IP Library › Granted Patent US 7,544,212
Granted Patent B2
US 7,544,212 · App. 12/029,095 · Granted Jun 9, 2009

Bone implant composite

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,544,212
App. No.
12/029,095
Granted
Jun 9, 2009
Kind
B2
Abstract

A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 μm and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 μm, a density range of 0.02-0.8 g/cm 3 , a tensile strength range of 0.4-100 kg/cm 2 , and a compression modulus range of 0.2-10 kg/cm 2 . Also disclosed are methods of preparing the above-described composite.

Claims (17)

1. A bone implant composite comprising a swollen, freeze-dried and crosslinked collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 μm and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 μm, a density range of 0.02-0.8 g/cm 3 , a tensile strength range of 0.4-100 kg/cm 2 , and a compression modulus range of 0.2 to 10 kg/cm 2 .

2. The bone implant composite of claim 1 , wherein the particle size of the calcium-based mineral is 30-1000 μm.

3. The bone implant composite of claim 1 , wherein the bone implant composite contains 5-55% by weight the collagen matrix and 45-95% by weight the calcium-based mineral.

4. The bone implant composite of claim 3 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.

5. The bone implant composite of claim 1 , wherein the bone implant composite has a pore size of 150-500 μm.

6. The bone implant composite of claim 1 , wherein the bone implant composite has a density range of 0.03-0.7 g/cm 3 .

7. The bone implant composite of claim 1 , wherein the bone implant composite has a tensile strength range of 0.5-10 kg/cm 2 .

8. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral.

9. The bone implant composite of claim 1 , wherein the calcium-based mineral is carbonate apatite.

10. The bone implant composite of claim 9 , wherein the carbonate content of the carbonate apatite ranges from 2 to 12%.

11. The bone implant composite of claim 1 , wherein the composite has a compression modulus range of 0.6 to 5.0 kg/cm 2 .

12. The bone implant composite of claim 1 , wherein the composite has a compression modulus of 0.5-0.8 kg/cm 2 .

13. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral and has a particle size of 30-1000 μm; and the bone implant composite contains 5-55% by weight the collagen matrix and 45-95% by weight the anorganic bone mineral, and has a pore size of 150-500 μm, a density range of 0.03-0.7 g/cm 3 , a tensile strength range of 0.5-10 kg/cm 2 , and a compression modulus range of 0.6 to 5.0 kg/cm 2 .

14. The bone implant composite of claim 13 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.

15. The bone implant composite of claim 1 , wherein the calcium-based mineral is anorganic bone mineral and has a particle size of 30-150 μm; and the bone implant composite contains 45-55% by weight the collagen matrix and 45-55% by weight the anorganic bone mineral, and has a pore size of 150-500 μm, a density of 0.035-0.055 g/cm 3 , a tensile strength of 0.5-0.8 kg/cm 2 , and a compression modulus of 0.5-0.8 kg/cm 2 .

16. The bone implant composite of claim 1 , wherein the calcium-based mineral is carbonate apatite and has a particle size of 30-1000 μm; and the bone implant composite contains 5-55% by weight the collagen matrix and 45-95% by weight the carbonate apatite, and has a pore size of 50-200 μm, a density range of 0.03-0.7 g/cm 3 , a tensile strength range of 0.5-10 kg/cm 2 , and a compression modulus range of 0.6 to 5.0 kg/cm 2 .

17. The bone implant composite of claim 16 , wherein the bone implant composite contains 20-40% by weight the collagen matrix and 60-80% by weight the calcium-based mineral.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Jan 26, 2026
From: GOLUB CAPITAL MARKETS LLC, AS ADMINISTRATIVE AGENT
To: COLLAGEN MATRIX, INC.
Reel/Frame 073583/0580 →
SECURITY INTEREST Recorded Jan 26, 2026
From: COLLAGEN MATRIX, INC.
To: GOLUB CAPITAL MARKETS LLC, AS COLLATERAL AGENT
Reel/Frame 073583/0614 →
RELEASE OF SECURITY INTEREST IN PATENTS RECORDED AT R/F 049933/0378 Recorded Aug 1, 2024
From: THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY
To: COLLAGEN MATRIX, INC.
Reel/Frame 068256/0450 →
FIRST LIEN PATENT SECURITY AGREEMENT Recorded Aug 1, 2019
From: COLLAGEN MATRIX, INC.
To: GOLUB CAPITAL, LLC
Reel/Frame 051594/0368 →
SECURITY INTEREST Recorded Aug 1, 2019
From: COLLAGEN MATRIX, INC.
To: THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY
Reel/Frame 049933/0378 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Aug 1, 2019
From: CAPITAL ONE, NATIONAL ASSOCIATION
To: COLLAGEN MATRIX, INC.
Reel/Frame 049934/0317 →
ASSIGNMENT OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Nov 14, 2015
From: GENERAL ELECTRIC CAPITAL CORPORATION, AS RETIRING AGENT
To: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS SUCCESSOR AGENT
Reel/Frame 037111/0808 →
SECURITY INTEREST Recorded Oct 23, 2014
From: COLLAGEN MATRIX, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 034021/0474 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2008
From: LI, SHU-TUNG; YUEN, DEBBIE; CHEN, HUI-CHEN
To: COLLAGEN MATRIX, INC.
Reel/Frame 020494/0382 →