Ophthalmic device comprising a holographic sensor
View Patent ↗An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
1. An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a reflection hologram,
wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium,
wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid, and
wherein the reflection hologram is disposed in only a part of the ophthalmic device.
2. The device according to claim 1 , wherein the holographic element does not contain silver.
3. The device according to claim 1 , wherein the interaction is a reversible chemical reaction.
4. The device according to claim 1 , wherein the analyte is glucose.
5. The device according to claim 1 , wherein the medium is a polymer of monomers including acrylamide.
6. The device according to claim 1 , wherein the medium is a polymer of monomers including 3-acrylamidophenylboronic acid.
7. The device according to claim 5 , wherein the medium comprises a group which is capable of repelling lactate, the group comprising a substantial negative charge.
8. The device according to claim 5 , wherein the medium comprises an amine group.
9. The device according to claim 1 , wherein the ophthalmic device is a contact lens.
10. A method of detection of an analyte in an ocular fluid, which comprises:
inserting in a user's eye a contact lens which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a reflection hologram,
wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium,
wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid, and
wherein the hologram is disposed in only a part of the contact lens.
11. The device according to claim 1 , wherein the medium consists essentially of a polymer comprising the phenylboronic acid group.
12. The device according to claim 11 , wherein the medium consists of the polymer comprising the phenylboronic acid group.
13. The device according to claim 9 , wherein the medium consists essentially of a polymer comprising the phenylboronic acid group.
14. The method according to claim 10 , wherein the medium consists essentially of a polymer comprising the phenylboronic acid group.
15. The method according to claim 14 , wherein the medium consists of the polymer comprising the phenylboronic acid group.
16. The device according to claim 1 , wherein the phenylboronic acid group is selected from the group consisting of:
17. The device according to claim 1 , wherein the phenylboronic acid group is selected from the group consisting of:
18. The method according to claim 10 , wherein the phenylboronic acid group is selected from the group consisting of:
19. The method according to claim 10 , wherein the phenylboronic acid group is selected from the group consisting of: