IP Library Granted Patent US 7,639,983
Granted Patent B2
US 7,639,983 · App. 12/033,220 · Granted Dec 29, 2009

Headstage

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Quick Facts
Patent No.
US 7,639,983
App. No.
12/033,220
Granted
Dec 29, 2009
Kind
B2
Abstract

A headstage for a Neural Data Acquisition System is shown and described. In one embodiment, the headstage includes at least one Input Pre-amplifier, and a multiplexer (MUX) for multiplexing at least one channel. In one embodiment, the input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode.

Claims (45)

1. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier;

a multiplexer (MUX) for multiplexing at least one channel; and

an RF Modulator comprising a voltage control oscillator (VCO),

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode, and

wherein input impedance of the RF Modulator is configured to allow the MUX to drive the RF stare directly.

2. The headstage of claim 1 , wherein the at least one transistor is an on-chip resistor.

3. The headstage of claim 1 , wherein the at least one on-chip transistor includes at least two dual stacked transistors.

4. The headstage of claim 1 , wherein the at least one transistor includes at least one metal-oxide-semiconductor field-effect transistor (MOSFET).

5. The headstage of claim 1 , wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

6. The headstage of claim 1 , wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor.

7. The headstage of claim 1 , wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

8. The headstage of claim 1 , wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.

9. The headstage of claim 1 , further including a transmitting antenna configured to transmit at a range of about less than 10 meters, thereby permitting denser use.

10. The headstage of claim 1 , further including a power supply.

11. The headstage of claim 1 , further including a clock.

12. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier;

a multiplexer (MUX) for multiplexing at least one channel, wherein an input filter of the Input Pre-amplifier is tuned by at least one resistor; and

an RF Modulator comprising a voltage control oscillator (VCO), wherein input impedance of the RE Modulator is configured to allow the MUX to drive the RF stage directly.

13. The headstage of claim 12 , wherein the at least one resistor is a transistor configured to operate as a resistor.

14. The headstage of claim 12 , wherein the at least one resistor is an on-chip resistor.

15. The headstage of claim 14 , wherein the at least one on-chip resistor includes at least two dual stacked resistors.

16. The headstage of claim 12 , wherein the at least one resistor includes a transistor operating in sub-threshold mode.

17. The headstage of claim 12 , wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

18. The headstage of claim 12 , wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

19. The headstage of claim 12 , wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.

20. The headstage of claim 12 , wherein the MUX is configured to sample at greater than 50 kHz per channel and is configured to multiplex from a number of channels selected from at least 16 channels, at least 32 channels, at least 100 channels, and at least 250 channels.

21. The headstage of claim 12 , further including a transmitting antenna configured to transmit at a range of about less than 10 meters, thereby permitting denser use.

22. The headstage of claim 12 , further including a power supply and a clock.

23. A method of neural data monitoring, comprising the steps of:

implanting electrodes into the brain of a specimen;

connecting the electrode connector of a headstage to the implanted electrodes, wherein the headstage includes an Input Pre-amplifier, a multiplexer (MUX) for multiplexing at least one channel,

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of a transistor operating in sub-threshold mode,

wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor; and

transmitting neural data via a transmitting antenna.

24. A headstage for a neural data acquisition system, the headstage comprising:

an Input Pre-amplifier; and

a multiplexer (MUX) for multiplexing at least one channel,

wherein an input filter of the Input Pre-amplifier is tuned by adjusting the gate voltage of at least one transistor operating in sub-threshold mode,

wherein the at least one transistor includes dual stacked on-chip sub-threshold transistors, and

wherein the input bias voltage of the Pre-amplifier is tuned by the gate voltage of the dual stacked on-chip sub-threshold transistors for the at least one channel with at least one off-chip resistor.

25. The headstage of claim 24 , wherein the Input Pre-amplifier is a capacitor coupled high pass filter.

26. The headstage of claim 24 , wherein the input filter is configured to filter at a bandwidth of 0.1-10 kHz bandwidth.

27. The headstage of claim 24 , wherein the Pre-amplifier has user-selectable gain for all channels and for each channel individually.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Dec 18, 2025
From: CITIZENS BANK, N.A.
To: HARVARD BIOSCIENCE, INC.; DATA SCIENCES INTERNATIONAL, INC.
Reel/Frame 074022/0661 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Dec 29, 2020
From: CERBERUS BUSINESS FINANCE, LLC
To: HOEFER, INC.; HARVARD BIOSCIENCE, INC.; WARNER INSTRUMENTS LLC; BIOCHROM LIMITED; TRIANGLE BIOSYSTEMS, INC.; DATA SCIENCES INTERNATIONAL, INC.
Reel/Frame 054866/0502 →
SECURITY INTEREST Recorded Dec 28, 2020
From: HARVARD BIOSCIENCE, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 054855/0481 →
ASSIGNMENT FOR SECURITY -- PATENTS Recorded Feb 1, 2018
From: HOEFER, INC.; HARVARD BIOSCIENCE, INC.; WARNER INSTRUMENTS LLC; BIOCHROM LIMITED; TRIANGLE BIOSYSTEMS, INC.; DATA SCIENCES INTERNATIONAL, INC.
To: CERBERUS BUSINESS FINANCE, LLC, AS COLLATERAL AGENT
Reel/Frame 045219/0441 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jan 23, 2018
From: BANK OF AMERICA, N.A.
To: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC; TRIANGLE BIOSYSTEMS, INC.
Reel/Frame 045129/0981 →
SECURITY INTEREST Recorded Jun 9, 2017
From: HARVARD BIOSCIENCE, INC.; FKAUBI, INC.; FKA GSI US, INC.; CARTESIAN TECHNOLOGIES, INC.; GENOMIC SOLUTIONS CANADA, INC.; HOEFER, INC.; KD SCIENTIFIC, INC.; BIOCHROM US, INC.; WARNER INSTRUMENTS LLC; DENVILLE SCIENTIFIC, INC.; COULBOURN INSTRUMENTS, LLC; TRIANGLE BIOSYSTEMS, INC.
To: BANK OF AMERICA, N.A.
Reel/Frame 042753/0971 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2014
From: IRAZOQUI-PASTOR, PEDRO; MORIZIO, JAMES C.; GO, VINSON L.; PARMENTIER, JACK D.
To: TRIANGLE BIOSYSTEMS, INC.
Reel/Frame 033823/0275 →