COLLAGEN PRODUCTS AND METHODS FOR PRODUCING COLLAGEN PRODUCTS
Medical implants and methods for forming a medical implant blends a dispersion of human collagen fibers and/or threads and optionally a volume between about 2 to about 15% of an alcohol and forms medical implants by removing a liquid component of the collagen dispersion. Medical implants formed include collagen films, coatings, threads, patches, tubes, plugs, scaffolds, injectable collagen, and collagen for in vitro applications.
1 . Human-derived collagen product fibers and/or threads having a preserved amount of native constituents.
2 . The human-derived collagen product of claim 1 , wherein the native constituents comprise one or more of non-collagenous proteins, growth factors, cells, and extracellular matrix.
3 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads comprise a length of about 10 cm to about 50 microns.
4 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads are ground collagen fibers.
5 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads are milled collagen fibers and/or threads.
6 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads comprises fibrillar collagen.
7 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads is derived from fascia.
8 . The human-derived collagen product of claim 7 , wherein the fascia is tensor fascia lata.
9 . The human-derived collagen product of claim 1 , wherein the collagen fibers and/or threads is a hemostat.
10 . The human-derived collagen product of claim 1 , wherein the collagen product fibers and/or threads is a collagen product strand.
11 . The human-derived collagen product of claim 10 , wherein the collagen strand comprises a diameter of about 50 microns to about 3 millimeters.
12 . The human-derived collagen product of claim 11 , wherein the collagen strand is an extruded monofilament having a diameter of about 50 microns to about 200 microns.
13 . The human-derived collagen product of claim 11 , wherein the collagen strand is formed by electrostatic spinning and comprises a diameter of about 50 nanometers to about 400 nanometers.
14 . The human-derived collagen product of claim 10 , wherein the collagen strand is a collagen rope formed from a plurality of the collagen strands, wherein the collagen rope comprises a diameter of between about 200 microns to about 3 millimeters.
15 . An intermediate collagen product comprising human or human-like collagen fibers and/or threads dispersed in a volume of water, wherein the human collagen comprises a preserved amount of its native constituents.
16 . An intermediate collagen product comprising a foam containing at least human collagen fibers and/or threads and a leveling agent, wherein the human collagen in the foam comprises a preserved amount of native constituents.
17 . The intermediate collagen product of claim 16 , wherein the leveling agent is an alcohol, wherein the volume of the alcohol comprises between about 2% to about 15% and has a purity of about 70% to about 99%.
18 . The intermediate collagen product of claim 16 , wherein the collagen fibers and/or threads is derived from human fascia.
19 . The intermediate collagen product of claim 18 , wherein the fascia is tensor fascia lata.
20 . An intermediate collagen product comprising human-derived collagen fibers and/or threads dispersed in a volume of water and an alcohol, wherein the volume of alcohol comprises between about 2% to about 15% and has a purity of about 70% to about 99%, and wherein the human-derived collagen comprises a preserved amount of native constituents.
21 . The intermediate collagen product of claim 20 , wherein the collagen fibers and/or threads is derived from human fascia.
22 . The intermediate collagen product of claim 21 , wherein the fascia is tensor fascia lata.
23 . A collagen product implant produced from human collagen having a preserved amount of native constituents, said collagen implant comprising elasticity and plasticity performance characteristics that causes the implant to generally return to its original shape when manipulated.
24 . The collagen product implant of claim 23 , wherein the collagen implant is a collagen scaffold, said collagen scaffold comprising flexibility and resistivity to cracking performance characteristics that causes the implant to generally conform to an implant area when implanted.
25 . The collagen product implant of claim 23 , wherein the collagen is derived from human fascia.
26 . The collagen product implant of claim 25 , wherein the fascia is tensor fascia lata.
27 . A method for preparing a human or human-like derived collagen product, comprising:
treating harvested human or human-like tissue with an enzyme to form a collagen product;
deactivating the enzyme with a non-alkaline enzyme deactivation solution; and
collecting the collagen product resulting from the enzyme treatment, the collected collagen product having a preserved amount of its natural collagen constituents.
28 . The method of claim 27 , wherein the harvested tissue-containing collagen is a tendon.
29 . The method of claim 27 , wherein the harvested tissue-containing collagen is pericardial tissue.
30 . The method of claim 27 , wherein the harvested tissue-containing collagen is intestinal tissue.
31 . The method of claim 27 , wherein the harvested tissue-containing collagen is fascia.
32 . The method of claim 27 , wherein the harvested tissue-containing collagen contains type I collagen.
33 . The method of claim 27 , wherein the harvested tissue-containing collagen contains type III collagen.
34 . The method of claim 27 , wherein the harvested tissue-containing collagen contains type V collagen.
35 . The method of claim 27 , wherein the harvested tissue-containing collagen contains two or more of type I collagen, type III collagen, and type V collagen.
36 . The method of claim 27 , wherein the enzyme is a hydrolytic enzyme.
37 . The method of claim 36 , wherein the enzyme is a proteolytic enzyme.
38 . The method of claim 27 , wherein the collagen product is processed to include a bioactive agent.
39 . The method of claim 27 , wherein collecting the collagen product comprises:
washing the collagen product; and
drying the collagen product.
40 . A collagen product medical implant comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.
41 . The medical implant of claim 40 , wherein the collagen product is fibrillar collagen.
42 . The medical implant of claim 40 , wherein the collagen product is particulate collagen.
43 . The medical implant of claim 40 , wherein said implant comprises a wound repair matrix.
44 . The medical implant of claim 40 , wherein said implant comprises an absorbent hemostat.
45 . The medical implant of claim 40 , wherein said implant comprises a medical repair patch.
46 . The medical implant of claim 45 , wherein the medical repair patch is a woven patch.
47 . The medical implant of claim 45 , wherein the medical repair match is a non-woven patch.
48 . The medical implant of claim 45 , wherein the medical repair patch is a braided patch.
49 . The medical implant of claim 45 , wherein the medical repair patch is a film patch.
50 . The medical implant of claim 45 , wherein the medical repair patch is a knitted patch.
51 . The medical implant of claim 45 , wherein the medical repair patch is at least two of a woven, a non-woven, a braided, a film, and a knitted patch.
52 . The medical implant of claim 40 , wherein said implant comprises a vascular graft.
53 . The medical implant of claim 40 , wherein said implant comprises a neural graft.
54 . The medical implant of claim 40 , wherein said implant comprises a cartilage repair structure.
55 . The medical implant of claim 40 , wherein said implant comprises a sphincter repair matrix.
56 . The medical implant of claim 40 , wherein said implant comprises a film.
57 . The medical implant of claim 40 , wherein said implant comprises a prosthetic having a coating of the enzymatically-treated human derived collagen.
58 . The medical implant of claim 40 , wherein said implant comprises an implantable instrument having a coating of the enzymatically-treated human derived collagen.
59 . The medical implant of claim 40 , wherein said implant comprises a structural support sling.
60 . The medical implant of claim 40 , wherein said implant comprises a bioactive agent.
61 . The medical implant of claim 40 , wherein said implant comprises a plug (is cartilage repair structure from claim 54 sufficient?).
62 . The medical implant of claim 40 , wherein said implant is for in vitro applications.
63 . The medical implant of claim 40 , wherein said implant is injectable.
64 . The medical implant of claim 40 , wherein said implant is reinforced.
65 . A method for forming a medical implant, comprising:
dispersing in solution an isolated, enzymatically-treated human derived collagen product having a preserved amount of its natural constituents;
forming the dispersed collagen product into a medical implant; and
removing the liquid component of the collagen product dispersion.
66 . The method of claim 65 , wherein dispersing human derived collagen product comprises at least suspending the human derived collagen product in a solution.
67 . The method of claim 65 , wherein said liquid component is removed by evaporating.
68 . The method of claim 67 , wherein evaporating the liquid component of the collagen product dispersion comprises lyophilizing the collagen product dispersion.
69 . The method of claim 68 , wherein evaporating the liquid component of the collagen product dispersion comprises freezing and lyophilizing the collagen product dispersion.
70 . The method of claim 65 , further comprising cross-linking the collagen dispersion.
71 . A method for forming a medical implant, comprising:
causing an enzymatically-treated human derived collagen product having a preserved amount of its natural constituents in a solution to react to form a collagen thread; and
forming a collagen fabric from the collagen thread.
72 . The method of claim 71 , wherein said collagen fabric is a woven collagen fabric.
73 . The method of claim 71 , wherein said collagen fabric is a non-woven collagen fabric.
74 . A method for forming a medical implant, comprising:
depositing a dispersion of an enzymatically-treated human derived collagen product having an amount of its natural constituents preserved in a mold having a predetermined shape; and
evaporating the liquid in the collagen product dispersion.
75 . A method for processing a medical implant, comprising:
processing an enzymatically-treated human derived collagen product having an amount of its natural constituents preserved into a gelatin; and
coating the medical implant with the gelatin.
76 . A medical implant comprising:
reconstituted human derived collagen,
wherein the human derived collagen product comprises a preserved amount of its native human collagen constituents.
77 . A method for providing a medical implant comprising:
reconstituting an isolated human derived collagen product, wherein the human derived collagen product comprises a preserved amount of native human collagen constituents; and
forming a medical implant using the reconstituted human derived collagen product.
78 . A human-derived collagen product having a preserved amount of native constituents.
79 . The collagen product implant of claim 23 , wherein the collagen implant is a compressed collagen scaffold, said compressed collagen scaffold that is drapeable and/or resistant to suture pullout.
80 . The collagen product implant of claim 23 , wherein the collagen implant is a compressed collagen scaffold, said compressed collagen scaffold configured to form a seal with an implant area.