a bone paste

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Quick Facts
Patent No.
US 7,824,702
App. No.
12/026,327
Granted
Nov 2, 2010
Kind
B2
Abstract

Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.

Claims (10)

1. A reconstituted paste composition comprising freeze-dried demineralized bone matrix (DBM) particles and a carrier, wherein said carrier is gelatin; wherein said freeze-dried DBM particles are about 250 microns to about 500 microns in size; wherein said gelatin is in the form of granules having a size of about 125 microns to about 710 microns; and a reconstitution fluid, wherein said reconstitution fluid is selected from the group consisting of water, water-based salines, blood, protein solutions, gelatin solutions, growth factor solutions, antibiotic solutions, analgesic solutions, platelet rich plasma, crude platelet extract, and combinations thereof.

2. The composition of claim 1 , wherein said gelatin is in the form of granules having a size of about 125 microns to about 500 microns.

3. The composition of claim 1 , wherein said gelatin is in the form of granules having a size of about 500 microns to about 710 microns.

4. The composition of claim 1 , further comprising an osteoconductive material.

5. The composition of claim 4 , wherein said osteoconductive material is selected from the group consisting of hydroxyapatite (HA), tricalcium phosphate (TCP), cortico-cancellous chips (CCC), bioactive glass, bioactive ceramics, and mixtures thereof.

6. The composition of claim 5 , wherein said osteoconductive material is cortico-cancellous chips (CCC).

7. The reconstituted paste composition of claim 1 , wherein said reconstitution fluid is water.

8. The reconstituted paste composition of claim 1 , wherein the composition is in a container.

9. The reconstituted paste composition of claim 1 , wherein the container is a syringe.

10. A method of treating a bone defect or injury comprising administering the paste composition of claim 1 to a site of need.

Assignments (18)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS AND TRADEMARKS Recorded Sep 25, 2025
From: ARES CAPITAL CORPORATION
To: RTI SURGICAL INC. D/B/A EVERGEN
Reel/Frame 072938/0203 →
RELEASE OF SECURITY INTEREST Recorded Jul 21, 2020
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.
Reel/Frame 053260/0398 →
SECURITY INTEREST Recorded Jul 21, 2020
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL (UNITED STATES), INC.
To: ARES CAPITAL CORPORATION, AS SECURITY AGENT
Reel/Frame 053273/0665 →
INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT Recorded Jul 20, 2020
From: SURGALIGN SPINE TECHNOLOGIES, INC. (FORMERLY KNOWN AS RTI SURGICAL, INC.)
To: RTI OEM, LLC
Reel/Frame 053259/0019 →
CHANGE OF NAME Recorded Jul 20, 2020
From: RTI OEM, LLC
To: RTI SURGICAL, INC.
Reel/Frame 053259/0146 →
CHANGE OF NAME Recorded Jul 20, 2020
From: RTI SURGICAL, INC.
To: SURGALIGN SPINE TECHNOLOGIES, INC.
Reel/Frame 053248/0432 →
RELEASE OF SECURITY INTEREST Recorded Jul 20, 2020
From: ARES CAPITAL CORPORATION, AS AGENT
To: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.; PARADIGM SPINE, LLC; FOURTH DIMENSION SPINE, LLC
Reel/Frame 053257/0652 →
SECURITY INTEREST Recorded Mar 8, 2019
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.; PARADIGM SPINE, LLC; FOURTH DIMENSION SPINE, LLC
To: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 048543/0505 →
RELEASE OF SECURITY INTEREST Recorded Jun 7, 2018
From: TD BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.
Reel/Frame 046327/0184 →
RELEASE OF SECURITY INTEREST Recorded Jun 7, 2018
From: TD BANK, N.A., AS ADMINISTRATIVE AGENT
To: RTI SURGICAL, INC.
Reel/Frame 046327/0864 →
SECURITY INTEREST Recorded Jun 6, 2018
From: RTI SURGICAL, INC.; PIONEER SURGICAL TECHNOLOGY, INC.; TUTOGEN MEDICAL, INC.
To: JPMORGAN CHASE BANK, N.A., AS THE ADMINISTRATIVE AGENT
Reel/Frame 046303/0926 →
SECURITY INTEREST Recorded Aug 20, 2017
From: RTI SURGICAL, INC.
To: TD BANK, N.A.
Reel/Frame 043608/0874 →
MERGER Recorded Dec 10, 2013
From: REGENERATION TECHNOLOGIES, INC. (A FLORIDA CORPORATION)
To: REGENERATION TECHNOLOGIES, INC. (A DELAWARE CORPORATION)
Reel/Frame 031753/0334 →
CHANGE OF NAME Recorded Aug 14, 2013
From: RTI BIOLOGICS, INC.
To: RTI SURGICAL, INC.
Reel/Frame 031012/0159 →
SECURITY AGREEMENT Recorded Jul 26, 2013
From: RTI SURGICAL, INC.
To: TD BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 030888/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2013
From: REGENERATION TECHNOLOGIES, INC.
To: REGENERATION TECHNOLOGIES, INC.
Reel/Frame 030770/0978 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 10, 2013
From: WIRONEN, JOHN F.; KAO, PENELOPE; BERNHARDT, ANDY
To: REGENERATION TECHNOLOGIES, INC.
Reel/Frame 030770/0925 →
CHANGE OF NAME Recorded Mar 26, 2008
From: REGENERATION TECHNOLOGIES, INC.
To: RTI BIOLOGICS, INC.
Reel/Frame 020690/0942 →